SOLID TUMOR CANCER

This study tests a personalized vaccine made from a patient's own immune cells (dendritic cells) that are trained to attack unique markers on their tumor. It is for people aged 18-75 with advanced solid tumors who have not responded to standard treatments. The goal is to see if t…

This study tests a new combination of two drugs (HLX43 and Serplulimab) in people with advanced solid tumors, including lung cancer. The goal is to find the safest dose and see if the treatment can shrink tumors. About 105 adults who have not responded to other treatments will ta…

This study tests a new drug called AVZO-103 in people with advanced bladder cancer or other solid tumors that have spread. The drug is designed to attack cancer cells directly. The main goals are to find a safe dose and see if it shrinks tumors. About 355 adults will take part.

This study tests two drugs, IN10018 and RNK08954, together in people with advanced solid tumors that have a specific genetic change called KRAS G12D. The goal is to find the best dose and see if the combination can shrink tumors. About 92 adults with locally advanced or metastati…

This early-phase study is testing an experimental drug called WTX212A, given alone or with radiation therapy, in 12 people with advanced solid tumors. The goal is to see if the drug is safe and can shrink or control tumors. Participants must be 18-75 years old and have a confirme…

This study tests a new drug called AVZO-1418 in people with advanced solid tumors that have spread. The goal is to find a safe dose and see if it shrinks tumors. About 430 adults will take part. The drug is given through a vein, alone or with other treatments.

This early-phase trial is testing a new treatment called TC-G203 for people with advanced solid tumors that have a specific marker (GPC3) and have not responded to standard therapies. The main goal is to find the safest dose and check for side effects. About 30 adults will take p…

This study is for children and teens (ages 3–18) whose solid tumors have come back or not responded to standard treatment. The therapy combines a radioactive drug (Lutathera) that targets specific receptors on tumor cells with a pill (olaparib) that may make the radiation more ef…

This study tests an experimental drug called GV20-0251 in adults with advanced solid tumors (like lung, head and neck, or colon cancer) that have stopped responding to standard therapies. The goal is to see if the drug can shrink tumors or slow their growth. About 350 participant…

This early-phase trial tests an investigational drug called SYS6043 in adults with advanced or metastatic solid tumors that have spread or no longer respond to standard treatments. The main goals are to find a safe dose, understand side effects, and see if the drug can slow tumor…

This early-phase study tests the safety and best dose of a new drug called PLT012 in adults with advanced solid tumors that have not responded to other treatments. About 36 participants will receive the drug by IV every three weeks. The study will monitor side effects, drug level…

This study tests whether eating all meals within an 8-hour window each day can improve how well cancer treatments work and reduce side effects. Researchers will enroll 100 Alaska Native and American Indian adults with rectal or breast cancer. Participants will follow this eating …

This study tests whether a mobile app that tracks symptoms and sensor data can help people receiving chemotherapy feel better and stay connected with their care team. About 50 adults with solid tumors will use the app and a Fitbit for 90 days. The goal is to see if the app is eas…

This study looks at how chemical changes to DNA, called methylation, differ in brain, thyroid, and endometrial cancers. By analyzing tumor samples from 180 people, researchers hope to create better ways to classify these cancers and find new targets for diagnosis. The goal is to …

This study will test a program that screens cancer patients for emotional distress and refers them to mental health services. It involves 50 English- or Spanish-speaking adults with a new solid tumor diagnosis at Jamaica Hospital Medical Center. The goal is to see if the program …

This study enrolls 35 people with advanced cancers that no longer respond to standard treatments. Doctors take a small sample of the tumor, grow it in the lab, and test many drugs on it to see which ones kill the cancer cells. The goal is to see if this lab test can reliably pick…

This study is testing whether a blood test that looks for tumor DNA (ctDNA) can find cancer returning sooner than standard scans. Researchers will follow 100 people with various solid tumors to see if early detection leads to better treatment options. The goal is to improve how w…