Freezing or heating prostate tumors: a targeted alternative to surgery?

NCT ID NCT06178354

Recruiting now Disease control Sponsor: University of California, Davis Source: ClinicalTrials.gov ↗

First seen Jun 30, 2026 · Last updated Jul 01, 2026 · Updated 1 time

Summary

This trial tests whether focal ablation—using extreme cold (cryotherapy) or high-intensity ultrasound (HIFU)—can effectively destroy prostate tumors while leaving healthy tissue unharmed. It enrolls men with early-stage, localized prostate cancer that shows up on MRI. The goal is to control the disease with fewer side effects than whole-gland treatments like surgery or radiation.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: focal cryotherapy or high-intensity focused ultrasound
What this could lead to: If successful, this approach could offer a less invasive treatment option for localized prostate cancer, potentially reducing side effects like incontinence and impotence compared to whole-gland treatments.
What could go wrong: This is a phase 2 study with only 100 participants, so results are preliminary. The cancer may not be fully controlled, and some men may still need additional treatment. Risks include infection, bleeding, and urinary or sexual problems.

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Conditions

The condition(s) this trial relates to.

prostate cancer prostate carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LOCALIZED PROSTATE CARCINOMA STAGE I PROSTATE CANCER AJCC V8 STAGE II PROSTATE CANCER AJCC V8 STAGE IIIA PROSTATE CANCER AJCC V8 STAGE IIIB PROSTATE CANCER AJCC V8

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

University of California Davis Comprehensive Cancer Center
RECRUITING

Sacramento, California, 95817, United States

Contact Email: •••••@•••••

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