New drug cocktail takes on seven tough cancers

NCT ID NCT05489211

Recruiting now Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 trial is testing a drug called datopotamab deruxtecan (Dato-DXd), alone or with other cancer medicines, in people with advanced or metastatic solid tumours. The study includes seven cancer types and aims to see if the drug shrinks tumours and how safe it is. Around 454 participants will be enrolled at multiple centres.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

datopotamab deruxtecan (Dato-DXd), a targeted chemotherapy drug

What this could lead to

If successful, this could offer a new treatment option for several advanced cancers that are hard to treat.

What could go wrong

This is an early-phase trial with many different cancer types, so results may not apply to all. Side effects from the drug combinations could be serious.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

biliary tract cancer Biliary Tract Neoplasms castration-resistant prostate carcinoma colorectal cancer colorectal neoplasm endometrial cancer endometrium neoplasm gastric cancer gastric neoplasm metastatic prostate carcinoma ovarian cancer urothelial carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BILIARY TRACT CANCER COLORECTAL CANCER ENDOMETRIAL CANCER GASTRIC CANCER METASTATIC CASTRATION-RESISTANT PROSTATE CANCER OVARIAN CANCER UROTHELIAL CANCER

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Research Site
RECRUITING

Los Angeles, California, 90095, United States
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WITHDRAWN

San Diego, California, 92103, United States
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Santa Rosa, California, 95403, United States
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Muncie, Indiana, 47303, United States
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Kansas City, Kansas, 66160, United States
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WITHDRAWN

Boston, Massachusetts, 02114, United States
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COMPLETED

Boston, Massachusetts, 02215, United States
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RECRUITING

Grand Rapids, Michigan, 49503, United States
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East Brunswick, New Jersey, 08816, United States
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Albuquerque, New Mexico, 87109, United States
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Commack, New York, 11725, United States
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Cincinnati, Ohio, 45219, United States
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Columbus, Ohio, 43219, United States
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Portland, Oregon, 97239, United States
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RECRUITING

Nashville, Tennessee, 37203, United States
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Nashville, Tennessee, 37232, United States
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Houston, Texas, 77030, United States
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RECRUITING

Madison, Wisconsin, 53792, United States
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Toronto, Ontario, M4N 3M5, Canada
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COMPLETED

Toronto, Ontario, M5G 2M9, Canada
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WITHDRAWN

Montreal, Quebec, H2X 0A9, Canada
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COMPLETED

Montreal, Quebec, H4A 3J1, Canada
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ACTIVE_NOT_RECRUITING

Québec, Quebec, G1J 1Z4, Canada
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WITHDRAWN

Changsha, 410013, China
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WITHDRAWN

Chongqing, 400030, China
Research Site
COMPLETED

Guangzhou, 510060, China
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RECRUITING

Guangzhou, 510060, China
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Guangzhou, 510120, China
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Hangzhou, 310020, China
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WITHDRAWN

Hefei, 230001, China
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RECRUITING

Shanghai, 200032, China
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NOT_YET_RECRUITING

Shanghai, 200032, China
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Shenyang, 110016, China
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Wuhan, 430030, China
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Wuhan, 430079, China
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WITHDRAWN

Xi'an, 710000, China
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RECRUITING

Zhengzhou, 450052, China
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Bordeaux, 33076, France
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Lyon, 69373, France
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Marseille, 13273, France
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Suresnes, 92150, France
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WITHDRAWN

Berlin, 10117, Germany
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Essen, 45136, Germany
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Hanover, 30625, Germany
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München, 81377, Germany
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Regensburg, 93053, Germany
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Florence, 50139, Italy
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Genova, 16132, Italy
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RECRUITING

Milan, 20132, Italy
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Milan, 20141, Italy
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RECRUITING

Milan, 20162, Italy
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Naples, 80131, Italy
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Rome, 00168, Italy
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Chūōku, 104-0045, Japan
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Kashiwa, 277-8577, Japan
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Kōtoku, 135-8550, Japan
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Nagoya, 464-8681, Japan
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Shinagawa-ku, 142-8666, Japan
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Suita-shi, 565-0871, Japan
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Gliwice, 44-102, Poland
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Krakow, 31-501, Poland
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WITHDRAWN

Lodz, 92-213, Poland
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WITHDRAWN

Poznan, 61-866, Poland
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COMPLETED

Warsaw, 02-781, Poland
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RECRUITING

Seoul, 03722, South Korea
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Seoul, 05505, South Korea
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RECRUITING

Seoul, 06351, South Korea
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Seoul, 110-744, South Korea
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Barcelona, 8035, Spain
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TERMINATED

Córdoba, 14004, Spain
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RECRUITING

Madrid, 28046, Spain
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RECRUITING

Málaga, 29010, Spain
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RECRUITING

Pamplona, 31008, Spain
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Seville, 41013, Spain
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WITHDRAWN

Basel, 4031, Switzerland
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Bellinzona, 6500, Switzerland
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WITHDRAWN

Sankt Gallen, 9007, Switzerland
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Liou Ying Township, 736, Taiwan
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Taipei, 100, Taiwan
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RECRUITING

Taipei, 11259, Taiwan
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Taipei, 112, Taiwan
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Taoyuan, 333, Taiwan
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RECRUITING

Ankara, 06620, Turkey (Türkiye)
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Ankara, 06800, Turkey (Türkiye)
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RECRUITING

Cordaleo, 35575, Turkey (Türkiye)
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Edirne, 22030, Turkey (Türkiye)
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RECRUITING

Kadıkoy/Istanbul, 34722, Turkey (Türkiye)
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Konya, 42080, Turkey (Türkiye)
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RECRUITING

Pamukkale, 20070, Turkey (Türkiye)
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WITHDRAWN

Samsun, 55139, Turkey (Türkiye)
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RECRUITING

Cambridge, CB2 0QQ, United Kingdom
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RECRUITING

Dundee, DD1 9SY, United Kingdom
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London, EC1A 7BE, United Kingdom
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RECRUITING

London, NW1 2PG, United Kingdom
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RECRUITING

London, SE1 9RT, United Kingdom
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RECRUITING

Manchester, M20 4BX, United Kingdom