Personalized vaccine plus chemo cocktail aims to outsmart advanced ovarian cancer
NCT ID NCT02432378
First seen Jul 08, 2026 · Last updated Jul 09, 2026 · Updated 1 time
Summary
This trial tests whether adding a personalized vaccine and immune-boosting drugs to standard chemotherapy can help the body fight advanced ovarian cancer more effectively. Participants receive chemotherapy directly into the abdomen along with oral medication and injections of a vaccine made from their own immune cells. The study measures changes in immune cell activity and tumor response.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Cisplatin, celecoxib, interferon-alpha, rintatolimod, and autologous alpha-DC1 vaccine
- What this could lead to
- If successful, this approach could improve immune response and increase the chance of complete tumor clearance in advanced ovarian cancer.
- What could go wrong
- This is an early-phase trial with a small number of participants, so results may not apply broadly. The combination therapy may cause significant side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Hillman Cancer Center
Pittsburgh, Pennsylvania, 15232, United States
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UPMC CancerCenter at Magee-Womens Hospital of UPMC
Pittsburgh, Pennsylvania, 15213, United States
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