New smart drug takes aim at Hard-to-Treat cancers

NCT ID NCT07193511

Recruiting now Disease control Sponsor: Avenzo Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Aug 06, 2026 · Updated 5 times

Summary

This study tests a new drug called AVZO-103 in people with advanced bladder cancer or other solid tumors that have spread. The drug is designed to seek out and attack cancer cells while sparing healthy ones. The trial will enroll about 355 adults and is the first time this drug is being tested in humans, focusing on safety and whether it can shrink tumors.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: AVZO-103 (a drug that targets two proteins on cancer cells, Nectin4 and Trop2, to deliver a toxin directly to the tumor)
What this could lead to: If successful, this could provide a new treatment option for people with advanced bladder cancer or other solid tumors that have stopped responding to standard therapies.
What could go wrong: This is a very early first-in-human study, so the drug may not be safe or effective. Side effects could be serious, and the benefits seen in a small group may not hold up in larger trials.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cancer metastatic malignant neoplasm Neoplasm Metastasis urothelial carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LOCALLY ADVANCED METASTATIC SOLID TUMORS SOLID TUMOR CANCER UROTHELIAL CANCER

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Avenzo Therapeutics Recruiting Site
RECRUITING

San Francisco, California, 94158, United States
Avenzo Therapeutics Recruiting Site
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Aurora, Colorado, 80045, United States
Avenzo Therapeutics Recruiting Site
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New Haven, Connecticut, 06519, United States
Avenzo Therapeutics Recruiting Site
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Orlando, Florida, 32827, United States
Avenzo Therapeutics Recruiting Site
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Tampa, Florida, 33612, United States
Avenzo Therapeutics Recruiting Site
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Boston, Massachusetts, 02114, United States
Avenzo Therapeutics Recruiting Site
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New York, New York, 10065, United States
Avenzo Therapeutics Recruiting Site
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Chapel Hill, North Carolina, 27514, United States
Avenzo Therapeutics Recruiting Site
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Cleveland, Ohio, 44106, United States
Avenzo Therapeutics Recruiting Site
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Myrtle Beach, South Carolina, 29572, United States
Avenzo Therapeutics Recruiting Site
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Nashville, Tennessee, 37203, United States
Avenzo Therapeutics Recruiting Site
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Austin, Texas, 78758, United States
Avenzo Therapeutics Recruiting Site
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Irving, Texas, 75039, United States

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