Jonsson Comprehensive Cancer Center

This study tests the safety and effectiveness of a treatment called radioembolization for people with early stage kidney cancer. Tiny glass spheres containing radioactive yttrium-90 are injected into the artery feeding the tumor to destroy it from inside. The trial will enroll 25…

This phase 2 trial tests a precise radiation technique called MRI-guided stereotactic body radiation therapy (SBRT) for people with sarcomas in the abdomen or pelvis. The radiation is given over 5 days, followed by surgery within 12 weeks. The goal is to safely deliver high-dose …

This phase II trial is testing a drug called ivonescimab in 25 people with thymic carcinoma, a rare cancer of the thymus gland that has already been treated. Ivonescimab is an immunotherapy that helps the body's immune system recognize and attack cancer cells. The main goal is to…

This trial tests a type of internal radiation called high-dose-rate brachytherapy for men with early-stage prostate cancer. The goal is to see if focusing radiation only on the tumor can control the cancer while causing fewer urinary and sexual problems than standard treatments. …

This study tests whether adding two new drugs (zimberelimab and quemliclustat) to standard chemotherapy can help shrink pancreatic tumors that are either borderline removable or have spread locally. About 56 adults with untreated pancreatic cancer will receive the combination. Th…

This study tests the drug tarlatamab in people with advanced tumors that have a protein called DLL3. The goal is to see if the drug can shrink or control these tumors. About 29 adults with stage IV cancer will receive tarlatamab, and researchers will track how well it works and a…

This phase 1 trial is testing whether fluoxetine (Prozac), a common antidepressant, can change the immune cells inside colorectal tumors. Ten patients with untreated colorectal cancer will take fluoxetine before surgery. Researchers will compare tumor samples taken before and aft…

This study tests a combination of two drugs, telisotuzumab vedotin and osimertinib, in people with a type of advanced lung cancer (NSCLC) that has stopped responding to osimertinib alone. The cancer must have a specific gene change (EGFR mutation) and high levels of a protein cal…

This early-phase trial tests the safety of a drug called ERAS-801 in 10 adults with recurrent glioblastoma, a fast-growing brain cancer. The drug targets a protein called EGFR that is overactive in many of these tumors. Researchers will also check if the drug affects tumor activi…

This early-phase trial tests whether a short course of radiation followed by chemotherapy can shrink advanced rectal tumors enough to avoid surgery. About 25 people with stage II or III rectal cancer will receive the treatment. The goal is to preserve the rectum and improve quali…

This study tests whether giving a second round of a radioactive drug called 177Lu-PSMA-617 can help men with advanced prostate cancer that no longer responds to hormone therapy. The drug targets and delivers radiation directly to cancer cells. Participants must have already had a…

This study is for people with advanced prostate cancer that has spread and stopped responding to standard treatments. It compares the usual fixed schedule of 6 doses of Lu-PSMA therapy to a flexible schedule that allows up to 12 doses with breaks (treatment holidays) based on how…

This phase II trial is testing whether the immunotherapy drug pembrolizumab (Keytruda) can treat high-grade cervical precancer (CIN 2/3 or carcinoma in situ). The study will enroll 25 women and measure how many have a complete response at 6 months. The goal is to see if this drug…

This study tests a new radiation approach for adults with soft tissue sarcoma, a type of cancer. Instead of weeks of daily radiation, patients receive higher doses over just 5 days before surgery. The goal is to see if this shorter course kills tumor cells effectively while causi…

This study tests whether the drug acalabrutinib, taken as a pill, can safely prevent relapse in people with very high-risk large B-cell lymphoma after they receive cell therapy (stem cell transplant or CAR T-cells). The trial will enroll 24 adults aged 18-70. Researchers will tra…

This early-phase study tests a type of internal radiation called brachytherapy for people with large kidney tumors (4-10 cm) that cannot be removed by surgery or ablation. A small radiation source is placed directly into the tumor to kill cancer cells. The goal is to see if this …

This study tests whether a diabetes drug called dapagliflozin is safe to give before surgery in people with early-stage lung adenocarcinoma. About 48 participants will take the drug for a short time before their planned surgery. The goal is to see if the drug can help make surger…

This phase 2 trial is testing whether giving two drugs—pembrolizumab and enfortumab vedotin—before and after surgery can improve outcomes for people with high-risk upper tract urothelial cancer. The drugs are designed to help the immune system attack cancer cells and deliver a ta…

This phase II trial is testing two radioactive drugs, 225Ac-PSMA-617 and 177Lu-PSMA-617, combined with precise radiation therapy for prostate cancer that has returned and spread to a few spots in the body. The drugs target a protein on cancer cells and deliver radiation to kill t…

This phase II trial is testing whether a targeted drug called trastuzumab deruxtecan (Enhertu), given alone or with anastrozole (Arimidex), can eliminate HER2-low, hormone receptor positive breast cancer before surgery. The study will enroll 88 people with early-stage breast canc…

This Phase II trial tests whether a special PET/CT scan using a radioactive tracer called 89Zr-DFO-girentuximab can find recurrent clear cell renal cell carcinoma after surgery better than standard contrast-enhanced CT. The tracer attaches to a protein (CAIX) on kidney cancer cel…

This study is testing whether new MRI techniques and artificial intelligence can improve how doctors diagnose prostate cancer. Researchers will enroll 275 men with suspected or confirmed prostate cancer. The goal is to make diagnosis more accurate and less invasive than current m…

This early trial is testing whether a special PET/CT scan using flotufolastat F-18 can better guide prostate biopsies than standard MRI. The study will enroll 30 men with suspicious MRI findings. Researchers will compare how often the new method detects aggressive prostate cancer…

This study is testing whether a blood test can diagnose thyroid cancer as accurately as a traditional biopsy. Researchers will analyze tiny particles called extracellular vesicles from blood and tissue samples of 250 adults with thyroid nodules or cancer. The goal is to find a le…

This study tests two advanced MRI techniques to better tell apart brain tumors that have come back from tissue damage caused by radiation therapy. About 42 adults with brain metastases will be scanned before surgery or radiation. The goal is to help doctors make more accurate tre…

This large trial compares standard mammogram reading by radiologists to reading with the help of an FDA-approved AI tool. The goal is to see if AI improves cancer detection and reduces unnecessary callbacks. About 400,000 adult women across six U.S. health systems will participat…

This study tests a new PET scan tracer called Me-4FDG to see if it can find lung cancer earlier and more accurately. About 60 adults with lung nodules will get the tracer and a PET scan. The goal is to improve early diagnosis and reduce unnecessary procedures.

This phase II trial is testing whether a special PET/CT scan using flotufolastat F 18 can accurately find prostate cancer that remains or returns after focal therapy (such as laser or freezing). The study will enroll 81 men who had focal therapy 6 to 36 months ago. If the scan wo…

This study tests whether using community health advocates—people who encourage their friends and family—can increase screening for breast and lung cancer. Researchers will enroll 800 participants and provide educational materials, patient navigation, and surveys. The goal is to s…

This study is testing a weight loss program that uses a smartphone app and a coach to help teens and young adults who are overweight after a stem cell transplant. The goal is to see if the program can help them lose weight and build healthy eating habits. About 20 people who are …

This trial tests whether using daily MRI or CT scans to adjust radiation plans in real time can lower side effects for men with localized prostate cancer. 186 participants will receive standard stereotactic body radiation therapy (SBRT) either with or without daily plan adaptatio…

This study tests a personalized radiation therapy called PULSAR for people with head and neck cancer who cannot have or choose not to have standard treatment. The goal is to see if giving fewer, larger doses of radiation that adapt to changes in the body can better control tumors…

This study compares virtual reality (VR) and music relaxation to standard care for reducing anxiety and pain in women undergoing breast biopsies. About 600 women will be randomly assigned to one of three groups: VR, music, or usual care. Researchers will measure anxiety and pain …

This study tests a precise radiation technique called neurovascular-sparing SBRT for men with prostate cancer. The goal is to see if customizing each treatment session based on MRI images can better protect the nerves and blood vessels needed for erections, compared to standard r…

This study tests a new way to deliver radiation for prostate cancer that hasn't spread. By using real-time motion tracking during treatment, doctors hope to target the tumor more precisely and reduce common side effects like urinary and bowel problems. About 80 men with early-sta…

This study looks at why some prostate cancers become resistant to a targeted radiation treatment called 177Lu-PSMA. Researchers will take small tissue samples (biopsies) from tumors in 30 patients before and after therapy. The goal is to find genetic changes that cause resistance…

This study follows men with low-risk prostate cancer who have chosen active surveillance—monitoring the cancer over time rather than treating it right away. Researchers will collect data for years to learn which signs predict that the cancer may become aggressive. The goal is to …

This study is testing whether growing a patient's osteosarcoma cells in the lab (as organoids) can predict which chemotherapy drugs will work best. Researchers will take tissue from routine biopsies or surgeries of 40 people with suspected or confirmed osteosarcoma. The goal is t…

This study looks at how endocrine therapy, a common breast cancer treatment, affects thinking and brain function in 120 survivors aged 35-65. Researchers will use brain scans and memory tests to compare survivors on therapy with healthy women. The goal is to understand if menopau…

This early-stage study is testing a radioactive imaging agent called 99mTc-PSMA-I&S in 30 men with prostate cancer who are scheduled for lymph node removal surgery. The goal is to see how well this agent can help surgeons detect cancer that has spread to the lymph nodes during th…

This study tests three advanced MRI methods to non-invasively look at the immune cells and proteins around glioblastoma tumors. Researchers will compare MRI results with tissue samples from 15 patients scheduled for surgery. The goal is to see if these scans can replace biopsies …

This study tests a clinic-wide program called Primary Care-GI Connect to improve follow-up colonoscopy rates in people who had an abnormal stool-based colorectal cancer screening test (FIT). The program helps coordinate care, standardize referrals, and educate patients. Researche…

This early-phase study tests a special PET imaging agent that highlights immune cells (CD8+ T-cells) in brain tumors. About 20 adults with brain tumors scheduled for surgery will receive an injection of the imaging agent before their PET scan. The goal is to see if this non-invas…

This study tests a program that uses reminders, scheduling help, and electronic health record tools to encourage patients with high-risk colon polyps to get a follow-up colonoscopy within 3 years. About 1,680 patients and their healthcare providers will take part. The goal is to …

This study looks at whether MRI scans and a protein called decorin can help identify which glioblastoma patients might benefit from a drug called bevacizumab. Researchers will collect tissue samples from 50 patients during surgery and compare them with MRI images. The goal is to …

This study looks at blood and saliva samples from 2000 people with cancer to find inherited genetic changes that may increase cancer risk, affect how tumors grow, or influence how well treatments work. Participants provide samples and allow researchers to analyze their DNA. The g…

This study tests a new combined MRI and PET scan that measures how active brain tumor cells are by looking at their energy use (glycolysis). Researchers will take small tissue samples during surgery to check if the scan matches the tumor's actual biology. The goal is to better id…