LOCALIZED PROSTATE CARCINOMA

This study looks at whether testosterone replacement therapy (TRT) is safe and beneficial for men with low-risk prostate cancer who are on active surveillance (watchful waiting). Many men with low testosterone avoid TRT due to fears it might worsen their cancer, but this trial ai…

This study is for men with high-risk prostate cancer that hasn't spread. It tests how well a short course of hormone therapy (ADT) shrinks the cancer before surgery. Researchers use a special PET scan (PSMA PET/CT) to measure changes in the cancer. The goal is to see if this appr…

This early-stage study tests two types of targeted radiation therapy (177Lu-PSMA-617 and 225Ac-PSMA-617) in 45 men with high-risk prostate cancer who are scheduled for prostate removal surgery. The goal is to see which therapy delivers more radiation to the tumor and how it affec…

This study tests a precise type of radiation therapy (SBRT) that adapts to changes in the prostate each week for men with localized prostate cancer who also have urinary symptoms or an enlarged prostate. The goal is to see if this approach reduces side effects while effectively c…

This study is testing a special MRI technique that uses a substance called hyperpolarized pyruvate to help doctors find aggressive prostate cancer. The goal is to see if this scan can tell the difference between high-grade and low-grade cancer, as well as normal tissue. About 80 …

This study tests whether a new type of PET/MRI scan can accurately detect if prostate cancer has spread to nearby lymph nodes. About 50 men with high-risk prostate cancer who are scheduled for prostate removal surgery will receive this scan beforehand. The goal is to see if the s…

This study compares two types of radiation therapy for localized prostate cancer: a newer ultra-short course versus a standard shorter course, both combined with a precise internal radiation boost. Researchers want to see if the ultra-short approach causes fewer urinary and bowel…

This study tests whether a supervised golf exercise program can improve physical function, mental health, and quality of life in prostate cancer survivors who are on hormone therapy. Twenty men aged 55-85 with little or no golf experience will participate. The program includes wa…

This study tests a special tissue wrap placed on the nerves during prostate removal surgery for men with localized prostate cancer. The wrap aims to reduce common side effects like erectile dysfunction and urine leakage. About 25 men will take part to see if the wrap is safe and …

This study looks at how common low vitamin D levels are in African American men with prostate cancer, and whether correcting those levels can improve immune function. Researchers will measure vitamin D and immune cells in blood samples before and after supplementation. The goal i…

This study is for men with early-stage prostate cancer who are getting a type of radiation called HDR brachytherapy. Researchers will use advanced lab tests to see how the radiation changes the tumor's chemistry and immune response. The goal is to find the best radiation dose wit…

This study compares a standard survivorship care plan to one that is tailored for people with lower health literacy. The goal is to see if the tailored plan helps African American prostate cancer patients better understand their treatment side effects and follow-up care. About 15…