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Could a hormone cream ease Post-Radiation vaginal pain? new trial investigates

NCT ID NCT07407647

Recruiting now Symptom relief Sponsor: Ohio State University Comprehensive Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 trial tests whether a vaginal DHEA suppository can safely improve vaginal health in 25 women who had radiation for gynecologic, anal, or rectal cancer. Radiation often causes dryness, burning, and pain, similar to menopause. DHEA is a hormone replacement that may help. The study checks for side effects and changes in the vaginal microbiome.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Prasterone (DHEA) vaginal suppository
What this could lead to
If it works, this could offer a hormone-based option to relieve vaginal discomfort and improve quality of life for women after pelvic radiation.
What could go wrong
This is a small early-phase trial with only 25 participants, so results may not apply to everyone. DHEA can cause side effects like vaginal discharge or irritation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

anal carcinoma anus neoplasm cervical carcinoma female reproductive organ cancer rectal carcinoma rectal neoplasm Uterine Cervical Neoplasms vaginal cancer vaginal carcinoma vulva cancer vulvar carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANAL CARCINOMA CERVICAL CARCINOMA MALIGNANT FEMALE REPRODUCTIVE SYSTEM NEOPLASM RECTAL CARCINOMA VAGINAL CARCINOMA VULVAR CARCINOMA

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Ohio State University Comprehensive Cancer Center

    RECRUITING

    Columbus, Ohio, 43210, United States

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