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Could a muscle relaxant help fight lung cancer? scientists test papaverine with standard therapy

NCT ID NCT05136846

Recruiting now Disease control Sponsor: Ohio State University Comprehensive Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 30, 2026 · Last updated Jul 01, 2026 · Updated 1 time

Summary

This trial investigates whether adding papaverine—a drug traditionally used as a muscle relaxant—to standard chemoradiation can improve treatment for people with stage II to III non-small cell lung cancer. Papaverine targets the energy factories inside cancer cells (mitochondria) to slow their growth. The study aims to find the safest dose and check for early signs of tumor control.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
papaverine
What this could lead to
If it works, this could point toward a new way to treat lung cancer by targeting cancer cell energy production.
What could go wrong
This is an early phase 1 trial with only 28 participants, so it is primarily testing safety and dosing. The combination may not improve outcomes or could cause unexpected side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

lung cancer lung neoplasm non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LOCALLY ADVANCED LUNG NON-SMALL CELL CARCINOMA STAGE II LUNG CANCER AJCC V8 STAGE IIA LUNG CANCER AJCC V8 STAGE IIB LUNG CANCER AJCC V8 STAGE III LUNG CANCER AJCC V8 STAGE IIIA LUNG CANCER AJCC V8 STAGE IIIB LUNG CANCER AJCC V8 STAGE IIIC LUNG CANCER AJCC V8 UNRESECTABLE LUNG NON-SMALL CELL CARCINOMA

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • City of Hope

    RECRUITING

    Duarte, California, 91010, United States

  • Ohio State University Comprehensive Cancer Center

    RECRUITING

    Columbus, Ohio, 43210, United States

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