Roswell Park Cancer Institute

This study tests a vaccine called SurVaxM, given with standard chemotherapy, for people with a newly diagnosed aggressive brain cancer (glioblastoma). The vaccine is designed to train the immune system to attack cancer cells. The main goal is to see if adding the vaccine helps ke…

This study tested two drugs, pazopanib and bevacizumab, given in turns to people with advanced kidney cancer that had spread. The goal was to find the best dose and see if the combination helps control the disease. 51 patients took part, and the study looked at side effects and h…

This study was designed to test the safety and best dose of an experimental oral drug called GB1211 (Selvigaltin) when added to standard chemotherapy for people with multiple myeloma that has come back or stopped responding. The drug works by blocking a protein linked to inflamma…

This early-stage study tests whether a vaccine made from a protein called survivin can safely help the immune system fight multiple myeloma. About 18 adults whose myeloma has partially responded to initial treatment will receive the vaccine along with standard lenalidomide mainte…

This study tests how well a brain stimulation technique called rTMS helps people stop smoking and avoid starting again. Researchers are looking for the best dose by studying 206 smokers who want to quit. Participants receive rTMS, which uses magnetic pulses to boost brain activit…

This very early study tests a vaccine (CIMAvax-EGF) given with standard treatments for metastatic colorectal cancer that has certain gene types. The goal is to see if the vaccine can trigger the immune system to fight the cancer. Only 2 people are enrolled, so results are very li…

This early-stage trial tests a new treatment for ovarian, fallopian tube, or peritoneal cancer that has returned or not responded to standard therapy. Patients receive their own immune cells (T cells) that have been genetically modified to recognize and attack cancer cells, along…

This study tests a chemotherapy drug called CPX-351 in people under 60 who have a type of leukemia that developed from a previous blood disorder or cancer treatment. The goal is to see how well the drug can stop the cancer from growing and achieve remission. About 21 participants…

This study tests whether a combination of three drugs (enteric-coated aspirin, rintatolimod, and interferon-alpha 2b) can boost the immune system's ability to fight prostate cancer when given before surgery. About 12 men with early-stage prostate cancer who are scheduled for pros…

This early-phase study tests a new treatment for adults with advanced liver cancer that has not responded to at least two standard therapies. The treatment uses the patient's own immune cells, which are modified in a lab to recognize and attack cancer cells that have a specific p…

This study tests whether a single, powerful dose of targeted radiation (SBRT) can be as safe and effective as multiple doses for people with central non-small cell lung cancer. About 30 participants with early-stage tumors will receive one treatment and be monitored for side effe…

This study tests a combination of the CIMAvax vaccine (which targets a protein that helps tumors grow) and nivolumab (an immunotherapy that boosts the immune system) in people with advanced non-small cell lung cancer or squamous head and neck cancer. The goal is to find the best …

This program offers SurVaxM, an experimental vaccine, to glioblastoma patients who have no other treatment options or who previously benefited from it in a trial. Early data suggest SurVaxM may help extend survival when used alone or with chemotherapy. The goal is to control the …

This study tests whether a combination of belantamab mafodotin (a targeted antibody-drug) and lenalidomide can eliminate leftover cancer cells in multiple myeloma patients who still have detectable disease after a stem cell transplant. The trial enrolls adults aged 18 and older w…

This study tests whether adding a drug called cyclophosphamide after a stem cell transplant can lower the risk of graft-versus-host disease (GVHD), a serious complication where donor cells attack the patient's body. The trial includes 35 adults with various blood cancers or sever…

This early-phase study tested a new combination of drugs (carfilzomib plus standard chemotherapy) in 29 adults with diffuse large B-cell lymphoma that had come back or not responded to prior treatment. The main goals were to find the safest dose of carfilzomib and see how well th…

This study tests a culturally-appropriate education program called Indigenous SIPin for Native American men who are part of athletic communities. The goal is to help them drink fewer sugary beverages like soda and juice, which can lead to obesity, diabetes, heart disease, and som…

This study tests a program called PC TEACH that helps rural doctor's offices improve how they offer the HPV vaccine to teens. The goal is to increase vaccination rates and prevent HPV-related cancers. About 203 clinics and staff are taking part. Researchers hope this approach can…

This study tests whether using a machine learning program to closely monitor symptoms can help head and neck cancer patients avoid urgent hospital visits during radiation therapy. About 72 adults with non-spreading head and neck cancer will either receive standard care or extra s…

This early-stage trial looks at whether giving one very precise, high-dose radiation treatment after lung cancer surgery is safe and causes fewer side effects than the usual weeks of daily radiation. About 50 adults with non-small cell lung cancer who had surgery but still have s…

This study tests a technique called episodic future thinking (EFT) to help smokers reduce cigarette use. Participants imagine positive events they look forward to in the next year, while a control group recalls positive past events. The goal is to see if focusing on the future lo…

This study looks at whether delivering fresh produce, with or without nutrition education, can improve diet and food security in low-income families in Western New York. About 50 adults who are the main food shoppers in their households will take part. The goal is to see if this …