Walking away from prostate cancer: 36 men test exercise as therapy

NCT ID NCT05751434

Ongoing Disease control Sponsor: City of Hope Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 trial tests whether a personalized walking program can slow the progression of localized prostate cancer in men who are on active surveillance (monitoring instead of immediate treatment). The 36 participants will exercise up to 5 times per week for 225-300 minutes total, until their next routine biopsy (about 6-12 months later). Researchers will compare changes in tumor markers between the exercise group and a usual-care group to see if exercise makes the cancer less aggressive.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: exercise therapy
What this could lead to: If it works, this could show that a structured walking program helps keep localized prostate cancer from becoming more aggressive, potentially offering a non-drug way to manage the disease.
What could go wrong: This is a small, early-phase trial with only 36 men, so results may not apply to everyone. Exercise may not change cancer markers, and the study does not test long-term outcomes like preventing spread.

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Conditions

The condition(s) this trial relates to.

prostate adenocarcinoma prostate cancer prostate carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LOCALIZED PROSTATE CARCINOMA PROSTATE ADENOCARCINOMA PROSTATE CANCER

Contacts and locations

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Locations

City of Hope Medical Center

Duarte, California, 91010, United States
Hartford Healthcare Alliance (Data collection only)

Hartford, Connecticut, 06102, United States
Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Bergen (Limited protocol activities)

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center (All Protocol Activities)

New York, New York, 10065, United States
Memorial Sloan Kettering Monmouth (Limited protocol activities)

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau (Limited protocol activites)

Rockville Centre, New York, 11553, United States
Memorial Sloan Kettering Suffolk - Commack (Limited protocol activities)

Commack, New York, 11725, United States
Memorial Sloan Kettering Westchester (Limited protocol activities)

Harrison, New York, 10604, United States
University of California, Los Angeles (Data and Specimen Analysis Only)

Los Angeles, California, 90095-1781, United States

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