Bladder cancer: a new combo aims to avoid radical surgery
NCT ID NCT07756008
First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time
Summary
This trial tests whether combining two drugs—disitamab vedotin and toripalimab—with or without pelvic lymph node removal can help people with muscle-invasive bladder cancer keep their bladder. Participants, who have HER2-positive tumors and decline bladder removal surgery, will receive a procedure to remove the tumor followed by the drug combo. The study compares outcomes between those who also have lymph nodes removed and those who don't, focusing on survival without bladder cancer returning.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- disitamab vedotin (an antibody-drug conjugate) combined with toripalimab (an immunotherapy drug), plus a procedure to remove bladder tumors and, in some patients, pelvic lymph nodes
- What this could lead to
- If successful, this approach could offer a way to treat muscle-invasive bladder cancer without removing the bladder, potentially preserving quality of life while controlling the disease.
- What could go wrong
- This is an early-phase trial, so the combination may not work as hoped or could cause significant side effects. The benefit of adding lymph node removal is uncertain and may not improve outcomes.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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The Second Hospital of Tianjin Medical University
Tianjin, Tianjin Municipality, 300211, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a Bag-Like device pull bladder tumors out whole?
- Can Pre-Surgery chemotherapy outsmart aggressive bladder cancer?
- Can a special PET scan see bladder cancer more clearly?
- Could a simple urine test spare bladder cancer patients from chemotherapy?
- Can a new drug rally the immune system against Hard-to-Treat cancers?
- Can One-Piece tumour removal improve bladder cancer outcomes?