Ohio State University Comprehensive Cancer Center

This early-stage study is testing a new type of personalized cell therapy for adults with aggressive brain tumors that have returned after prior treatment. Doctors take a patient's own immune cells, modify them in a lab to better target the cancer, and then infuse them back into …

This study is testing a new approach for treating HPV-linked throat cancer. It uses a blood test to see if patients can safely receive a lower dose of radiation and chemotherapy, aiming to control the cancer while reducing side effects. The trial will enroll about 45 adults with …

This early-stage trial is testing the safety and best dose of a new type of CAR-T cell therapy designed to attack three different proteins (CD19, CD20, and CD22) found on cancer cells. It is for adults with certain aggressive blood cancers like non-Hodgkin lymphoma, acute lymphob…

This study is comparing two hormone therapies for prostate cancer to see if one is better for heart health. Men with intermediate-risk prostate cancer will receive standard radiation and be randomly assigned to take either a daily pill (relugolix) or get an injection every 3 mont…

This early-stage study is testing a new combination of two drugs, osimertinib and tegavivint, for people with a specific type of advanced lung cancer that has spread. The main goal is to find the safest and most effective dose of the drug pair. Researchers will also check if the …

This early safety study is testing whether delivering heated chemotherapy directly into the abdomen during surgery is safe for patients with advanced ovarian, fallopian tube, or peritoneal cancer. The trial compares two approaches: giving standard chemotherapy the day before surg…

This study is testing whether a patient's body position (lying down, sitting, or moving freely) affects how long they can hold a liquid BCG treatment inside their bladder. Researchers want to see if changing position helps patients, especially those with limited mobility or stron…

This study is testing whether taking probiotic supplements during chemotherapy can help improve gut and vaginal bacteria health in women with advanced or recurrent ovarian cancer. Researchers want to see if these supplements can reduce side effects, improve quality of life, and p…

This study is testing whether adding a second drug to acalabrutinib helps achieve deeper remission in people with previously untreated chronic lymphocytic leukemia (CLL). After one year on acalabrutinib alone, participants will be randomly assigned to receive either obinutuzumab …

This study is testing a less invasive robotic surgery to remove benign and cancerous tumors in the mouth and throat. It aims to see if this approach is feasible and leads to fewer side effects and a better recovery for patients. The study will enroll people with various head and …

This study is testing whether following a strict high-fat, low-carbohydrate (ketogenic) diet is safe and feasible for patients with advanced melanoma or kidney cancer who are receiving immunotherapy. Researchers want to see if changing the body's main fuel source from sugar to fa…

This early-stage trial is testing whether combining an immunotherapy drug called pembrolizumab with surgery and targeted radiation can better control head and neck cancers that have returned or didn't fully respond to previous treatments. The study aims to find the safest way to …

This study is testing a new type of PET/CT scan to see if it can create clearer pictures of soft tissue sarcoma tumors. Researchers want to know if this scan, which uses a radioactive tracer called 68Ga-DOTATATE, works better than standard scans. The goal is to improve diagnosis …

This study is testing whether a specific diet designed to lower insulin levels in the blood can help reduce the risk of breast cancer in women who are at high risk. Researchers will work with 30 postmenopausal women to see if this eating plan is practical to follow and if it lead…

This study aims to understand why graduate students use oral nicotine pouches and test social media messages that could prevent addiction. Researchers will survey 2,000 Ohio State University graduate students about their habits and perceptions, then test different warning message…

This study is testing different ways to help more people in Appalachian communities complete colon cancer screening. Researchers are mailing two types of home test kits (standard and enhanced) and providing support through either phone calls or text messages. The goal is to find …

This study tests if specially designed messages can help young women drink less alcohol and better understand the link between alcohol and breast cancer risk. 500 women aged 18-25 who drink alcohol will receive either these new messages or general health information for six weeks…

This study is testing a community program designed to help more low-income and uninsured women get screened for breast, cervical, and colorectal cancer. The program works with clinics, healthcare providers, patients, and entire communities through education, reminders, and outrea…

This study is testing whether a patient navigation program can help women at high risk for breast cancer access and use recommended prevention strategies. The program provides information and monthly phone support to help participants understand their risk and options like geneti…

This study is testing if a structured bowel management program that includes a special rectal enema works better than standard medications alone for people suffering from bowel problems after rectal cancer surgery. The trial will involve 80 adults who still have moderate to sever…

This study is testing whether a vaginal hormone treatment called DHEA can help improve vaginal health and reduce discomfort for women who have had radiation therapy for certain gynecologic or gastrointestinal cancers. Radiation can cause symptoms like vaginal dryness, pain during…

This study is testing whether following a specific healthy eating plan called the MIND diet can help reduce thinking and memory problems (often called 'chemobrain'), fatigue, and other symptoms in women undergoing chemotherapy for triple-negative breast cancer. Researchers will c…

This study is testing whether special breathing exercises can help women feel less short of breath and more active during chemotherapy for early-stage breast cancer. Participants will use a small handheld device that makes breathing in a little harder, which may strengthen their …

This early study is testing whether a pill or a foam version of the hair growth drug minoxidil works better to treat hair loss caused by hormone therapy in breast cancer patients. It will involve about 50 women with stage I-IV breast cancer who are experiencing this side effect. …

This study is testing whether a partnered Argentine Tango dance program can help breast cancer survivors who have lasting numbness, tingling, and balance problems from chemotherapy. Researchers will enroll 140 participants to see if this social, non-drug activity can reduce sympt…

This study is testing whether a numbing cream called EMLA can reduce the brief pain patients feel from injections during a lymph node mapping procedure for skin cancer. About 100 adults with melanoma, Merkel cell, or squamous cell skin cancer will be randomly assigned to use eith…

This study is testing whether a special breathing muscle training program can help obese breast cancer survivors exercise for longer periods and feel less tired. Researchers will compare a real breathing training program to a fake one, followed by exercise for all participants. T…

This study is testing whether following a specific diet can help protect memory and thinking skills in women undergoing treatment for breast cancer. Researchers want to see if the MIND diet, which focuses on brain-healthy foods, can reduce the 'chemo brain' side effects that many…

This study is testing whether a 10-week stress reduction and support program is practical and helpful for patients with triple-negative breast cancer. The program teaches relaxation, coping skills, and problem-solving, while also connecting participants with social workers to hel…

This study is testing whether adding mental health support to standard cancer care helps patients with early-stage pancreatic cancer. Participants will have weekly video sessions with a psychologist during their pre-surgery chemotherapy or radiation treatment. The goal is to see …

This large Ohio study aims to learn if advanced genetic testing of tumors helps people with advanced lung cancer live longer or have better quality of life. It compares two approaches: usual care versus care that includes detailed genetic testing to guide treatment choices. The s…

This study aims to understand if vaping exposes young adults to heavy metals and affects their breathing. Researchers will test saliva for metals and measure lung function before and after a 30-minute vaping session. The study observes 100 regular e-cigarette users aged 18-29 to …

This study is creating a large registry of patients in Ohio with multiple myeloma and related blood disorders. Researchers will track patients' treatments, health outcomes, and quality of life over time to understand these diseases better. The registry also helps connect patients…

This study aims to understand how the physical cut of tobacco and the chemical form of nicotine make moist snuff more addictive. Researchers will have 80 adult users from Appalachian regions try different snuff products during five visits to measure how these features affect use …

This study aims to understand if reducing nicotine in filtered little cigars makes them less addictive and harmful. Researchers will compare how 50 current cigar users smoke their usual cigars versus study cigars with normal and very low nicotine. They will measure puffing habits…

This study is creating a detailed health record registry for people with bone or soft tissue tumors. It aims to collect information from up to 1,500 patients to help researchers identify patterns and factors linked to survival and treatment response. The goal is to build a resour…

This study aims to understand how using oral nicotine pouches (ONPs) affects alcohol drinking in young adults. Researchers will see if the nicotine strength or flavor of the pouches changes how much or how long participants drink. The findings could help shape future rules about …

This research study aims to understand how synthetic cooling additives in e-cigarettes affect how people perceive and use these products, and what chemicals they're exposed to. Researchers will recruit 300 young adult e-cigarette users to test different flavored e-cigarettes with…

This research study aims to understand how different claims on nicotine product packaging affect people's attention and perceptions. Researchers will show 450 young adults and adult tobacco users various product images while tracking their eye movements and measuring their physic…

This study aims to understand how breast cancer treatment affects sleep patterns and quality. Researchers will follow 100 patients with early-stage breast cancer, having them wear sleep trackers and complete surveys from treatment through recovery. The goal is to identify factors…

This study aims to understand how insurance delays affect patients with advanced skin cancers who need treatment before surgery. Researchers will follow 70 patients to track the time and costs involved in getting insurance approval for both standard and off-label drug treatments.…

This study aims to better understand melanoma by collecting and storing blood and tumor samples from patients and healthy individuals. Researchers will analyze these samples to learn how melanoma develops and behaves, hoping to discover new ways to diagnose or treat the disease i…

This study is collecting information to understand how well patients with spine tumors do after receiving a specific treatment combination: surgery to relieve pressure followed by radiation therapy. Researchers will follow 3,000 adults to see how long they live, if the cancer in …

This study examines how different flavors and cooling sensations in nicotine pouches affect their appeal to smokers. Researchers want to understand if these features make pouches more satisfying or help reduce cigarette cravings. The findings could help shape future regulations a…

This study aims to learn from people living with advanced breast cancer and their caregivers about their experiences with care and support. Researchers will survey and interview 50 participants across four groups to understand what has been helpful, what has been difficult, and w…