New scan may spare prostate cancer patients unnecessary surgery

NCT ID NCT06389786

Recruiting now Diagnosis Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a combined PET/MRI scan using a radioactive tracer can accurately detect if prostate cancer has spread to nearby lymph nodes. Fifty men with high-risk localized prostate cancer will receive the scan before their planned prostate removal surgery. The results will be compared to the actual findings from lymph node tissue removed during surgery to see how well the scan predicts spread.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: 18F-rhPSMA-7.3 (a radioactive tracer for PET imaging)
What this could lead to: If successful, this imaging method could help doctors decide which patients need lymph node removal during prostate cancer surgery, avoiding unnecessary procedures.
What could go wrong: This is a small, early-stage study (50 participants) focused on accuracy, not treatment. The scan may not be accurate enough to replace standard surgery in all cases.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

metastatic prostate carcinoma prostate cancer prostate carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LOCALIZED PROSTATE CARCINOMA OLIGOMETASTATIC PROSTATE CARCINOMA STAGE I PROSTATE CANCER AJCC V8 STAGE II PROSTATE CANCER AJCC V8 STAGE III PROSTATE CANCER AJCC V8 STAGE IVA PROSTATE CANCER AJCC V8

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Mayo Clinic in Florida
RECRUITING

Jacksonville, Florida, 32224-9980, United States

Contact Email: •••••@•••••

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