Jonsson Comprehensive Cancer Center

This early-stage trial tests a custom-made vaccine for a rare and aggressive brain cancer called H3 G34-mutant diffuse hemispheric glioma. The vaccine is created from the patient's own white blood cells and designed to help the immune system recognize and attack tumor cells. The …

This early-phase study tests whether adding an experimental drug (BO-112) to the immunotherapy nivolumab before surgery can help treat soft tissue sarcoma. About 14 adults with removable tumors will receive the combination to check for side effects and immune changes. The goal is…

This study tests a new approach for people with advanced cancers that have not responded to standard treatments. Researchers take a patient's own white blood cells, genetically modify them to recognize a protein called NY-ESO-1 found on cancer cells, and return them to the body a…

This study tests a special type of radiation called stereotactic body radiotherapy (SBRT) in men who have had their prostate removed but show signs of cancer returning (rising PSA). The goal is to see if SBRT can control the cancer and delay or avoid further treatments. About 92 …

This study tests whether a combination of two drugs, talazoparib and temozolomide, can shrink tumors in people with advanced small cell lung cancer that has come back after initial treatment. The trial includes 35 adults whose cancer has progressed within 6 months of first-line c…

This study tests a combination of targeted drugs (ribociclib, tucatinib, trastuzumab) for HER2-positive breast cancer that has spread or is in early stages. The goal is to see if these drugs are safe and can shrink tumors before surgery better than standard chemotherapy. About 18…

This early-phase trial studies whether adding the immunotherapy drug pembrolizumab to standard chemotherapy can help people with rare, aggressive small cell or neuroendocrine cancers of the bladder or prostate. About 15 participants with cancer that has spread will receive the co…

This study tested a new way of giving radiation therapy (called image-guided hypofractionated radiotherapy with a stereotactic boost) along with standard chemotherapy for people with stage II-III non-small cell lung cancer that cannot be removed by surgery. The goal was to find t…

This study tests a special type of radiation called stereotactic body radiotherapy (SBRT) for men with high-risk prostate cancer that has not spread. SBRT delivers a very focused, high dose of radiation directly to the tumor, aiming to kill cancer cells while sparing normal tissu…

This study tests whether combining radiation therapy with two immunotherapy drugs (durvalumab with or without tremelimumab) can help control advanced bladder cancer in people who cannot or will not have chemotherapy. About 13 participants with cancer that has spread or can't be s…

This early-phase trial is testing a new type of immunotherapy for people with certain blood cancers (like lymphoma and leukemia) that have returned or stopped responding to standard treatments. The therapy uses a patient's own immune cells, which are modified in a lab to recogniz…

This study is for people with advanced gynecologic cancers (ovarian, endometrial, or cervical) that no longer respond to standard platinum chemotherapy. It combines internal radiation (brachytherapy) with two immunotherapy drugs, durvalumab and tremelimumab, to boost the immune s…

This study tests whether adding two antibody drugs (necitumumab and trastuzumab) to the standard pill osimertinib can shrink tumors in people with advanced EGFR-mutated lung cancer that has stopped responding to osimertinib alone. About 30 adults with stage IV non-small cell lung…

This study tests a combination of three drugs (niraparib, temozolomide, and atezolizumab) in people with advanced solid tumors or extensive-stage small cell lung cancer. The goal is to find the safest dose and see if the combination helps keep the cancer from growing longer than …

This study is testing a two-part treatment for men whose prostate cancer has returned and spread to a few other places in the body. The treatment combines hormone-blocking drugs with very precise, high-dose radiation aimed directly at the cancer spots. The goal is to see if this …

This study compares two genetic tests (Afirma and ThyroSeq) for thyroid nodules that have unclear biopsy results. The goal is to see which test more accurately identifies benign nodules, so patients can avoid unnecessary surgery and maintain quality of life. About 328 adults with…

This study explores whether a PET scan using a special tracer (68Ga-PSMA-11) can help guide prostate biopsies to find serious prostate cancer more accurately. It involves 30 men who had a previous biopsy that was negative or unclear. The goal is to improve detection and reduce bo…

This study tests a new type of MRI scan that looks at sodium and other signals in the brain to better understand tumors. It includes healthy volunteers and people with brain tumors (glioma). The goal is to improve how doctors detect and monitor these tumors, which could lead to b…

This study looks at whether a special type of scan called SPECT/CT can help doctors choose the best treatment for people with kidney tumors. About 100 participants with small to medium-sized kidney tumors will get this scan. The goal is to see if the scan changes what doctors rec…

This study looks at whether Tai Chi, a gentle moving meditation, can improve chronic insomnia in breast cancer survivors. About 90 women who have finished cancer treatment and have had trouble sleeping for at least 6 months will practice Tai Chi or receive another treatment. Rese…

This study compares two types of image-guided radiation therapy for prostate cancer: one using CT scans and the other using MRI scans. The goal is to see if MRI guidance reduces short-term urinary and bowel side effects. About 179 men with localized prostate cancer are participat…

This study tests whether a plant-based pea protein drink can reduce the need for feeding tubes in people with head and neck cancer undergoing chemoradiation. Feeding tubes can cause long-term swallowing problems. The drink is designed to be easy to digest and free of common aller…

This study tests whether a liquid meal replacement called Soylent can help people with head and neck cancer avoid needing a feeding tube while they undergo chemotherapy and radiation. About 60 patients will drink Soylent regularly during treatment. The goal is to see if it keeps …

This early-phase study tests a new imaging agent called 68Ga-FAPI-46, which targets cells around tumors. About 26 adults with various cancers will receive the tracer and then have a PET/CT scan. The goal is to see where the tracer goes in the body and compare it to standard imagi…

This study looks at how to get more people from low-income and ethnic minority groups screened for colorectal cancer. Colorectal cancer is a leading cause of cancer death, and these groups are often missed. The main tool is a simple at-home test (FIT) that checks for blood in the…

This study looks at whether a DNA-based biomarker can help predict long-term urinary side effects from radiation therapy in men with prostate cancer. About 208 patients will have their DNA tested and both they and their doctors will see the results. The goal is to see if knowing …

This study is a registry that follows people who have had cryoablation (freezing treatment) for early-stage breast cancer. Researchers will track side effects, symptoms, and any future cancer-related events to better understand how well this treatment works. Only 2 participants a…

This study tests a video-based program designed to help people who have had uveal melanoma, a rare eye cancer, understand their illness and feel more in control. Researchers want to see if the program changes how survivors think about their disease and improves their mental healt…