Jonsson Comprehensive Cancer Center

This phase 2 trial tests whether giving a radioactive drug (177Lu-PSMA) before precise radiation (SBRT) can better control prostate cancer that has come back in 1 to 5 spots. About 93 men with recurrent prostate cancer will receive either SBRT alone or the drug first, then SBRT. …

This phase III trial compares two types of image-guided radiation for prostate cancer: CT-guided and MRI-guided stereotactic body radiotherapy (SBRT). About 179 men with localized prostate cancer will receive the same radiation dose, but one group's treatment is guided by CT scan…

This study tests a combination of targeted drugs (ribociclib, tucatinib, trastuzumab, with or without fulvestrant) for HER2-positive breast cancer. In the first part, it looks at safety in patients whose cancer has spread. In the second part, it compares these drugs to standard c…

This study tests whether combining radiation therapy with immunotherapy drugs (durvalumab with or without tremelimumab) can help people with advanced bladder cancer who cannot or will not have chemotherapy. The trial includes 13 participants with cancer that has spread or cannot …

This early-phase study tests the safety of combining two immunotherapy drugs—nivolumab and BO-112—given before surgery for soft tissue sarcoma that can be removed. About 14 adults with certain sarcoma types will receive these drugs to see if they help the immune system fight the …

This study tests whether adding two antibody drugs (trastuzumab and necitumumab) to the standard pill osimertinib can shrink tumors in people with a specific type of advanced lung cancer (EGFR-mutated) that has stopped responding to osimertinib alone. About 30 participants will r…

This study tests whether a pea protein nutritional drink can reduce the need for feeding tubes in people with head and neck cancer undergoing chemoradiation. About 57 adults with locally advanced cancer will drink the supplement as a meal replacement. The goal is to see if it hel…

This trial is testing a new way to give radiation therapy for people with stage II-III non-small cell lung cancer that cannot be removed with surgery. Instead of standard daily radiation for many weeks, patients receive a shorter, higher-dose course (hypofractionated radiation) a…

This study tests a special type of radiation called stereotactic body radiotherapy (SBRT) for men with high-risk prostate cancer that hasn't spread. The treatment delivers a strong, focused dose of radiation to the tumor to kill cancer cells while sparing healthy tissue. Research…

This early-phase trial tests a personalized vaccine made from a patient's own white blood cells to treat a rare and aggressive brain tumor called H3 G34-mutant diffuse hemispheric glioma. The vaccine is designed to help the immune system recognize and kill tumor cells. Six adults…

This study tests a combination of three drugs—niraparib, temozolomide, and atezolizumab—in people with advanced solid tumors or extensive-stage small cell lung cancer. The goal is to find the best dose and see if the combination works better than atezolizumab alone as maintenance…

This phase 2 trial tests whether combining internal radiation (brachytherapy) with two immunotherapy drugs, durvalumab and tremelimumab, can help women with gynecologic cancers that are resistant to platinum chemotherapy. The study includes 9 participants with ovarian, endometria…

This phase II trial is testing whether combining antiandrogen drugs (leuprolide, apalutamide, abiraterone) with precise radiation (SBRT) can control prostate cancer that has come back and spread to a few other spots in the body. The study enrolls 28 men whose cancer has 1-5 visib…

This phase 2 trial tests a new approach for people with advanced cancers that have not responded to other treatments. Doctors take a patient's own white blood cells, genetically modify them to recognize a protein called NY-ESO-1 found on some cancer cells, and infuse them back af…

This early-phase trial tests whether adding the immunotherapy drug pembrolizumab to standard platinum-based chemotherapy can help people with rare, aggressive small cell or neuroendocrine cancers of the bladder or prostate. The study includes 15 participants whose cancer has spre…

This study tests a combination of two drugs, talazoparib and temozolomide, in 35 people with extensive-stage small cell lung cancer that came back after initial chemotherapy. Talazoparib blocks cancer cells from repairing their DNA, while temozolomide is a chemotherapy that kills…

This study looks at whether a special type of radiation called stereotactic body radiotherapy (SBRT) can help prevent prostate cancer from coming back after surgery. About 92 men who had their prostate removed and have signs of remaining cancer will receive SBRT. The goal is to s…

This early-phase trial is testing a new type of CAR-T cell therapy that targets two proteins (CD19 and CD20) on cancer cells. It is for people with certain B-cell lymphomas or chronic lymphocytic leukemia that have come back or not responded to standard treatments. The therapy in…

This study tests whether a special PET/CT scan (68Ga-PSMA-11) can help doctors plan more precise radiation for men whose prostate cancer has come back after surgery. About 193 men with a rising PSA level will be randomly assigned to have their radiation plan based on either the n…

This study tests whether a special type of scan called SPECT/CT can help doctors make better decisions about treating kidney tumors. The scan uses a radioactive tracer to see how tumors behave. Researchers will check if the scan changes what doctors recommend for 102 patients wit…

This study tests whether a special PET scan (68Ga-PSMA-11) can help guide prostate biopsies to find aggressive prostate cancer in men who had a previous negative or unclear biopsy. About 30 men with suspected cancer will receive the scan, and if it shows a suspicious spot, that a…

This early study tests a new radioactive tracer called 68Ga-FAPI-46, which targets a protein (FAP) found around many tumors. About 26 people with various cancers will get a PET/CT scan using this tracer to see where it goes in the body. The goal is to learn if this tracer can hel…

This study compares two genetic tests, Afirma GSC and ThyroSeq v.3, on tissue from thyroid nodules that have unclear biopsy results. The goal is to see which test better identifies benign nodules, so patients can avoid unnecessary surgery. About 328 participants with indeterminat…

This study is testing a new type of MRI scan that looks at sodium and other chemicals in the brain to get a clearer picture of brain tumors (gliomas). The goal is to improve how doctors detect, diagnose, and track these tumors. The study includes healthy volunteers and people wit…

This study tests a culturally tailored program to increase colorectal cancer screening among low-income and ethnic minority groups, who are disproportionately affected by the disease. Nearly 10,000 patients aged 50-75 will receive education, consultations, and fecal immunochemica…

This study looks at whether screening for malnutrition and providing weekly nutritional support can improve quality of life for people with pancreatic cancer that cannot be removed by surgery. About 100 adults with this type of cancer are taking part. The goal is to see if better…

This phase II trial tests whether Soylent, a liquid meal replacement, can help head and neck cancer patients avoid needing a feeding tube during chemoradiotherapy. About 60 patients with locally advanced cancer will drink Soylent alongside their treatment. The goal is to see if t…

This study looks at whether Tai Chi, a gentle moving meditation, can improve chronic insomnia in breast cancer survivors. About 90 women who have completed cancer treatment and have had trouble sleeping for at least 6 months will practice Tai Chi. Researchers will measure sleep q…

This study is a registry that tracks side effects and outcomes in people who have undergone cryoablation (freezing) for early stage breast cancer. It is not testing a new treatment but rather collecting real-world data on symptoms, complications, and follow-up results. Only 2 par…

This study tests whether a video-based educational program can help people who have had uveal melanoma (a rare eye cancer) better understand their disease and feel more in control. About 108 adults who completed treatment are randomly assigned to watch the video or receive usual …

This study explores whether a genetic test can identify prostate cancer patients at higher risk for urinary side effects from radiation therapy. Researchers will track side effects in 208 men with early-stage prostate cancer who receive stereotactic radiation. The goal is to see …