UROTHELIAL CANCER

This early-stage study is testing the safety of a new two-drug immunotherapy combination, with or without a precise form of radiation, for adults with advanced urinary tract cancers that have spread. The goal is to see if these treatments can work together to help the body's own …

This is a first-in-human study to test the safety and early signs of effectiveness of a new drug called STRO-004 in adults with advanced solid tumors that have come back or stopped responding to other treatments. The trial will test STRO-004 alone and in combination with an exist…

This trial is testing whether a new drug combination called izalontamab brengitecan works better than standard chemotherapy for people with advanced bladder cancer that has stopped responding to immunotherapy. About 470 participants will receive either the experimental drug or ch…

This study is testing new combinations of cancer drugs for people with advanced bladder cancer that has spread. The first part aims to find the safest doses of two drugs. The second part will test how well these two drugs work together, and also test a three-drug combination, to …

This is the first-ever study in people for a new experimental drug called AVZO-103. It aims to find a safe and effective dose for adults with advanced cancers that have spread, including bladder cancer. The study will test the drug alone and in combination with other therapies to…

This is the first human study of an experimental drug called SLV-154 for people with advanced solid tumors that have spread. The main goal is to find the highest safe dose and understand how the body processes the drug. About 70 adults with one of ten specific advanced cancers wh…

This study is for people with advanced bladder cancer that has continued to grow despite receiving a specific prior combination treatment. It will compare a new drug combination (datopotamab deruxtecan plus a platinum chemotherapy) against a standard chemotherapy combination. The…

This study is testing whether analyzing DNA and proteins in urine can help detect cancers of the bladder and kidney. Researchers will compare this new, non-invasive method to current standard procedures like cystoscopy. The goal is to develop a simpler, more comfortable way to fi…

This study aims to collect real-world information on the safety and effectiveness of PADCEV, a treatment for advanced bladder cancer. It will follow about 200 adult patients in South Korea who are already prescribed this drug by their doctors as part of their standard care. Resea…

This study aims to collect blood, urine, saliva, and tissue samples from people with bladder or urinary tract cancer, as well as from healthy volunteers. Researchers will compare these samples to learn what genetic and cellular changes cause this cancer to develop. The goal is to…

This study aims to understand the course of rare cancers in the urinary system (like bladder, kidney, and prostate cancers) by tracking patients over time. Researchers will collect medical information, blood, urine, and sometimes tumor samples from about 1,100 adults with these c…

This study aims to understand how often and how severely nerve damage occurs in bladder cancer patients receiving a specific two-drug treatment. Researchers will follow 80 patients receiving enfortumab vedotin and pembrolizumab to track this side effect, its impact on daily life,…