Better swab, better catch: study aims to sharpen anal cancer screening
NCT ID NCT02816879
First seen Jul 07, 2026 · Last updated Jul 08, 2026 · Updated 1 time
Summary
This study compares different ways to collect anal cell samples and different HPV tests to see which combination best predicts high-grade anal dysplasia, a pre-cancerous condition. Researchers are enrolling men who have sex with men, including those with and without HIV. The goal is to make screening more accurate so that those at highest risk can be identified and treated earlier.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could lead to simpler, more accurate screening to catch pre-cancerous changes early in men at higher risk.
- What could go wrong
- This is an observational comparison of existing tests, not a treatment trial. Results may not change current screening guidelines.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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415 people
The number who actually took part.
- Started
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Aug 2013
- Expected to finish
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Jun 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Male participants only
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Males who self-identify as having had or currently having sex with men; both human immunodeficiency virus (HIV)-infected and HIV-uninfected subjects are being enrolled
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Desert AIDS Project
Palm Springs, California, 92262, United States
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Los Angeles Gay and Lesbian Center
Los Angeles, California, 90028, United States
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UCLA / Jonsson Comprehensive Cancer Center
Los Angeles, California, 90095, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can new HIV drug mixes keep more children Virus-Free?
- Could Self-Swabs make anal cancer screening easier for people with HIV?
- Home test kits could transform STI screening for sex workers
- Can surveillance catch birth defects early in HIV-Affected pregnancies?
- Could organs from HIV-Positive donors be safe for recipients with HIV?