Experimental combo aims to boost immune attack on sarcoma before surgery

NCT ID NCT04420975

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase study tests the safety of combining two immunotherapy drugs—nivolumab and BO-112—given before surgery for soft tissue sarcoma that can be removed. About 14 adults with certain sarcoma types will receive these drugs to see if they help the immune system fight the tumor more effectively. The main goal is to check for side effects and measure immune changes in the tumor tissue after treatment.

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Conditions

The condition(s) this trial relates to.

dedifferentiated liposarcoma dermatofibrosarcoma protuberans fibrosarcoma leiomyosarcoma malignant giant cell tumor of soft parts malignant peripheral nerve sheath tumor myxofibrosarcoma neurofibrosarcoma pleomorphic rhabdomyosarcoma retroperitoneal sarcoma sarcoma soft tissue sarcoma spindle cell sarcoma synovial sarcoma undifferentiated high grade pleomorphic sarcoma of bone undifferentiated pleomorphic sarcoma undifferentiated pleomorphic sarcoma, inflammatory variant

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • UCLA / Jonsson Comprehensive Cancer Center

    Los Angeles, California, 90095, United States