Could testosterone therapy be safe for men with prostate cancer? new trial aims to find out

NCT ID NCT06733350

Recruiting now Disease control Sponsor: Roswell Park Cancer Institute Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether testosterone replacement therapy (TRT) is safe and beneficial for men with low testosterone and early-stage prostate cancer who are on active surveillance. Researchers will track cancer progression, quality of life, and whether men stay on active surveillance. The trial aims to address concerns that TRT might fuel cancer growth.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: testosterone replacement therapy
What this could lead to: If it works, this could show that testosterone therapy is safe for men with low testosterone and early prostate cancer, improving their quality of life without raising cancer risk.
What could go wrong: This is a phase 4 trial, but results may not apply to all patients. There is a long-standing concern that testosterone could make prostate cancer grow, so safety is still being tested.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

prostate cancer prostate carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LOCALIZED PROSTATE CARCINOMA STAGE I PROSTATE CANCER AJCC V8 STAGE II PROSTATE CANCER AJCC V8 STAGE III PROSTATE CANCER AJCC V8

Contacts and locations

Locations

Roswell Park Cancer Institute
RECRUITING

Buffalo, New York, 14263, United States

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