New drug combo aims to tackle Hard-to-Treat HER2 cancers
NCT ID NCT07646626
First seen Jun 26, 2026 · Last updated Jul 29, 2026 · Updated 3 times
Summary
This Phase 2 trial is testing two experimental drugs (SSGJ-705 and SSGJ-612) with or without chemotherapy in 150 adults with advanced HER2-positive solid tumors, including colorectal, bladder, breast, bile duct, and stomach cancers. The goal is to see if the combination can shrink tumors and control the disease longer than current options. Participants must have tumors that cannot be removed by surgery or have spread.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- SSGJ-705 (a bispecific antibody targeting PD-1 and HER2) and SSGJ-612 (an anti-HER2 antibody), with or without chemotherapy
- What this could lead to
- If successful, this combination could offer a new treatment option for people with advanced HER2-positive cancers that have stopped responding to standard therapies.
- What could go wrong
- This is a mid-stage (Phase 2) trial with only 150 participants, so results may not apply to everyone. The drugs may cause side effects or fail to shrink tumors in many patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Zhejiang Cancer Hospital
RECRUITINGHangzhou, Zhejiang, China
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