LOCALIZED PROSTATE CARCINOMA

This trial tests whether focal ablation—using extreme cold (cryotherapy) or high-intensity ultrasound (HIFU)—can effectively destroy prostate tumors while leaving healthy tissue unharmed. It enrolls men with early-stage, localized prostate cancer that shows up on MRI. The goal is…

This study tests a new way to deliver radiation therapy for early-stage prostate cancer. Instead of two separate sessions days apart, both radiation doses are given just three hours apart on the same day. The goal is to see if this is safe and could make treatment more convenient…

This study tests whether testosterone replacement therapy (TRT) is safe and beneficial for men with low testosterone and early-stage prostate cancer who are on active surveillance. Researchers will track cancer progression, quality of life, and whether men stay on active surveill…

This study tests two types of targeted radiation therapy (177Lu-PSMA-617 and 225Ac-PSMA-617) in 45 men with high-risk prostate cancer who are scheduled for prostate removal surgery. The goal is to see which therapy delivers more radiation to the tumor and how it affects the immun…

This study is testing a new type of radiation therapy that adapts to changes in the prostate and bladder during each treatment session. It is for men with localized prostate cancer who also have an enlarged prostate or urinary symptoms. The goal is to see if this approach can red…

This trial tests whether wrapping the nerves around the prostate with a special tissue allograft during surgery can reduce erectile dysfunction and incontinence. 25 men with localized prostate cancer will receive the wrap during nerve-sparing prostate removal. The study focuses o…

This study tests whether a very short course of radiation (5 days) is as safe and effective as a longer course (2-3 weeks) for men with localized prostate cancer. All participants also receive a brachytherapy boost. The main goal is to compare side effects and quality of life ove…

This study compares a newer PSMA PET scan to the standard MRI for staging prostate cancer in men eligible for focal therapy (treatment that targets only the tumor). About 138 men with early-stage prostate cancer will be randomly assigned to get the PSMA PET scan or not. The goal …

This early-phase trial is testing whether a special MRI scan, using hyperpolarized pyruvate and urea, can better detect high-grade prostate cancer that is still confined to the prostate. About 80 men scheduled for prostate removal will receive an IV of these substances before ima…

This study tests whether a combined PET/MRI scan using a radioactive tracer can accurately detect if prostate cancer has spread to nearby lymph nodes. Fifty men with high-risk localized prostate cancer will receive the scan before their planned prostate removal surgery. The resul…

This study tests whether a supervised golf exercise program can improve physical function, mental health, and quality of life in prostate cancer survivors who are on hormone therapy. Twenty men aged 55-85 with little or no golf experience will participate. The program includes wa…

This study is looking at how common low vitamin D levels are among Black men with prostate cancer, and whether vitamin D supplements can improve their immune function. Researchers will measure vitamin D and immune markers in blood samples before and after supplementation. The goa…

This study looks at how well a short course of hormone therapy (ADT) works in men with high-risk prostate cancer that hasn't spread. Researchers use a special PET/CT scan to measure changes in cancer activity before and after treatment. About 50 men will take part, and they will …

This study looks at how a type of radiation called HDR brachytherapy changes prostate cancer on a molecular level. Researchers will analyze blood, tissue, and gut bacteria samples from 100 men with low-risk or early intermediate-risk prostate cancer. The goal is to find the best …

This study compares a standard survivorship care plan to one tailored for low health literacy in 150 African American men who have finished treatment for localized or limited-spread prostate cancer. The goal is to see if the tailored plan helps them better understand their follow…