Roswell Park Cancer Institute

This study looked at whether switching from banned e-cigarette flavors (like fruit or candy) to a tobacco flavor or using nicotine pouches could reduce signs of inflammation in daily vapers. 163 participants were randomly assigned to one of these options. The goal was to see if t…

This early-phase trial tested a light-measuring system used during photodynamic therapy (PDT) for people with malignant mesothelioma, non-small cell lung cancer, or other pleural cancers. Nine participants received the drug porfimer sodium, which becomes active when exposed to li…

This early-phase trial tested a cancer vaccine (CDX-1401) along with an immune booster, chemotherapy, and an immunotherapy drug in 8 people with myelodysplastic syndrome (MDS) or low-blast acute myeloid leukemia (AML). The goal was to see if the combination is safe and helps the …

This phase II trial tested a combination of three drugs—TAS-102, irinotecan, and bevacizumab—in 42 people with advanced colorectal cancer that had spread or couldn't be removed. The goal was to see if this mix could slow tumor growth better than standard treatments. Participants …

This early-phase trial tested a vaccine called SurVaxM in 19 people with metastatic neuroendocrine tumors. The vaccine is designed to teach the immune system to recognize and attack tumor cells that produce a protein called survivin. The main goal was to see if the vaccine is saf…

This study tested a combination of two drugs—sorafenib (a targeted therapy) and pembrolizumab (an immunotherapy)—in 37 people with advanced liver cancer that had spread. The goal was to see if the combo could shrink tumors and help people live longer. The trial was early-stage, s…

This early-phase study tested a vaccine called CIMAvax-EGF in 20 people at high risk for lung cancer or survivors at risk of recurrence. The vaccine works by helping the body make antibodies against a protein that can fuel cancer growth. Researchers checked for side effects and m…

This study tested a device called ivWatch® that monitors IV sites during chemotherapy. If the medication starts leaking out of the vein, the device alerts the nurse early, before visible signs appear. Over 2,400 cancer patients took part to see if the device could prevent tissue …

This study tests a technique called episodic future thinking (EFT) to help smokers reduce cigarette use. Participants imagine positive events they look forward to in the next year, like a vacation or family gathering, and receive smartphone prompts. The goal is to see if focusing…

This early-phase trial tested a treatment called photodynamic therapy for people with advanced lung cancer that blocks airways. Patients received a light-sensitive drug followed by a laser to activate it inside the tumor. The goal was to see if the treatment is safe and can shrin…

This phase 2 trial tested whether adding venlafaxine (an antidepressant) to a standard pain regimen of gabapentin, methadone, and oxycodone could better control pain in 62 people with head and neck cancer undergoing chemoradiation. The study measured pain scores and side effects …

This completed pilot study looked at how the drug tamoxifen affects breast cancer tumors at a molecular level. Researchers studied 59 patients with a specific type of breast cancer to see how tamoxifen changes the interaction between two key proteins. The goal was to gather infor…

This completed study looked at how nicotine salt-based vaping products compare to free-base nicotine e-liquids. Fifteen daily vapers tried different flavors and nicotine levels, and researchers measured nicotine levels in their blood and asked about harshness and satisfaction. Th…