Roswell Park Cancer Institute

This early-phase trial tested a combination of a cancer vaccine (CDX-1401), an immune booster (poly ICLC), chemotherapy (decitabine), and an immunotherapy drug (nivolumab) in 8 people with myelodysplastic syndrome (MDS) or low-blast acute myeloid leukemia (AML). The main goal was…

This study tested a combination of three drugs (TAS-102, irinotecan, and bevacizumab) in 42 people with advanced colorectal cancer that had already been treated and spread or couldn't be removed. The goal was to see if this mix could slow cancer growth better than standard treatm…

This early-phase study tested a vaccine called SurVaxM in 19 people with neuroendocrine tumors that had spread. The vaccine teaches the immune system to recognize and attack tumor cells. The main goals were to check safety and see if the vaccine triggers an immune response.

This early-phase study tested a system that measures how much laser light reaches tumors during photodynamic therapy (PDT) in people with mesothelioma, non-small cell lung cancer, or other cancers that spread to the lining of the lungs. Nine participants received a light-activate…

This study tested a combination of two drugs, sorafenib and pembrolizumab, in 37 adults with advanced liver cancer that had spread. The goal was to see if the combination could shrink tumors and help patients live longer. The approach uses one drug to block cancer cell growth and…

This study tested a device called ivWatch that monitors IV sites in cancer patients getting chemotherapy. The goal was to see if it could detect when medication leaks out of the vein into surrounding tissue before a nurse notices. Over 2,400 patients took part, and the device may…

This early-phase trial tested a vaccine called CIMAvax-EGF in 20 people at high risk for lung cancer or survivors at risk of recurrence. The vaccine works by helping the body make antibodies against a protein (EGF) that can fuel cancer growth. Researchers measured immune response…

This study looked at whether adding venlafaxine (a medicine often used for depression) to standard painkillers like gabapentin, methadone, and oxycodone can better manage pain in people with head and neck cancer who are getting chemotherapy and radiation. About 62 adults with sta…

This study looked at how nicotine salt-based vaping products compare to free-base nicotine e-liquids. Fifteen daily vapers had their blood nicotine levels measured and reported how harsh or satisfying each product felt. The goal was to understand the abuse potential of different …

This study looked at how the breast cancer drug tamoxifen interacts with certain proteins inside tumor cells. Researchers studied 59 women with a common type of breast cancer to better understand why some tumors respond to tamoxifen and others do not. The goal is to use this know…