New hope for STK11 lung cancer: experimental combo enters trial
NCT ID NCT07017829
First seen Jun 24, 2026 · Last updated Jul 30, 2026 · Updated 4 times
Summary
This phase II trial tests whether adding an experimental antibody called GT103 to the immunotherapy drug pembrolizumab can help people with advanced STK11-mutant non-small cell lung cancer. The study enrolls 28 adults whose cancer has worsened despite prior pembrolizumab treatment. Participants receive both drugs intravenously, and researchers track how long the cancer stays under control and whether tumors shrink.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- GT103 (a monoclonal antibody) and pembrolizumab (an immunotherapy drug)
- What this could lead to
- If it works, this could offer a new treatment option for people with a hard-to-treat form of lung cancer that has stopped responding to standard immunotherapy.
- What could go wrong
- This is a small, early-phase trial with only 28 participants, so results may not apply to everyone. The combination could cause side effects like immune-related inflammation, and it may not improve survival.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Roswell Park Cancer Institute
RECRUITINGBuffalo, New York, 14263, United States
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