Jonsson Comprehensive Cancer Center

This study is for men whose prostate cancer has returned and spread to a few other places in the body. It compares two different radioactive drugs, each designed to seek out and deliver radiation directly to cancer cells. Both drugs are given along with a short, precise course of…

This study is testing whether adding a maintenance drug called acalabrutinib after cellular therapies (like stem cell transplants or CAR-T cell therapy) can help prevent aggressive lymphoma from returning in patients at very high risk of relapse. Researchers want to see if this e…

This early safety study is testing whether a diabetes drug called dapagliflozin is safe to give to people with early-stage lung cancer before they have surgery. Researchers want to see if taking the pill for 30 days before the operation helps make the surgery more effective by po…

This study is testing whether adjusting radiation treatment plans daily using real-time MRI or CT scans can reduce side effects for men with localized prostate cancer. Researchers will compare this 'adaptive' approach to standard radiation that uses a fixed plan. The goal is to s…

This early-stage trial is testing whether a short, intense course of radiation followed by several months of chemotherapy can effectively shrink rectal tumors. The main goal is to see if this approach can eliminate the cancer enough that patients can avoid having their rectum sur…

This study is testing whether adding two new drugs (zimberelimab and quemliclustat) to standard chemotherapy can help people with pancreatic cancer that is difficult or impossible to remove with surgery. The new drugs aim to boost the immune system's ability to fight the cancer. …

This study is testing an immunotherapy drug called ivonescimab for people with advanced thymic carcinoma, a rare cancer, who have already tried other treatments. The main goal is to see if the drug helps shrink tumors and is safe for patients. Participants will receive the drug t…

This study is testing a procedure called radioembolization for people with early-stage kidney cancer who are not ideal candidates for standard surgery. Doctors inject millions of tiny radioactive glass beads directly into the artery feeding the tumor to deliver a concentrated dos…

This study is testing a new clinic-wide system designed to help patients get their recommended follow-up colonoscopy on time. It targets people aged 45-75 who have had high-risk colon polyps removed, as they need a repeat colonoscopy in 3 years to prevent cancer. The system combi…

This study is testing a shorter, 5-day radiation treatment given before surgery for soft tissue sarcoma, a rare cancer. The goal is to see if this faster approach is as effective at controlling the cancer while causing fewer long-term side effects like scarring or stiffness. Rese…

This study is testing whether giving a second course of a targeted radiation drug can help men with advanced prostate cancer that has spread and stopped responding to standard hormone therapy. The treatment, called 177Lu-PSMA-617, is given by IV and seeks out and delivers radiati…

This study is testing a newer targeted drug called trastuzumab deruxtecan, given alone or with a hormone-blocking pill (anastrozole), before surgery for early-stage breast cancer. The goal is to see which approach is better at shrinking or eliminating the tumor. It is for people …

This study is testing a type of internal radiation therapy for kidney cancer tumors that are too large or difficult to remove with surgery. Doctors temporarily place tiny radiation sources directly into the tumor to try to stop its growth. The research aims to see if this approac…

This study is for men with advanced prostate cancer that has spread and stopped responding to standard hormone therapy and chemotherapy. It compares the current standard treatment schedule (6 fixed doses) to a new, flexible schedule (up to 12 doses with breaks). The goal is to se…

This early-stage trial is testing a new oral drug called ERAS-801 in adults with a specific type of recurrent brain cancer (glioblastoma). The main goals are to check the drug's safety and see how it affects the tumor's energy use. Participants take the pill daily for a short tim…

This study is testing if a drug called pembrolizumab can help the body's immune system clear high-grade abnormal cervical cells (CIN 2/3) before they turn into cancer. It will involve about 25 women who will receive the drug through an IV every six weeks for about six months. The…

This study is testing a new clinic-wide program designed to help more patients get a follow-up colonoscopy after receiving an abnormal stool test result. The program involves better care coordination, patient education, and communication between doctors. Researchers will compare …

This study is testing an investigational cancer drug called tarlatamab in people with advanced tumors that have a specific protein called DLL3. The goal is to see if the drug is effective and safe for these hard-to-treat cancers, which include certain neuroendocrine tumors. Parti…

This study is testing a two-part treatment for high-risk cancer of the kidney's drainage system (upper tract urothelial carcinoma). It gives patients a combination of two immunotherapy drugs (pembrolizumab and enfortumab vedotin) before surgery to remove the kidney and ureter, ai…

This study is testing a more precise form of radiation therapy for prostate cancer that hasn't spread. It uses real-time imaging to track the prostate's movement during treatment, allowing doctors to deliver radiation more accurately. The goal is to reduce common side effects lik…

This study is testing two new types of MRI scans to see if they can better tell the difference between a brain tumor that has grown back and harmless scar tissue caused by past radiation treatment. Currently, standard scans often look the same, making it hard for doctors to decid…

This large study is testing whether an FDA-approved artificial intelligence (AI) tool helps radiologists do a better job when reading screening mammograms. It will involve 400,000 mammograms across six major US health systems. For each mammogram, a computer will randomly decide i…

This early study is testing a new radioactive tracer called 99mTc-PSMA-I&S. It is designed to help surgeons better see and remove prostate cancer that has spread to lymph nodes during an operation. The study will enroll 30 men with prostate cancer who are already scheduled for ly…

This study is testing a new blood test to diagnose thyroid cancer. Researchers will analyze tiny particles in the blood from 250 people having thyroid surgery to see if they can accurately spot cancer. The goal is to create a less invasive alternative to needle biopsies for diagn…

This study is testing a new type of PET scan to see if it can detect lung cancer earlier and more accurately. Researchers will give 60 participants a special radioactive glucose tracer and then perform a PET/CT scan. The goal is to see if this new method is safe and works better …

This study is testing a new type of imaging scan to see if it can accurately find prostate cancer that remains or returns after a man has had a targeted, less-invasive treatment. Men who had a focal therapy (like laser or ultrasound) for prostate cancer within the past 6 months t…

This study is testing whether a new type of PET scan, which uses a radioactive tracer to highlight prostate cancer cells, can better guide doctors when taking biopsy samples from the prostate. Researchers will compare this new method to the current standard of using MRI scans for…

This study is testing whether people who get screened for breast or lung cancer, or their supportive friends and family, can encourage others to get screened too. Researchers want to see if this 'sphere of influence' approach can increase screening rates, especially for lung canc…

This study is testing a personalized, high-dose radiation schedule for people with advanced head and neck cancer who cannot have standard treatments. The goal is to see if this approach can shrink tumors more effectively and provide better pain and symptom relief, while aiming to…

This study is testing whether a more precise, MRI-guided radiation technique can better protect the nerves and blood vessels needed for erectile function in men with prostate cancer. Researchers will compare this advanced method to standard radiation in 200 patients, measuring se…

This study is testing whether a virtual reality meditation app or relaxing music works better to reduce anxiety and pain during breast biopsies. Researchers will compare these two approaches against standard care in 600 women undergoing the procedure. The goal is to find non-medi…

This study aims to learn why some advanced prostate cancers become resistant to a targeted radiation treatment called 177Lu-PSMA therapy. Researchers will take small tissue samples (biopsies) from 30 patients before and during their treatment to analyze the cancer cells. The goal…

This research study aims to understand how inherited genetic mutations affect cancer risk, development, and treatment response. Researchers will collect blood and saliva samples from 2,000 cancer patients to analyze their DNA. The goal is to identify genetic patterns that could h…

This study is testing a new type of combined MRI and PET scan to see if it can accurately measure how brain tumor cells use energy (a process called glycolysis). Researchers will compare scan results from 50 adults with glioblastoma to actual tissue samples taken during their pla…

This study aims to see if growing tiny 3D models of a patient's bone cancer (called organoids) in a lab can help doctors predict which chemotherapy drugs will work best for them. Researchers will take tissue from biopsies or surgeries of 40 osteosarcoma patients and test differen…

This study aims to understand the biology of glioblastoma, a serious brain cancer, by analyzing MRI scans. Researchers will study 50 adults with this cancer who are scheduled for surgery. The goal is to find patterns in the scans that might predict which patients could benefit fr…

This study is testing three new types of MRI scans to see if they can help researchers understand the immune cells and environment around a brain tumor called glioblastoma. The goal is to find a less invasive way than surgery to learn why some of these tumors are resistant to tre…

This early-phase study is testing whether a new radioactive tracer, called Zr-89 crefmirlimab berdoxam, can help doctors see immune cells inside brain tumors using a PET scan. The goal is to see if this non-invasive scan can accurately show where immune cells are active, which co…