New drug duo targets tough KRAS mutation in advanced cancers
NCT ID NCT07441174
First seen Mar 12, 2026 · Last updated Apr 29, 2026 · Updated 6 times
Summary
This study tests two experimental drugs, IN10018 and RNK08954, given together to people with advanced solid tumors that have a specific KRAS G12D gene change. The goal is to find the best dose and see if the combination can shrink tumors. About 92 adults with locally advanced or metastatic cancer will take part.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Affiliated Drum Tower Hospital, Medical School of Nanjing University
NOT_YET_RECRUITINGNanjing, Jiangsu, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Cancer Hospital Chinese Academy of Medical Sciences
NOT_YET_RECRUITINGBeijing, Beijing Municipality, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Fujian Cancer Hospital
NOT_YET_RECRUITINGFuzhou, Fujian, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hunan Cancer Hospital
NOT_YET_RECRUITINGChangsha, Hunan, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Jiangsu Province Hospital
NOT_YET_RECRUITINGNanjing, Jiangsu, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
NOT_YET_RECRUITINGShanghai, Shanghai Municipality, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Shandong Cancer Hospital
NOT_YET_RECRUITINGJinan, Shandong, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Sun Yat-sen Memorial Hospital, Sun Yat-sen University
NOT_YET_RECRUITINGGuangzhou, Guangdong, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The First Affiliated Hospital of China Medical University
NOT_YET_RECRUITINGShengyang, Liaoning, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The First Affiliated Hospital of Henan University of Science and Technology
NOT_YET_RECRUITINGLuoyang, He, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The First Affiliated Hospital of Wenzhou Medical University
NOT_YET_RECRUITINGWenzhou, Zhejiang, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The First Affiliated Hospital of Xi'an Jiaotong University
NOT_YET_RECRUITINGXi’an, Shanxi, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The First Affiliated Hospital of Zhengzhou University
NOT_YET_RECRUITINGZhengzhou, Henan, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310005
RECRUITINGHangzhou, Zhejiang, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Conditions
Explore the condition pages connected to this study.