Experimental combo vaccine and drugs show promise for blood cancers

NCT ID NCT03358719

First seen Mar 13, 2026 · Last updated May 15, 2026 · Updated 8 times

Summary

This early-phase trial tested a combination of a cancer vaccine (CDX-1401), an immune booster (poly ICLC), chemotherapy (decitabine), and an immunotherapy drug (nivolumab) in 8 people with myelodysplastic syndrome (MDS) or low-blast acute myeloid leukemia (AML). The main goal was to check safety and side effects. Researchers also looked at how the treatment affected the immune system and cancer cells. The study is complete, but results are not yet widely reported.

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Contacts and locations

Locations

  • Roswell Park Cancer Institute

    Buffalo, New York, 14263, United States

Conditions

Explore the condition pages connected to this study.