GRAFT VERSUS HOST DISEASE

This study tests whether adding the drug belumosudil to standard care can better prevent graft-versus-host disease (GVHD) in adults with blood cancer who have had a stem cell transplant. About 46 participants will receive belumosudil alongside their usual GVHD prevention medicine…

This early-phase trial tests whether adding emapalumab to standard medications can safely prevent graft-versus-host disease (GVHD) in 15 adults with acute myeloid leukemia or myelodysplastic syndrome receiving a reduced-intensity donor stem cell transplant. Emapalumab blocks an i…

This study tests a device that removes specific immune cells from donated stem cells before transplant. The goal is to lower the risk of graft-versus-host disease, a serious complication where donor cells attack the patient's body. The study includes up to 90 children and young a…

This study tests whether a cord blood transplant, used as a first or second transplant, can help children and young adults (up to age 26) with blood cancers like leukemia and lymphoma. About 71 participants will receive the transplant to see if it keeps them cancer-free for at le…

This early-phase study tests whether adding two natural proteins (uhCG/EGF) to standard post-transplant chemotherapy can safely prevent graft-versus-host disease (GVHD) in patients receiving stem cells from partially matched donors. About 18 adults with blood cancers who lack a f…

This early-phase study tests whether two drugs, ruxolitinib and abatacept, can prevent graft-versus-host disease (GVHD) and cytokine release syndrome in 41 blood cancer patients receiving a half-matched stem cell transplant. The goal is to reduce dangerous immune reactions while …

This study tests a new drug, rovadicitinib, for people with moderate to severe chronic graft-versus-host disease (cGVHD) after a stem cell transplant. Participants have already tried 2 to 5 other treatments. The goal is to see if rovadicitinib improves symptoms better than standa…

This study tests two different chemotherapy conditioning plans combined with a single drug (cyclophosphamide and methotrexate) to prevent graft-versus-host disease (GVHD) after a stem cell transplant. About 82 adults with blood cancer who have a matched donor will participate. Th…

This study compares a reduced dose (35mg/kg) versus the standard dose (50mg/kg) of a drug called cyclophosphamide, given after a stem cell transplant to prevent graft-versus-host disease (GVHD). About 316 people receiving a transplant from a matched unrelated or half-matched dono…

This study tests whether the drug ruxolitinib, taken as a maintenance therapy after a stem cell transplant, can help prevent T-cell lymphoma from coming back and reduce the risk of graft-versus-host disease (GVHD), a common complication where donor cells attack the patient's body…

This study tests a new drug called BPC2001 to prevent acute graft-versus-host disease (aGVHD) in people receiving a stem cell transplant from a half-matched donor. aGVHD is a serious condition where donor immune cells attack the patient's body. The trial includes 50 adults with b…

This early-stage trial tests whether injecting special bone marrow cells (called mesenchymal stromal cells) into the salivary glands is safe and can help relieve dry mouth. The study includes 36 adults with dry mouth not caused by radiation, such as from Sjogren's disease or graf…

This study tests a group-based telehealth program called HORIZONS for adults with chronic graft-versus-host disease (cGVHD) after a bone marrow transplant. The goal is to see if the program improves quality of life and self-management compared to usual care. About 350 participant…

This study tests whether shining a special light inside the mouth (photobiomodulation) can safely relieve painful sores caused by chronic graft-versus-host disease (GVHD) after a stem cell transplant. About 44 people aged 4 and older who have not improved with standard treatments…

This study tests whether moxibustion, a traditional Chinese medicine technique that burns herbs near the skin, can help people with severe graft-versus-host disease (GVHD) after a stem cell transplant. About 42 patients who have not responded to steroids will receive standard sec…

This study looks at whether a special lung scan (called PRM) can help detect chronic lung injury in people who have had a blood stem cell transplant. Researchers will follow 375 patients for one year to see if the scan can predict who will develop lung problems or get worse. The …

This study follows people who have had or will soon have a stem cell transplant from a donor. It aims to understand how chronic graft-versus-host disease (cGVHD) affects the mouth. Researchers will collect saliva, mouth swabs, and photos over three years. Healthy volunteers are a…

This study collects blood stem cells from 500 healthy volunteers to develop better ways to process them for transplants. The goal is to remove the white blood cells that can cause a serious complication called graft-versus-host disease while keeping the stem cells needed for reco…

This study looks at how the body breaks down certain carbohydrates (FODMAPs) in the gut and whether that affects graft-versus-host disease (GVHD) after a bone marrow transplant. Researchers will follow 100 transplant patients to track when and how severe GVHD occurs. The goal is …