Jonsson Comprehensive Cancer Center

This study tests a drug called trastuzumab deruxtecan, which delivers chemotherapy directly to cancer cells with low levels of HER2, either alone or with anastrozole (a hormone blocker). The goal is to see if these treatments can eliminate all signs of cancer before surgery in pe…

This early-stage trial tests a new drug called ERAS-801 in 10 adults with a type of aggressive brain cancer (glioblastoma) that has come back or worsened. The drug targets a specific protein (EGFR) found on many of these tumor cells and is designed to reach the brain. The main go…

This study is for people with a type of advanced prostate cancer that has stopped responding to standard treatments. It compares the usual fixed schedule of 6 doses of Lu-PSMA therapy given every 6 weeks to a flexible schedule that allows up to 12 doses with planned breaks based …

This study tests a new radiation approach for adults with soft tissue sarcoma. Instead of weeks of daily radiation, patients receive higher doses over just 5 days before surgery. The goal is to see if this shorter course is safe, causes fewer long-term side effects like stiffness…

This study tests a treatment called radioembolization for early-stage kidney cancer. Tiny glass beads containing radioactive yttrium-90 are injected into the artery feeding the tumor to kill cancer cells from inside. The goal is to see if this approach is safe and effective for 2…

This study tests a new type of radiation therapy (PULSAR) combined with advanced planning technology (HyperArc) for people with head and neck cancer who cannot have or choose not to have standard treatment. The goal is to see if this approach can better control tumors while causi…

This study tests whether giving a second round of a radioactive drug called 177Lu-PSMA-617 can help men with advanced prostate cancer that stopped responding to hormone therapy and chemotherapy. The drug targets and delivers radiation directly to cancer cells. Only patients who h…

This study tests a new drug combination for people with a type of advanced lung cancer (non-small cell lung cancer) that has stopped responding to the standard treatment osimertinib. The experimental drug, telisotuzumab vedotin, is designed to find and kill cancer cells that have…

This study tests a drug called ivonescimab in 25 adults with thymic carcinoma, a rare cancer of the thymus gland. The drug helps the immune system attack cancer cells and may slow or shrink tumors. Participants must have already tried other treatments or be unable to take them.

This study tests whether the drug acalabrutinib, taken after cell therapy (like stem cell transplant or CAR T-cells), can help prevent relapse in patients with very high-risk large B-cell lymphoma. About 24 adults aged 18-70 will participate. The goal is to see if the drug is tol…

This study compares two radioactive drugs (225Ac-PSMA-617 and 177Lu-PSMA-617) given together with precise radiation therapy for prostate cancer that has returned and spread to a few spots in the body. About 107 adults with this type of cancer will receive one of the drugs plus ta…

This study tests the safety of dapagliflozin, a drug approved for diabetes and heart failure, when given before surgery to people with early-stage lung adenocarcinoma. The drug targets a protein found at high levels in these cancer cells. About 48 participants will receive the dr…

This early-phase study tests a type of internal radiation called brachytherapy for people with large kidney cancers (4-10 cm) that cannot be surgically removed or treated with standard ablation. The treatment places a temporary radiation source directly into the tumor to kill can…

This early-phase study tests whether a short course of radiation followed by chemotherapy can shrink tumors enough to avoid surgery in people with stage II-III rectal cancer. The goal is to preserve the rectum and improve quality of life. About 25 adults with locally advanced rec…

This study tests whether giving two drugs (pembrolizumab and enfortumab vedotin) before and after surgery to remove a kidney and ureter can improve outcomes for people with high-risk upper tract urothelial cancer. The drugs help the immune system attack cancer cells and deliver a…

This study is testing whether the immunotherapy drug pembrolizumab can help the body's immune system clear high-grade cervical precancer (CIN 2/3) without needing surgery. About 25 women with active, untreated precancer will receive the drug and be monitored for 6 months to see i…

This study tests the drug tarlatamab in people with advanced tumors that have a protein called DLL3. The goal is to see if the drug can shrink or control these tumors. About 29 adults with advanced DLL3-expressing cancers will receive tarlatamab and be monitored for response and …

This study tests whether adding two new drugs (zimberelimab and quemliclustat) to standard chemotherapy can help shrink pancreatic tumors that are either borderline removable or have spread locally. The goal is to make surgery possible and improve survival. About 56 adults with u…

This study tests whether a special PET/CT scan using flotufolastat F 18 can find leftover or returning prostate cancer after focal therapy. About 81 men who had focal treatment 6-36 months ago will get the scan. If it works, it could offer a less invasive way to check for cancer …

This study tests whether a special PET/CT scan using a radioactive tracer (flotufolastat F 18) can better guide prostate biopsies than standard MRI. About 30 men with suspicious MRI findings will get both types of scans before biopsy. The goal is to see if the new method finds mo…

This study is testing a new type of PET scan that uses a special sugar tracer (Me-4FDG) to find lung cancer earlier. The tracer is designed to highlight cancer cells that take up a lot of sugar. Researchers will check how safe and accurate this scan is in 60 adults who have a lun…

This study tests two advanced MRI techniques to better tell apart brain tumors that have come back from tissue damage caused by radiation therapy. About 42 adults with brain metastases will be scanned before surgery or radiation. The goal is to help doctors choose the right treat…

This study aims to find a less invasive way to diagnose thyroid cancer using blood samples instead of traditional needle biopsies. Researchers will analyze tiny particles called extracellular vesicles from the blood and tissue of 250 adults with thyroid nodules or cancer. The goa…

This study tests whether using community advocates can increase the number of people who get screened for breast and lung cancer. Researchers will enroll 800 eligible adults and track how many complete their recommended screenings. The goal is to understand psychological barriers…

This study compares two ways of giving stereotactic body radiation therapy (SBRT) for prostate cancer that hasn't spread. In standard SBRT, the radiation plan is fixed. In the new approach, doctors use daily MRI or CT scans to adjust the plan to match the patient's anatomy that d…

This study tests a new way to deliver radiation for prostate cancer that hasn't spread. By using real-time tracking to adjust the beam as the prostate moves, doctors hope to reduce urinary and bowel side effects. The study will enroll 80 men with early-stage prostate cancer to se…

This study tests a precise radiation technique for prostate cancer that aims to protect the nerves and blood vessels needed for erections. About 200 men will get either standard or this 'neurovascular-sparing' radiation. The goal is to see if the new method reduces sexual side ef…

This study compares virtual reality (VR) and music relaxation to standard care for reducing anxiety and pain in 600 women undergoing breast biopsies. Participants will be randomly assigned to one of three groups. The goal is to see if these simple, drug-free techniques make the p…

This study is testing whether an FDA-approved artificial intelligence (AI) tool can help radiologists find breast cancer more accurately when reading mammograms. About 400,000 adult women getting routine screening mammograms at six major U.S. health centers will be randomly assig…

This study looks at how endocrine therapy, a common breast cancer treatment, affects brain function and thinking skills in survivors. Researchers will compare 120 women aged 35-65 who are on this therapy with healthy women using brain scans and memory tests. The goal is to unders…

This study is testing a new combined MRI and PET scan to measure how brain tumors use energy. Researchers will compare scan results with tissue samples from 50 adults with glioblastoma who need surgery. The goal is to improve imaging, not to treat the disease directly.

This study looks at MRI scans and a protein called decorin in 50 patients with glioblastoma, a serious brain cancer. The goal is to find out which patients might benefit from a drug called bevacizumab. Researchers will compare imaging and tissue samples to better understand tumor…

This early-stage trial tests a new imaging method that uses a radioactive tracer to find immune cells (CD8+ T-cells) inside brain tumors. The goal is to see if this PET scan can show where immune cells are active without needing a biopsy. About 20 adults with brain tumors schedul…

This study tests three advanced MRI methods to look at the cells and proteins around glioblastoma brain tumors without needing surgery. Researchers want to understand why some tumors are harder to treat. About 15 adults with suspected glioblastoma will have these special scans be…

This study is testing whether growing a patient's tumor cells in the lab (called organoids) can help doctors predict which chemotherapy drugs will work best for that person. About 40 people with suspected or confirmed osteosarcoma will provide tumor samples during routine biopsie…

This early study tests a radioactive imaging agent called 99mTc-PSMA-I&S in 30 men with prostate cancer who are scheduled for lymph node removal surgery. The goal is to see how the agent spreads in the body and whether it can help surgeons detect cancer that has spread to lymph n…

This study looks at why some advanced prostate cancers become resistant to a treatment called 177Lu-PSMA. Researchers will take small tissue samples (biopsies) from tumors during treatment to find genetic changes that cause resistance. The goal is to learn how to make treatments …

This study tests a multi-level program to help patients with high-risk colon polyps get a follow-up colonoscopy within 3 years, as recommended. About 1,680 patients, along with their doctors and clinic staff, will take part. The program uses reminders and support to overcome barr…

This study tests a new clinic program to help more patients get a follow-up colonoscopy after an abnormal stool-based screening test (FIT). The program includes better coordination, standard referrals, and education for both patients and doctors. About 1,500 adults from six clini…

This study looks at blood and saliva samples from 2000 cancer patients to understand how inherited gene mutations influence cancer risk, tumor behavior, and response to treatment. Participants must have a confirmed cancer diagnosis and provide consent. The goal is to learn more a…