Ohio State University Comprehensive Cancer Center

This trial compares oral nicotine pouches (like ZYN) with standard nicotine replacement therapy (patches and lozenges) to help smokers in rural Appalachia reduce or stop cigarette use. The goal is to lower the high rates of lung and oral cancers linked to smoking in this region. …

This trial investigates whether adding papaverine—a drug traditionally used as a muscle relaxant—to standard chemoradiation can improve treatment for people with stage II to III non-small cell lung cancer. Papaverine targets the energy factories inside cancer cells (mitochondria)…

This study tests whether taking probiotic supplements can improve the gut and vaginal microbiome in women with advanced or recurrent ovarian cancer who are receiving platinum-based chemotherapy. About 161 participants will be randomly assigned to receive either probiotics or a pl…

This study tests a procedure that uses a thin, flexible tube with a camera and ultrasound to guide a needle into pancreatic cysts. Chemotherapy drugs are injected directly into the cyst to shrink or destroy precancerous cells. The goal is to prevent these cysts from developing in…

This early-phase trial is testing a new type of immunotherapy called anti-GARP CAR T-cell therapy for people with recurrent high-grade gliomas (aggressive brain tumors). Researchers will take a patient's own immune cells, modify them in the lab to target a protein called GARP fou…

This early-phase trial tests a new type of immunotherapy called TriCAR19.20.22 T cells for people with certain blood cancers (non-Hodgkin lymphoma, acute lymphoblastic leukemia, and chronic lymphocytic leukemia) that have returned or not responded to standard treatments. The ther…

This study is for people with cancer that has spread to the spine. It tests whether adding a procedure called vertebroplasty (which repairs broken spine bones) to standard radiation and immunotherapy can help prevent fractures and improve survival. About 200 participants will rec…

This study tests a drug called Vyxeos in adults with acute myeloid leukemia (AML) whose cancer did not go away after standard chemotherapy. Vyxeos combines two chemo drugs inside a tiny fat bubble (liposome) to deliver them more effectively. The trial will check for side effects …

This study looks at whether flavored e-cigarettes (tobacco vs. non-tobacco) or nicotine patches and lozenges work better to help people stop smoking regular cigarettes. Researchers will track how many participants quit smoking completely over 7 days. The goal is to find out which…

This study tests whether a blood test that detects HPV DNA can guide doctors to safely use a lower dose of radiation for people with HPV-related throat cancer. About 45 adults with early-stage HPV-positive oropharyngeal cancer will receive radiation and chemotherapy. The goal is …

This study tests a less invasive procedure called endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) to treat pancreatic cysts that have a high risk of turning into cancer. About 84 adults with pancreatic cysts at least 2 cm in size and showing concerning features wil…

This phase 2 trial tests two different drug combinations in people with untreated chronic lymphocytic leukemia (CLL). Participants first take acalabrutinib alone, then are randomly assigned to add either obinutuzumab or venetoclax. The goal is to see which combination better clea…

This early-phase trial is testing whether giving heated chemotherapy directly into the abdomen during surgery is safe for people with advanced ovarian, fallopian tube, or peritoneal cancer. Participants will receive standard chemotherapy before surgery, and then either heated che…

This study is testing a less invasive robotic surgery called TORS for people with head and neck tumors. The goal is to see if it is safe and effective, with fewer side effects and faster recovery than traditional surgery. Up to 600 participants will be enrolled, and their outcome…

This early-phase trial is testing whether adding the immunotherapy drug pembrolizumab (Keytruda) to radiation therapy before and during surgery can help treat head and neck cancers that have persisted or come back. About 45 adults with resectable tumors will receive the combinati…

This early-phase trial is testing two drugs, osimertinib and tegavivint, as a first treatment for people with a specific type of advanced lung cancer (EGFR-mutant NSCLC that has spread). The goal is to find the best dose and see if the combination is safe and shrinks tumors. Abou…

This study tests whether a high-powered imaging technique called ultra-high resolution optical coherence tomography (OCT) can detect tiny, early-stage pancreatic cancers in tissue samples removed during surgery. Researchers will compare OCT images with standard lab analysis and a…

This study is testing whether a special PET/CT scan using a tracer called 68Ga-DOTATATE can improve the detection of soft tissue sarcomas. About 30 adults with this cancer will receive the scan to see if it highlights tumors better than standard imaging. The goal is to determine …

This study tests whether specially designed messages about alcohol and breast cancer can help young women ages 18-25 drink less and understand the risks. About 500 women who drink alcohol will receive these messages and report their drinking habits. The goal is to see if awarenes…

This study tests ways to improve colorectal cancer screening in Appalachia by mailing fecal immunochemical test (FIT) kits to 500 people who are due for screening. Some participants get an enhanced kit with a video brochure and gloves, plus phone or text reminders. The goal is to…

This study tests a community program to increase cancer screening rates among low-income women in Ohio. The program includes patient education, coaching calls, and community outreach. Researchers will compare screening rates between groups that start the program early versus late…

This study tests whether a 10-week stress reduction program is doable and helpful for people with triple negative breast cancer. The program includes relaxation, coping skills, and social support, and also addresses basic needs like utilities or transportation. Researchers will m…

This study tests a new tool called the Buckeye Quit Stick to help smokers with lung cancer quit. The stick replaces the hand-to-mouth habit of smoking without using medicine. About 30 adults will try it for 6 months to see if it helps them stay smoke-free.

This study tests two programs—one in-person and one virtual—that combine exercise and relaxation techniques for people about to have lung cancer surgery. The goal is to see if starting these programs before surgery helps patients recover faster, feel better, and possibly shorten …

This study tests an online cognitive training program called I-CAN in 90 adults with relapsed multiple myeloma or B-cell non-Hodgkin lymphoma who are about to receive CAR-T cell therapy. The training aims to reduce the memory, attention, and thinking problems that often follow ca…

This study tests if listening to a guided meditation before cancer surgery can lower anxiety more than sitting in silence. About 300 adults scheduled for cancer surgery will take part. Researchers will measure anxiety levels and also track pain medicine use after surgery to see i…

This pilot study is testing whether a brief, clothed upper body massage given after each radiation treatment can reduce muscle and joint pain, improve arm and shoulder mobility, and enhance quality of life for breast cancer patients. About 55 women receiving curative radiation wi…

This phase 2 trial tests whether a vaginal DHEA suppository can safely improve vaginal health in 25 women who had radiation for gynecologic, anal, or rectal cancer. Radiation often causes dryness, burning, and pain, similar to menopause. DHEA is a hormone replacement that may hel…

This study compares a bowel management program that includes a retrograde rectal enema (RRE) against standard medical care (fiber, loperamide, pelvic floor therapy) for people with low anterior resection syndrome (LARS) after rectal cancer surgery. Researchers will enroll 80 adul…

This study tests whether a simple breathing exercise using a small handheld device can strengthen breathing muscles and reduce shortness of breath in women receiving chemotherapy for early-stage breast cancer. About 58 participants will use the device daily and be monitored for c…

This study tests whether EMLA numbing cream can reduce pain from Technetium 99 injections used in lymphoscintigraphy, a standard mapping procedure for skin cancers like melanoma. About 100 adults with skin cancer will receive either EMLA cream or a placebo before the injection. T…

This early trial tests whether minoxidil (Rogaine) — applied to the scalp or taken as a pill — can help with hair loss caused by hormone therapy in breast cancer patients. About 50 women with stage I-IV breast cancer who report hair thinning since starting endocrine therapy will …

This study tests whether adding psychosocial (emotional) support to standard prehabilitation helps patients with localized pancreatic cancer during neoadjuvant therapy (chemotherapy/radiation before surgery). Sixty adults will receive nutritional advice, physical therapy, and psy…

This study tests whether a 12-week MIND eating plan can reduce memory problems, fatigue, and other symptoms in women with stage II-III triple-negative breast cancer during chemotherapy. About 60 women will be randomly assigned to either the MIND diet or general health coaching, w…

This study tests whether adapted Argentine Tango dancing can reduce nerve damage symptoms caused by breast cancer chemotherapy. About 140 survivors who completed taxane-based chemo at least 3 months ago will take 16 dance sessions over 8 weeks. Researchers will measure changes in…

This pilot study tests whether a diet called MIND (rich in berries, leafy greens, and fish) can help protect memory and thinking in women with breast cancer who are starting chemotherapy. 43 postmenopausal women with stage II-IV breast cancer will receive either nutrition counsel…

This phase 1 trial at Ohio State University is studying how nicotine analogs compare to regular nicotine in e-cigarettes. Researchers want to understand if these newer chemicals are just as addictive and what they do to the heart and blood vessels. The study involves 70 adult e-c…

This study tracks 70 skin cancer patients to see how long it takes to get insurance approval for off-label neoadjuvant therapy (treatment before surgery). Researchers will measure approval times, out-of-pocket costs, and whether delays lead to worse surgical outcomes. The goal is…

This study uses virtual reality to show people two versions of the same neighborhood—one clean and tidy, the other with litter and graffiti—to see how these scenes affect stress and emotions. Researchers will measure heart rate, skin sweat, and feelings of anxiety in 32 adults wh…

This large study in Ohio is looking at whether advanced genomic testing and immunotherapy decision support can help people with stage IV non-small cell lung cancer live longer and have a better quality of life. Researchers will compare standard care with a more personalized appro…

This study follows 960 women at high risk for breast cancer to see if their diet's inflammatory potential is linked to cancer risk. Participants complete questionnaires and physical exams over time. The goal is to identify modifiable risk factors to improve prevention and early d…

This study tests a program called CUSP2CT, designed to increase the number of racial and ethnic minorities referred to and enrolled in cancer clinical trials. The program involves educational sessions, discussions, and patient navigation. Researchers will track changes in referra…

This study tests whether a mobile app called MyCap can help track the time patients spend on pancreatic cancer treatment, including appointments, travel, and waiting. Thirty adults with pancreatic cancer who are on active treatment will use the app daily for 8 weeks. The goal is …

This study looks at how the amount and type of nicotine in e-cigarettes influence addiction and potential harm. Researchers will measure nicotine levels in the blood, puffing habits, and cell damage in 375 young adults and older smokers. The goal is to gather information that cou…

This study looks at whether oral nicotine pouches (like ZYN) can be a good substitute for cigarettes or smokeless tobacco. Researchers will test different nicotine levels and forms to see which ones reduce cravings and appeal to users. 160 adult tobacco users will try the pouches…

This study is creating and testing a mobile health app designed to help colorectal cancer survivors and their family caregivers follow healthy lifestyle recommendations. Researchers will work with 70 participants to see if the app is easy to use and acceptable. The goal is to imp…

This study is for people with advanced cancer. Researchers will use a special genetic test on tumor samples to look for DNA changes. The goal is to see if these test results can help doctors choose a more personalized treatment. Up to 1000 participants will be enrolled, and the s…

This study collects blood and tumor samples from 99 breast cancer patients to examine how certain immune cells (myeloid-derived suppressor cells) affect the function of natural killer cells. The goal is to understand immune system interactions and potentially predict chemotherapy…

This study is creating a database of up to 5,000 people in Ohio with plasma cell disorders like multiple myeloma and amyloidosis. Researchers will track treatments, outcomes, and quality of life, while also offering patients access to expert consultations and information about su…

This study looks at what helps and what is hard for people with advanced breast cancer, and what kind of support they still need. Researchers will talk to 50 patients and review their medical records to understand their experiences. The goal is to learn how to improve care and su…

This study tests whether a patient's position (lying down, sitting up, or moving freely) affects how long the BCG medicine stays in the bladder during treatment for non-muscle invasive bladder cancer. Researchers will measure dwell time in 40 patients under three different positi…

This study compares two hormone-lowering drugs, Orgovyx and Eligard, in men with prostate cancer who are also getting radiation therapy. The goal is to see which drug has less impact on heart function and overall heart health. About 70 participants will undergo heart tests, exerc…

This study surveys 2,000 Ohio State graduate students to understand how social pressures and health beliefs influence their use of oral nicotine pouches. Researchers will test different types of warning messages to see which ones best reduce the desire to try these products. The …

This study collects blood and tumor samples from 1,000 people with melanoma and healthy volunteers. Researchers will analyze these samples to learn more about what causes melanoma and how tumors behave. The goal is to find new markers that could lead to better diagnosis or treatm…

This study is creating a detailed health record database for 1500 people diagnosed with bone or soft tissue tumors. The goal is to collect high-quality information that researchers can use to better understand these rare diseases. No new treatments or medications are being tested…

This study explores how claims on nicotine products (like nicotine strength or source) affect what people notice and think. Researchers will track eye movements and heart rate in 450 participants, including young adults who don't use tobacco and adults who do. The goal is to unde…

This study looks at how sleep changes in women with early-stage breast cancer during treatment. Researchers will track sleep patterns and check for links to stress, social support, and living environment. About 100 participants will wear a sleep monitor and answer surveys before,…

This study looks at how the cooling sensation in oral nicotine pouches (like ZYN) influences smokers' appeal and cravings. Thirty adult smokers will try different pouches and rate their experience. The goal is to understand if these products could help people switch from cigarett…

This study looks at how the cut (fine vs. long) and nicotine form in moist snuff affect how addictive it is. Researchers will study 80 moist snuff users to see how these features influence how much people use it, how fast nicotine enters the body, and how appealing the product is…

This study is following 3,000 adults with spine tumors (either primary or that have spread from elsewhere) who undergo surgery to relieve pressure on the spine, followed by radiation. Researchers are tracking how long patients live, whether the tumor stays under control, and how …

This study looks at how young adults use oral nicotine pouches (like ZYN) and alcohol together. Researchers want to know if the nicotine strength or flavor of the pouch affects how much alcohol people drink. Twenty participants aged 21-30 who use nicotine pouches daily and drink …

This study tests whether very low nicotine little cigars change how people smoke and affect their lungs compared to regular cigars. About 50 adult little cigar smokers will attend three 4-hour visits at Ohio State University. They will fill surveys, give blood, do breathing tests…