New drug combo aims to tame stem cell Transplant's worst side effect

NCT ID NCT03192397

First seen Apr 20, 2026 · Last updated Jun 07, 2026 · Updated 10 times

Summary

This study tests whether adding a drug called cyclophosphamide after a stem cell transplant can reduce the risk of graft-versus-host disease (GVHD), a serious complication where donor cells attack the patient's body. The trial includes 35 adults with various blood cancers or severe aplastic anemia who are getting a transplant from a matched donor. Participants receive chemotherapy and radiation before the transplant, then cyclophosphamide afterward to help prevent GVHD.

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Contacts and locations

Locations

  • Roswell Park Cancer Institute

    Buffalo, New York, 14263, United States

Conditions

Explore the condition pages connected to this study.