GRAFT VERSUS HOST DISEASE
Clinical trials for GRAFT VERSUS HOST DISEASE explained in plain language.
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New drug shows promise in preventing Graft-Versus-Host disease
Disease control CompletedThis early study tested the drug belimumab (Benlysta) to see if it could prevent chronic graft-versus-host disease (GvHD) in 10 adults who had a stem cell transplant for blood cancer. GvHD is a serious condition where the donor's immune cells attack the patient's body. The main g…
Matched conditions: GRAFT VERSUS HOST DISEASE
Phase: PHASE1 • Sponsor: Washington University School of Medicine • Aim: Disease control
Last updated Jun 27, 2026 12:10 UTC
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New drug combo shows promise in preventing transplant complications
Disease control CompletedThis early-stage study tested whether adding a drug called BMS-986004 to standard immune-suppressing medicine could help prevent acute graft-versus-host disease (GVHD) in 45 adults with blood cancers or disorders receiving a stem cell transplant. GVHD occurs when donor immune cel…
Matched conditions: GRAFT VERSUS HOST DISEASE
Phase: PHASE1 • Sponsor: H. Lee Moffitt Cancer Center and Research Institute • Aim: Disease control
Last updated Jun 27, 2026 12:04 UTC
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Lower chemo dose may prevent transplant complications
Disease control CompletedThis study tested whether a low dose of the drug cyclophosphamide, given after a stem cell transplant, can prevent graft-versus-host disease (GVHD) — a common and serious complication where donor cells attack the patient's body. The trial involved 35 adults with various blood dis…
Matched conditions: GRAFT VERSUS HOST DISEASE
Phase: PHASE2 • Sponsor: Hospital Universitario Dr. Jose E. Gonzalez • Aim: Disease control
Last updated Jun 27, 2026 08:08 UTC
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New hope for GVHD patients: nilotinib steps in when imatinib fails
Disease control CompletedThis study tested the drug nilotinib in 65 adults with chronic graft-versus-host disease (GVHD) who did not respond to imatinib. GVHD is a complication after a stem cell transplant where donor cells attack the patient's body. The goal was to see if nilotinib could help control th…
Matched conditions: GRAFT VERSUS HOST DISEASE
Phase: PHASE2 • Sponsor: University Hospital, Lille • Aim: Disease control
Last updated Jun 27, 2026 08:06 UTC
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Stem cell infusion shows promise for Hard-to-Treat GVHD
Disease control CompletedThis phase 2 study tested a stem cell product called Prochymal in 11 patients with severe graft-versus-host disease (GVHD) that did not improve with standard treatments. The goal was to see if the infusion could reduce or resolve GVHD symptoms by day 28. The study measured comple…
Matched conditions: GRAFT VERSUS HOST DISEASE
Phase: PHASE2 • Sponsor: Mesoblast, Inc. • Aim: Disease control
Last updated Jun 27, 2026 07:56 UTC
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New hope for tough GvHD: pomalidomide shows promise in small trial
Disease control CompletedThis study tested a drug called pomalidomide in 34 adults with chronic graft-versus-host disease (GvHD) that didn't improve with standard treatments. GvHD can happen after a stem cell transplant when the donor cells attack the recipient's body. Participants took pomalidomide caps…
Matched conditions: GRAFT VERSUS HOST DISEASE
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 27, 2026 07:53 UTC
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Blood 'bath' with light may stop transplant complication
Disease control CompletedThis study tested whether a procedure called extracorporeal photophoresis (ECP) could prevent graft-versus-host disease (GVHD) in 158 people receiving stem cell transplants for blood cancers. ECP involves removing white blood cells, treating them with a light-sensitive drug and U…
Matched conditions: GRAFT VERSUS HOST DISEASE
Phase: NA • Sponsor: Oslo University Hospital • Aim: Disease control
Last updated Jun 27, 2026 07:51 UTC
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New PET tracer aims to catch a dangerous transplant complication early
Diagnosis CompletedThis small Phase 1 study tested whether a radioactive tracer called [18F]F-AraG can help detect graft-versus-host disease (GVHD) using PET scans. GVHD is a serious condition where donor immune cells attack the recipient's body after a stem cell transplant. The study involved 9 pa…
Matched conditions: GRAFT VERSUS HOST DISEASE
Phase: PHASE1 • Sponsor: CellSight Technologies, Inc. • Aim: Diagnosis
Last updated Jun 27, 2026 08:03 UTC
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New eye drops aim to soothe dry eye in bone marrow transplant patients
Symptom relief CompletedThis study tested whether CAM-101 eye drops are safe and can help relieve dry eye in people who developed the condition after a bone marrow transplant (graft-versus-host disease). 64 adults received either a low or high dose of CAM-101 or a placebo drop four times a day for six w…
Matched conditions: GRAFT VERSUS HOST DISEASE
Phase: PHASE1, PHASE2 • Sponsor: Cambium Bio Limited • Aim: Symptom relief
Last updated Jun 27, 2026 13:06 UTC
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Scientists track mouth health to unlock secrets of transplant complication
Knowledge-focused CompletedThis study followed 190 adults who had or were about to have a stem cell transplant from a donor. Researchers tracked changes in the mouth, like dryness or sores, to learn more about chronic graft-versus-host disease (cGVHD). Participants provided saliva, mouth swabs, and had den…
Matched conditions: GRAFT VERSUS HOST DISEASE
Sponsor: National Institute of Dental and Craniofacial Research (NIDCR) • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:04 UTC