Roswell Park Cancer Institute

This early-phase trial tests whether a vaccine made from a protein called survivin can safely boost the immune system to fight multiple myeloma. The study involves 18 patients who have already responded to initial treatment and are taking lenalidomide as maintenance therapy. The …

This early-phase trial tests a new treatment called RPCAR01 for people with advanced liver cancer that has not responded to standard therapies. The treatment uses a patient's own immune cells, modified in a lab to better recognize and attack cancer cells that carry a protein call…

This phase 2 trial tests whether giving a combination of enteric-coated aspirin, rintatolimod, and interferon-alpha 2b before prostate cancer surgery can boost the immune system's attack on tumors. The study involves 12 men with localized prostate cancer who are scheduled for sur…

This study tests whether giving the immunotherapy drug pembrolizumab every 12 weeks works as well as the standard every 3 weeks in people with non-small cell lung cancer who are already benefiting from the drug. The goal is to see if fewer treatments can keep the cancer under con…

This early-stage trial aimed to test the safety and best dose of an experimental oral drug called selvigaltin when added to standard treatments for multiple myeloma that had come back or stopped responding. The study was withdrawn before enrolling any participants, so no results …

This study tests whether a single, powerful dose of targeted radiation (SBRT) can safely control central non-small cell lung cancer, instead of the usual multiple sessions. About 30 adults with early-stage tumors near the chest center will receive one treatment. Researchers will …

This study tests a stem cell transplant method for people with blood cancers like leukemia or lymphoma. The approach uses chemotherapy, total body radiation, and a drug called cyclophosphamide after the transplant to prevent graft-versus-host disease, where donor cells attack the…

This early-phase trial tests a new approach for people with ovarian, fallopian tube, or peritoneal cancer that has returned or not responded to standard treatments. Patients receive their own T cells, which are genetically modified to recognize and attack cancer cells, along with…

This phase 2 trial tests whether combining belantamab mafodotin (a targeted antibody-drug conjugate) with lenalidomide can eliminate minimal residual disease in multiple myeloma patients who still have detectable cancer after a stem cell transplant. The study enrolls 4 adults who…

This phase II study tests a vaccine called SurVaxM, designed to train the immune system to attack glioblastoma cells, when given alongside standard chemotherapy (temozolomide). The trial includes 66 patients with newly diagnosed, survivin-positive glioblastoma or gliosarcoma. The…

This early-phase trial tests whether adding the CIMAvax-EGF vaccine to standard chemotherapy and targeted drugs can trigger an immune response against metastatic colorectal cancer. Only 2 participants with a specific gene type (RAS/BRAF wild-type) were enrolled. The main goal is …

This study tests two drugs, pazopanib and bevacizumab, given one after the other in people with advanced kidney cancer that has spread. The goal is to find the best dose and see how well the combination works. About 51 patients who have not had prior treatment will take part. The…

This study tests repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation technique, to help current smokers quit and avoid relapse. Researchers are enrolling 206 right-handed smokers who smoke 5-25 cigarettes daily and want to quit within 30 days. Th…

This early-phase trial tested adding carfilzomib to a standard chemotherapy regimen (R-ICE) for adults with diffuse large B-cell lymphoma that returned or didn't respond to prior treatment. The main goals were to find the safest dose of carfilzomib and see how well the combinatio…

This study tests a culturally appropriate education program called Indigenous SIPin to help Native American men reduce their intake of sugary drinks like soda and juice. The program includes classes and text messages, and involves 48 men from Native American athletic communities.…

This study tests a chemotherapy drug called CPX-351 in people under 60 with secondary acute myeloid leukemia (AML), a type of leukemia that develops after other blood disorders or cancer treatments. The goal is to see how well the drug can make the cancer disappear or improve blo…

This study combines the CIMAvax EGF vaccine with immunotherapy drugs (nivolumab or pembrolizumab) to treat advanced non-small cell lung cancer and squamous head and neck cancer. The vaccine aims to slow tumor growth, while the immunotherapy helps the immune system attack cancer c…

This program gives certain glioblastoma patients access to SurVaxM, a drug that helps the immune system fight brain cancer. It is for patients who cannot join other trials or who have already benefited from SurVaxM in a previous study. The treatment involves four doses given two …

This study looks at ways to help more teens in rural areas get the HPV vaccine, which can prevent certain cancers. Researchers are working with 203 primary care practices to test a program called PC TEACH. The goal is to make it easier for families to get the vaccine on time.

This early-stage study tests whether giving a single, very focused dose of radiation after lung cancer surgery is safe and causes fewer side effects than standard weeks-long radiation. It involves 50 adults with non-small cell lung cancer who had surgery but still have cancer cel…

This study tests whether using machine learning to closely monitor symptoms can help head and neck cancer patients avoid urgent hospital visits during radiation therapy. Researchers will compare intensive symptom tracking plus standard care to standard care alone in 72 patients w…

This study looks at whether delivering half-price produce boxes, with or without nutrition education, can help low-income families eat better and feel more food secure. Researchers will enroll 50 adults in Western New York who struggle to afford healthy food. The goal is to see i…