New imaging agent aims to light up hidden tumors

NCT ID NCT07664397

Not yet recruiting Diagnosis Sponsor: Robert Flavell, MD, PhD Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage study will test a new radioactive tracer called [89Zr]DFO-YS5 in 40 people with nerve sheath tumors, bladder cancer, or other advanced solid tumors. The tracer is designed to bind to cancer cells and show up on PET scans, potentially making tumors easier to see. The main goal is to measure how well the tracer highlights tumors compared to normal tissue, and to check for any side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: [89Zr]DFO-YS5 (a radioactive tracer injected intravenously)
What this could lead to: If successful, this could improve how doctors see and locate certain cancers on PET scans, potentially aiding diagnosis.
What could go wrong: This is a very early (Phase 1) pilot study with only 40 people. It is designed to test imaging, not treatment, so it may not lead to any direct benefit for patients.

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Conditions

The condition(s) this trial relates to.

cancer carcinoma hypertrophic pyloric stenosis malignant peripheral nerve sheath tumor neoplasm nerve sheath neoplasm peripheral nervous system neoplasm urinary bladder carcinoma urinary bladder neoplasm Urinary Bladder Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED SOLID TUMOR BLADDER CANCER BLADDER NEOPLASM NERVE SHEATH NEOPLASMS NERVE SHEATH TUMOR NERVE SHEATH TUMOR, NOS NERVE SHEATH TUMORS SOLID CARCINOMA SOLID TUMOR CANCER SOLID TUMOR MALIGNANCIES SOLID TUMOR NEOPLASMS SOLID TUMOR, ADULT

Contacts and locations

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Locations

University of California, San Francisco

San Francisco, California, 94143, United States

Contact Email: •••••@•••••

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