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Nicotine pouches vs. patches: can they help appalachian smokers quit cigarettes and cut cancer risk?

NCT ID NCT06763536

Recruiting now Disease control Sponsor: Ohio State University Comprehensive Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 30, 2026 · Last updated Jul 01, 2026 · Updated 1 time

Summary

This trial compares oral nicotine pouches (like ZYN) with standard nicotine replacement therapy (patches and lozenges) to help smokers in rural Appalachia reduce or stop cigarette use. The goal is to lower the high rates of lung and oral cancers linked to smoking in this region. Participants must be 21 or older, smoke at least 5 cigarettes daily, and live in a rural Appalachian county.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
oral nicotine pouch (ZYN), nicotine patch, nicotine lozenge
What this could lead to
If effective, oral nicotine pouches could offer a less harmful alternative to cigarettes, helping smokers in rural Appalachia reduce their cancer risk.
What could go wrong
This is a behavioral intervention trial, not a treatment for cancer itself. Results may vary, and long-term health benefits are not guaranteed.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

squamous cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CIGARETTE SMOKING-RELATED CARCINOMA

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Ohio State University Comprehensive Cancer Center

    RECRUITING

    Columbus, Ohio, 43210, United States

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