New drug combo may help bladder cancer patients keep their bladder

NCT ID NCT07566156

Recruiting now Disease control Sponsor: Astellas Pharma Global Development, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 3 times

Summary

This study tests whether two drugs, enfortumab vedotin and pembrolizumab, can control muscle-invasive bladder cancer without needing to remove the bladder. About 390 adults whose cancer hasn't spread outside the bladder will receive either the drug combo or standard chemoradiation. The goal is to see if the combo helps patients live longer and keeps the bladder cancer-free.

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Conditions

The condition(s) this trial relates to.

benign urinary system neoplasm Female Urogenital Diseases infiltrating bladder urothelial carcinoma Male Urogenital Diseases neoplasm Neoplasms by Site transitional cell carcinoma urinary bladder disorder urinary bladder neoplasm Urinary Bladder Neoplasms urinary system disorder Urogenital Diseases Urogenital Neoplasms urothelial carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

URINARY BLADDER NEOPLASMS UROTHELIAL CANCER

Contacts and locations

Locations

Compass Oncology - West
RECRUITING

Tigard, Oregon, 97223, United States
Fort Wayne Medical Oncology and Hematology
RECRUITING

Fort Wayne, Indiana, 46825, United States
Illinois Cancer Specialists
RECRUITING

Niles, Illinois, 60714, United States
Medical Oncology Hematology Consultants
RECRUITING

Newark, Delaware, 19713, United States
Missouri Cancer Associates
RECRUITING

Columbia, Missouri, 65201, United States
Rocky Mountain Cancer Center
RECRUITING

Aurora, Colorado, 80012, United States
SCRI Oncology Partners
RECRUITING

Nashville, Tennessee, 37203, United States
Samsun Clinic - Ridley-Tree Cancer Center
RECRUITING

Santa Barbara, California, 93105, United States
Texas Oncology
RECRUITING

Austin, Texas, 78705, United States
Texas Oncology - Northeast Texas
RECRUITING

Tyler, Texas, 75702, United States
Virginia Oncology Associates
RECRUITING

Norfolk, Virginia, 23502, United States
Williamette Valley Cancer Institute and Research Center
RECRUITING

Eugene, Oregon, 97401, United States

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