Urinary bladder disorder

This early-stage trial tests a personalized cancer vaccine for people with bladder or stomach cancer who still have tiny amounts of cancer DNA in their blood after surgery. The vaccine is made from unique proteins in each person's tumor and aims to train the immune system to find…

This study tests whether adding an experimental treatment (V940) to standard BCG therapy helps people with high-risk non-muscle invasive bladder cancer live longer without their cancer returning. About 308 adults will be randomly assigned to get either V940 plus BCG or BCG alone.…

This early-stage trial is testing an experimental drug called EVOLVE104 in people with advanced bladder cancer or several types of squamous cell carcinoma (lung, esophagus, skin, and others). The study aims to find a safe dose and see if the drug can shrink tumors. It is for pati…

This study is for people with advanced bladder cancer that has gotten worse after standard treatment. It tests a new drug combination (datopotamab deruxtecan plus chemotherapy) against another chemotherapy combo. The goal is to see if the new combo can shrink tumors or slow the c…

This phase 3 trial tests whether the experimental drug sacituzumab tirumotecan helps people with advanced bladder cancer live longer than standard chemotherapy. About 590 participants whose cancer worsened after prior treatments will receive either the new drug or one of several …

This phase II trial is testing whether a combination of three drugs—cabozantinib, nivolumab, and ipilimumab—can shrink or slow the growth of rare genitourinary cancers that have spread. About 314 adults with these uncommon tumors will receive the drugs. The goal is to see if the …

This study tests whether two drugs, enfortumab vedotin and pembrolizumab, can control muscle-invasive bladder cancer without needing to remove the bladder. About 390 adults whose cancer hasn't spread outside the bladder will receive either the drug combo or standard chemoradiatio…

This phase 2 trial tests whether the drug sacituzumab govitecan, alone or combined with atezolizumab, can shrink rare tumors of the kidney, bladder, ureters, or penis. About 60 adults with specific rare cancer types will receive the drugs intravenously in 21-day cycles. The study…

This phase 3 trial tests whether adding the chemotherapy drug gemcitabine to standard BCG therapy can better prevent high-grade bladder cancer from coming back. About 330 people with recurrent non-muscle invasive bladder cancer will receive either BCG alone or BCG plus gemcitabin…

This large trial is testing whether a blood test that looks for tumor DNA can help decide who needs immunotherapy after surgery for muscle-invasive urothelial cancer. About 992 participants will be assigned to different treatment plans based on their blood test results. The goal …

This phase 2 trial tests whether a combination of enfortumab vedotin and pembrolizumab can help people with muscle-invasive bladder cancer avoid bladder removal. About 240 adults who are candidates for surgery will receive the drugs intravenously. The main goals are to see how ma…

This early-phase trial is testing whether adding an experimental drug called emavusertib (CA-4948) to the immunotherapy pembrolizumab can help patients with advanced urothelial cancer whose tumors have become resistant to PD-1/PD-L1 blockers. The study will enroll 27 adults and f…

This phase 3 trial tests a gene therapy called nadofaragene firadenovec against simply watching and waiting in people with intermediate-risk non-muscle invasive bladder cancer. The study will enroll 454 participants who have had a tumor removed. The goal is to see if the gene the…

This expanded access program provides vepugratinib, an oral drug, to people with metastatic urothelial carcinoma or other solid tumors that have a specific FGFR3 genetic change. Participants must have exhausted other approved treatments, including erdafitinib for bladder cancer, …

This phase 2 study is testing a new treatment called TARA-002 for people with a type of high-grade bladder cancer that hasn't spread into the muscle. The treatment is given directly into the bladder through a catheter once a week for 6 weeks. The study will include about 131 adul…

This study looks at whether taking vitamin B3 (a common dietary supplement) can stop antibiotics from weakening the immune system's ability to fight bladder cancer. The trial includes people with a certain type of bladder cancer who have recently taken antibiotics. They will rece…

This Phase 2 trial tests an oral drug called TYRA-300 in 90 adults with a low-grade, intermediate-risk bladder cancer that has not invaded muscle. The cancer must have a specific genetic change (FGFR3 alteration). Participants take a daily tablet for up to 2 years. The main goal …

This phase 3 trial tests whether a new drug, TARA-002, works better than standard chemotherapy for a type of early-stage bladder cancer. About 284 adults who have not received BCG therapy will be randomly assigned to receive either TARA-002 or chemotherapy directly into the bladd…

This study is testing the drug T-DXd (Enhertu) in 100 adults with advanced HER2-positive solid tumors who have already tried other treatments and have no good options left. The goal is to see how well the drug works in real-world settings, including how many patients respond and …

This study is checking how well the Altaviva™ device works over five years for people with sudden, strong urges to urinate (urge incontinence). The device sends mild electrical pulses to a nerve in the ankle to calm bladder signals. Researchers will track 256 adults to see if at …

This phase II trial is testing whether giving the immunotherapy drug pembrolizumab along with radiation therapy after chemotherapy can help patients with muscle invasive bladder cancer avoid bladder removal surgery. About 111 participants who responded well to initial chemotherap…

This study tests whether adding an experimental drug (MK-3120) to the standard treatment (enfortumab vedotin plus pembrolizumab) is safe and effective for people with advanced bladder cancer that has spread. About 55 participants will receive the new combination. Researchers will…

This early-stage trial tests a new type of immunotherapy called 4SCAR-T cells in 20 people with advanced bladder cancer that has spread and no longer responds to standard treatments. The cells are genetically modified to recognize and attack cancer cells. The study aims to see if…

This early-stage trial is testing a new type of radiation therapy that seeks out and attacks cancer cells while sparing healthy tissue. It's for people with advanced breast, lung, stomach, or bladder cancer who have run out of standard options. The study will check if the treatme…

This study tests a special scaffold placed during prostate removal surgery to help men regain bladder control. About 266 men will be randomly assigned to get the scaffold or standard care. The goal is to see if the scaffold reduces urine leakage and improves quality of life over …

This Phase II trial is testing whether adding the immunotherapy drug atezolizumab to standard chemotherapy (platinum and etoposide) before bladder removal surgery can completely eliminate the cancer in people with a rare, aggressive form of bladder cancer called small cell neuroe…

This phase III trial tests whether combining two drugs—pembrolizumab (an immunotherapy) and sacituzumab govitecan (a targeted chemotherapy)—works better than standard chemotherapy for people with advanced bladder cancer that has stopped responding to initial immunotherapy. About …

This study tests a personalized vaccine made from a patient's own tumor proteins, given alone or with the immunotherapy drug pembrolizumab. The goal is to see if the combination is safe and helps the immune system attack advanced solid tumors. About 132 people with various advanc…

This phase II trial compares two treatments for high-grade T1 bladder cancer that hasn't spread. One group gets the immunotherapy drug pembrolizumab plus radiation, while the other gets standard chemotherapy (cisplatin, gemcitabine, 5-fluorouracil, or mitomycin-C) plus radiation.…

This study tests a new drug called MK-3120 for high-risk non-muscle invasive bladder cancer. After standard tumor removal, 45 participants will receive the drug directly into the bladder. The main goals are to check safety and how well people tolerate it, while also looking at tu…

This study tests whether adding a new targeted medicine (vepugratinib) to two standard cancer drugs can help people with advanced bladder cancer that has a specific genetic change (FGFR3). About 450 adults whose cancer has spread or cannot be removed by surgery will take part. Th…

This phase 2 trial is testing a combination of two drugs, enfortumab vedotin and pembrolizumab, in people with rare cancers of the bladder, urinary tract, or testicles. The study aims to see if these drugs can shrink tumors or slow disease progression. About 68 adults will receiv…

This study tests an experimental mRNA therapy called mRNA-4359, given alone or with standard immunotherapy drugs, in people with advanced solid tumors (like melanoma, lung cancer, or colorectal cancer). The main goals are to find a safe dose and see if the treatment can shrink tu…

This early-stage trial is testing a new drug called IDE892, alone or with another drug (IDE397), in people with advanced solid tumors that have a specific genetic deletion (MTAP). The study aims to find safe doses and see if the drugs shrink tumors. It includes 260 adults with ca…

This phase II trial tests whether a 12-week course of higher-dose antibiotics combined with a urinary antiseptic (methenamine hippurate) can better control chronic UTI than standard low-dose antibiotics or antiseptic alone. About 192 adults with daily UTI symptoms for at least 3 …

This trial tests whether a new robotic system that uses only one small incision (single port) can safely perform common abdominal surgeries in children. The study includes children aged 1 to 17 who need procedures like pyeloplasty or reflux treatment. The goal is to see if the si…

This study tests a new drug called EG-70 (detalimogene) for a type of bladder cancer called non-muscle invasive bladder cancer (NMIBC). The drug is given directly into the bladder through a catheter. The trial includes patients whose cancer did not respond to standard BCG therapy…

This trial tests a device called Adjustable Continence Therapy (ACT) for women with stress urinary incontinence caused by a weak urethral sphincter. The implant has two balloons placed near the bladder neck that can be adjusted after surgery to improve control. The study will enr…

This phase 3 trial is testing a gene therapy called nadofaragene firadenovec, given directly into the bladder, either alone or combined with chemotherapy or immunotherapy. It is for people with a type of bladder cancer that has not responded to standard BCG therapy. The study aim…

This early-stage trial tests a new drug called LY4052031, which is designed to deliver a cancer-killing agent directly to tumor cells that have a protein called Nectin-4. The study includes 420 adults with advanced or metastatic solid tumors such as bladder, breast, lung, and oth…

This early-stage trial is testing a new oral drug called LOXO-435, alone or with other cancer medicines, in people with advanced solid tumors that have a specific change in the FGFR3 gene. The study aims to find the right dose and check for safety and early signs of effectiveness…

This study tests a daily pill called vibegron to see if it safely improves bladder control in children aged 2 to 18 with neurogenic detrusor overactivity (NDO), a condition where the bladder contracts too often due to nerve damage. Participants must already use a catheter to empt…

This early-phase trial is testing whether combining the drug enfortumab vedotin with radiation therapy can help control locally advanced bladder cancer. About 41 adults with urothelial carcinoma of the bladder will receive the drug by IV along with radiation. The main goal is to …

This study is following 55 adults who have an implanted device that stimulates nerves to control overactive bladder. Researchers want to see if the device safely improves quality of life over the long term. Participants must have already tried other treatments without success.

This study tests whether a new combination of drugs (enfortumab vedotin plus toripalimab) works better than standard chemotherapy before bladder cancer surgery. About 58 adults with high-risk muscle-invasive bladder cancer will be randomly assigned to one of the two treatments fo…

This early-stage trial is testing a new drug called AB821 in 50 adults with advanced melanoma or other solid tumors that respond to immune therapies. The main goal is to check safety and find the right dose. Participants receive AB821 by IV every 2 or 3 weeks for up to two years.

This study tests a new device called the Enhanced Lithotripsy System (ELS) that uses low-pressure ultrasound to activate tiny bubbles in the urine, breaking kidney or ureter stones into small pieces that can pass naturally. The trial will enroll 101 adults with a single stone in …

This study looks at whether surgery to remove remaining cancer spots can help people with advanced bladder cancer that has been controlled by drug therapy. About 32 adults whose cancer has not spread widely will receive surgery on the main tumor and any other treatable spots. The…

This phase II trial is testing the drug pemetrexed in people with advanced bladder cancer or other solid tumors that have spread and carry certain gene mutations (MLL4, UTX, or MTAP). The goal is to see if pemetrexed can shrink tumors. About 64 participants will receive the drug …

This study investigates whether combining the immunotherapy drug durvalumab with a cancer vaccine (S-488210/S-488211) can help people with a type of bladder cancer that has not responded to standard treatment. The trial includes adults with high-risk non-muscle invasive bladder c…

This study tests whether adding the immunotherapy drug durvalumab to standard chemotherapy before and after bladder cancer surgery is safe and effective. About 150 people with muscle-invasive bladder cancer will receive durvalumab plus either ddMVAC or gemcitabine/cisplatin chemo…

This phase II trial is testing a combination of two drugs—disitamab vedotin given through a vein and mitomycin C placed directly into the bladder—in 30 people with a specific type of non-muscle-invasive bladder cancer that has a protein called HER2. The goal is to see if this tre…

This study tests a new drug called Sacituzumab Tirumotecan (Sac-TMT) for people with a type of bladder cancer that hasn't spread into the muscle. The drug is given directly into the bladder through a catheter. The main goals are to find the safest dose and see if people can toler…

This study tests a decision tool to help select women with bladder cancer who can safely keep their reproductive organs during bladder removal surgery. Currently, standard surgery removes the bladder, uterus, ovaries, and part of the vagina, which can harm sexual health, mental h…

This phase 2 trial tests whether adding a personalized cancer vaccine (autogene cevumeran) to the immunotherapy drug nivolumab can prevent high-risk bladder cancer from coming back after surgery. About 62 participants will receive either the combination or nivolumab alone. The st…

This study compares two procedures for stress urinary incontinence (leaking urine with cough, sneeze, or exercise) in 358 women. One group gets a bulking agent injection to thicken the urethra lining; the other gets a small mesh sling to support the urethra. The goal is to see wh…

This phase III trial tests whether adding local radiotherapy to standard care helps bladder cancer patients who are not eligible for curative treatment live longer and feel better. About 248 participants will be randomly assigned to receive either standard care alone or standard …

This study looks at people with a sudden kidney blockage from a stone in their only working kidney. Doctors will randomly use either a tube placed through the bladder or one through the back to drain urine. The goal is to see which method helps kidney function recover better and …

This study is for people with muscle-invasive bladder cancer that has not spread. It tests whether removing only the part of the bladder with cancer (partial cystectomy) plus nearby lymph nodes works as well as removing the whole bladder. Participants get standard chemotherapy be…

This study follows about 195 women for up to 10 years after they receive a mesh sling (GYNECARE TVT ABBREVO) to treat stress urinary incontinence (leaking urine when coughing, sneezing, or exercising). The main goal is to see how many women are still dry after 5-10 years. Partici…

This early-stage trial tests a new drug called IAM1363 in adults with advanced cancers that have HER2 alterations, including breast, lung, and stomach cancers that have spread to the brain. The study aims to find the safest dose and see if the drug can shrink tumors. About 383 pa…

This study compares a new drug delivery system (TAR-210) that releases erdafitinib directly into the bladder versus standard chemotherapy for people with intermediate-risk non-muscle invasive bladder cancer that has certain genetic changes (FGFR alterations). About 641 participan…

This study tests whether injecting a substance made from donated amniotic membrane into the bladder can reduce pain and urgency in women with interstitial cystitis (painful bladder syndrome). One hundred women who have not gotten better with other treatments will receive either t…

This study is tracking 150 people with early-stage bladder cancer who are receiving TAR-200, a treatment placed directly into the bladder. Researchers want to see how long it takes for the cancer to come back or get worse in real-world settings, not just in controlled trials. The…

This study tests a new medicine, PF-08634404, in adults with advanced bladder cancer that has spread. Some participants receive the drug alone, while others get it combined with another cancer drug. The goal is to check safety, how well it works, and how it affects the body. Abou…

This program provides the experimental drug ulixertinib to people with advanced solid tumors that have certain gene mutations (MAPK pathway). It is for patients who have not responded well to or have run out of standard treatments. The goal is to control the disease and possibly …

This phase 3 trial tests a new drug, TAR-210 (erdafitinib), placed directly into the bladder, against standard chemotherapy for people with a high-risk type of bladder cancer that has come back after BCG treatment. The study includes 220 adults whose tumors have certain FGFR gene…

This study tests whether giving two drugs (enfortumab vedotin and pembrolizumab) before bladder cancer surgery can eliminate cancer in the lymph nodes and shrink tumors. About 23 adults with advanced bladder cancer that has spread to lymph nodes will receive the combination befor…

This phase II trial tests two drugs, lurbinectedin and avelumab, in people with a rare and aggressive bladder cancer called small cell carcinoma. Participants who have already had a drug like avelumab will receive only lurbinectedin; others will get both. The study aims to see if…

This early-phase study tests two drugs, bintrafusp alfa and PDS01ADC, alone or with targeted radiation, in 100 adults with metastatic bladder, kidney, or other non-prostate genitourinary cancers. The goal is to see if the combination can help the immune system fight cancer better…

This study tests a drug called erdafitinib, placed directly into the bladder using a special delivery system, for people with non-muscle-invasive or muscle-invasive bladder cancer. The trial has four parts to find the best dose and check safety and effectiveness. About 235 partic…

This Phase 2 trial tests an oral drug called BAY 2927088 (sevabertinib) in about 111 adults with advanced solid tumors that have HER2 gene mutations. The drug aims to block the abnormal HER2 protein and stop cancer growth. Participants take a 20 mg tablet daily in 3-week cycles u…

This early-stage trial tests a new drug called MST-0312, designed to help the body's immune system fight cancer more effectively. It is being studied alone or with another cancer drug (pembrolizumab) in people with several types of solid tumors, including lung, melanoma, bladder,…

This study tests a new drug called ifinatamab deruxtecan in people with advanced solid tumors that have not been cured by other treatments. The goal is to find the safest dose and see if the drug can shrink tumors. About 250 participants will take part, and those who benefit may …

This phase 2 trial tests a two-drug combination (mitomycin-C and gemcitabine) given directly into the bladder for people with high-risk bladder cancer that did not respond to BCG therapy. The study will enroll 82 participants to see if this sequential treatment can prevent cancer…

This study tests a new treatment for people with a high-risk type of bladder cancer that did not get better after standard BCG therapy. The treatment combines two chemotherapy drugs placed directly into the bladder with an immunotherapy drug given through a vein. The goal is to s…

This study tests a new drug called STM-416 that is applied directly to the bladder during surgery to remove tumors. It is for people with a type of bladder cancer that keeps coming back. The goal is to see if the drug is safe and can help keep the cancer from returning. About 75 …

This study tests whether a urine DNA test can help guide when to stop immunotherapy in people with a very high-risk type of bladder cancer that cannot be fully removed by surgery. About 53 participants will receive immunotherapy and then be monitored with urine tests and scans. I…

This study tests a new drug that delivers radiation directly to cancer cells carrying a protein called DLL3, found in small cell lung cancer and other solid tumors. The trial enrolls 138 adults whose cancer has progressed after at least two prior treatments. The goal is to check …

This study tests whether adding the drug tarlatamab to standard radiation therapy is safe for people with cancers that have a protein called DLL3, including melanoma, lung cancer, and glioblastoma. About 30 adults with advanced or returning cancers will receive tarlatamab infusio…

This phase 2 trial is testing an experimental drug called patritumab deruxtecan (HER3-DXd) in 740 people with advanced solid tumors, including melanoma, lung, breast, and other cancers. The drug is given by IV every three weeks. The main goal is to see if the drug shrinks tumors.…

This study is testing a new experimental drug called GI-101, given alone or with pembrolizumab or lenvatinib, in people with advanced or metastatic solid tumors (cancers that have spread). The goal is to see if the drug is safe and can shrink or control tumors. About 317 adults w…

This study tests a small, implanted device that stimulates the pudendal nerve to help control bladder function in women with mixed urinary incontinence (both stress and urge leaks). The device is personalized and adapts to each person's needs. Researchers will check if the proced…

This study tests a new drug called BNT329 in people with advanced solid tumors that have a specific marker (CA19-9). The main goals are to check safety and find the best dose. About 245 participants will take part. The drug works by targeting cancer cells and may help control tum…

This early-stage trial is testing whether it is safe to give immunotherapy (nivolumab) together with radiation therapy after bladder cancer surgery. The study will enroll 10 people who have had their bladder removed. The main goal is to see if this combination causes serious side…

This study tests a new technique called Burst Wave Lithotripsy (BWL) that uses bursts of low-amplitude ultrasound to break kidney stones into tiny pieces during a standard surgical procedure. About 40 adults scheduled for stone removal will receive BWL to see if it is safe and ef…

This expanded access program offers a modified tuberculosis vaccine (recombinant BCG) to people with non-muscle invasive bladder cancer who cannot join a clinical trial. The treatment is given directly into the bladder and aims to control the disease. It is only for patients who …

This early-stage trial is testing a new drug called sigvotatug vedotin, alone or with other cancer medicines, in people with advanced solid tumors like lung, head and neck, and breast cancers. The study aims to find a safe dose and check for side effects. About 1,000 participants…

This study compares different FDA-approved drugs for a type of bladder cancer that hasn't spread into the muscle. About 125 adults whose previous treatment with BCG didn't work will receive either a newer gene therapy or standard drugs. The goal is to see which treatment better p…

This study tests whether a procedure that filters a patient's blood (therapeutic plasma exchange) can help standard cancer drugs work better in people with advanced bladder or urinary tract cancer that has stopped responding to previous treatments. About 70 adults will be randoml…

This early-stage study tests a new drug called 2141-V11 in people with a type of bladder cancer that hasn't responded to standard therapy. The drug is given directly into the bladder through a catheter or by injection into the tumor. The main goal is to see if it's safe and to fi…

This study tests a healthy eating program that encourages people with early-stage bladder cancer to eat more cruciferous vegetables like broccoli, kale, and cabbage. These veggies contain natural compounds that may help fight cancer cells. Researchers want to see if this diet cha…

This early-phase trial is testing whether a combination of two drugs, atezolizumab and tiragolumab, can help control bladder cancer when given before surgery to remove the bladder and tumor. The study includes 10 adults with muscle-invasive bladder cancer who cannot take standard…

This study compares two radiation schedules for people with muscle-invasive bladder cancer who also receive chemotherapy. One group gets the usual number of radiation treatments, while the other gets fewer, higher-dose sessions. The goal is to see if the shorter course works just…

This study tests a treatment plan for people with a rare, aggressive type of bladder cancer (variant histology) that has grown into the muscle layer. The goal is to see if giving chemotherapy (with or without immunotherapy) followed by radiation and low-dose chemo can save the bl…

This study compares 3 versus 6 cycles of platinum-based chemotherapy followed by the immunotherapy drug avelumab in 320 people with advanced bladder cancer. The goal is to see if fewer chemo cycles improve quality of life without harming cancer control. Participants receive eithe…

This study tests a two-drug combination (gemcitabine and Jelmyto) given in sequence to treat a high-risk type of upper urinary tract cancer. The goal is to destroy the tumor without removing the kidney, which is the usual treatment. About 28 adults with non-invasive, high-grade c…

This study looks at two ways to manage recurrent urinary tract infections (UTIs) in women. One group takes a daily antibiotic called nitrofurantoin. The other group has a minor procedure to burn away tiny spots in the bladder (electrofulguration) and also takes the daily antibiot…

This study is for people with bladder cancer that has spread to a small number of other body parts (up to 3 spots). It compares standard treatment (chemotherapy or immunotherapy) alone versus standard treatment plus a precise, high-dose radiation therapy called SBRT. The goal is …

This phase 2 trial tests whether combining two drugs—sacituzumab govitecan and nivolumab—after surgery can keep high-risk bladder cancer from coming back. About 23 adults who had their bladder or part of their urinary tract removed will receive the drugs intravenously. The main g…

This early-phase trial is testing whether combining two drugs—cabozantinib and enfortumab vedotin—can safely treat advanced bladder cancer that has spread. About 32 adults whose cancer worsened after standard treatments will receive the combo. The study aims to find the best dose…

This early-phase trial is testing a new radioactive drug that seeks out a protein called Nectin-4 found on many cancer cells. The drug delivers a dose of radiation directly to the tumor, aiming to destroy it while sparing healthy tissue. About 150 adults with advanced bladder, br…

This phase 2 trial is testing a treatment called cretostimogene grenadenorepvec, a modified virus designed to infect and destroy cancer cells, in 16 people with high-risk bladder cancer that has not responded to standard BCG therapy. The study aims to see if the treatment can mak…

This early-phase trial tests an experimental drug called GTB-5550 in adults with advanced solid tumors that have stopped responding to standard treatments. The drug is a nanobody designed to bridge natural killer cells to cancer cells, helping the immune system attack the tumor. …

This study tests a new drug called PF-08052667 for adults with a type of bladder cancer that hasn't spread into the muscle layer but is likely to return. The drug is given directly into the bladder, sometimes with other medicines like BCG or sasanlimab. The trial has three parts …

This early-phase trial at Mayo Clinic is testing whether it is possible to transplant a bladder along with a kidney in people who have kidney failure due to bladder problems. Up to 30 participants will receive both organs from a deceased donor. The goal is to see if the bladder w…

This phase 2 trial is testing whether two chemotherapy drugs, gemcitabine and docetaxel, given directly into the bladder can treat high-risk bladder cancer that did not respond to standard BCG therapy. About 174 adults will receive weekly treatments for 6 weeks, then monthly for …

This study tests whether adding high-dose vitamin D to standard care helps children with overactive bladder (wet) reach their goal of zero leakage. About 180 children aged 5 and older with low vitamin D levels will receive either standard treatment alone or standard treatment plu…

This phase 1/2 trial tests the immunotherapy drug durvalumab alone or combined with other treatments (BCG, radiation, or chemotherapy) in 55 people with non-muscle invasive bladder cancer. The goal is to find safe doses and see if these combinations can eliminate cancer and preve…

This early-stage trial is testing a new drug called belzupacap sarotalocan (AU-011) for people with non-muscle-invasive bladder cancer. The drug is injected directly into the tumor, sometimes with a laser. The main goal is to see if this approach is safe and feasible. About 55 pa…

This study tests the drug nivolumab in people with advanced rare cancers that have a specific marker (PD-L1). The goal is to see if the drug can shrink or control the tumors when other treatments have stopped working. Up to 28 adults will receive treatment for up to 12 months, an…

This program provides early access to cretostimogene grenadenorepvec, a virus-based therapy, for patients with non-muscle invasive bladder cancer that has not responded to standard BCG treatment. Eligible participants have a specific type of bladder cancer (CIS with or without hi…

This study tests two drugs, durvalumab and monalizumab, given together to people with a type of bladder cancer that has not gotten better with standard treatment. The goal is to see if the combination can make the cancer disappear or stop it from growing. About 60 adults will tak…

This Phase 2 trial tests a drug called cretostimogene grenadenorepvec in 325 people with high-risk non-muscle-invasive bladder cancer. The drug is a virus that is put directly into the bladder to attack cancer cells. The study looks at how well it works and how safe it is, includ…

This early-phase study tests an experimental drug called PF-08046876 in about 310 adults with advanced cancers of the bladder, lung, head and neck, esophagus, or pancreas that have not responded to standard treatments. The drug is a type of 'antibody drug conjugate' designed to s…

This early-stage trial is testing a new treatment called VET3-TGI, a virus designed to infect and destroy cancer cells. It is being given alone or with the immunotherapy drug atezolizumab to 60 people with advanced solid tumors that have not responded to standard treatments. The …

This early-stage trial is testing a new version of the BCG therapy, made from a genetically modified bacterium, for people with non-muscle invasive bladder cancer (NMIBC) who have not received BCG before. The treatment is given directly into the bladder through a catheter. The st…

This study is testing a new device called UrOActive®, an artificial urinary sphincter, in 140 men with stress urinary incontinence (leakage when coughing, sneezing, or moving). The device is implanted to help control urine flow. The main goal is to see if it reduces leakage by at…

This early-stage study tests a new treatment for people with advanced bladder cancer that has not responded to standard therapies. The treatment uses specially engineered immune cells (CAR-NK cells) from a healthy donor, designed to target two proteins on cancer cells. Participan…

This phase 3 trial is testing a new version of the BCG vaccine, called Verity-BCG, against the standard BCG treatment (OncoTICE) in 540 people with intermediate or high-risk non-muscle invasive bladder cancer who have not received BCG before. The goal is to see if Verity-BCG is a…

This study looks at whether a heart procedure called left atrial occlusion can help patients who have both atrial fibrillation (an irregular heartbeat) and radiation cystitis (bladder inflammation from cancer treatment). These patients often take blood thinners to prevent strokes…

This study tests whether low-intensity shockwave therapy can improve overactive bladder symptoms in women as well as or better than the standard drug solifenacin. Seventy women will be randomly assigned to receive either weekly shockwave sessions for 8 weeks or a daily pill for 1…

This study tests a drug called sacituzumab govitecan in people with advanced bladder cancer that has spread and cannot be removed by surgery. The goal is to see if the drug can shrink tumors and control the cancer. About 827 adults with good organ function and a life expectancy o…

This study tests a comprehensive fitness and nutrition program (prehabilitation) given before major cancer surgery. It includes 148 patients with pancreatic, ovarian, kidney, or bladder cancer who are frail or pre-frail. Some patients get the program alone, others get it with che…

This early-stage trial tests a new treatment called PLZ4-coated paclitaxel-loaded micelles (PPM) for people with non-muscle invasive bladder cancer that has come back or not responded to standard therapy. PPM is a nanoparticle designed to deliver chemotherapy directly to tumor ce…

This early-phase trial tests whether combining the drug sacituzumab govitecan with advanced radiation therapy is safe and tolerable for people with muscle-invasive bladder cancer that hasn't spread. The goal is to treat the cancer while preserving the bladder, avoiding surgical r…

This phase 2 trial tests whether giving two chemotherapy drugs (gemcitabine and docetaxel) directly into the bladder can prevent low-grade bladder cancer from coming back. About 34 adults with intermediate-risk disease will receive the treatment. The main goal is to see how long …

This early-stage trial is testing a new peptide vaccine (IO102-IO103) combined with the immunotherapy drug pembrolizumab (Keytruda) in 30 adults with high-risk non-muscle invasive bladder cancer that did not respond to or could not tolerate standard BCG therapy. The vaccine is de…

This study tests a gene therapy called Neovasculgen in 180 women with painful bladder syndrome and Hunner's lesions. The goal is to reduce scarring from previous treatments and prevent the bladder from shrinking. Participants receive either the drug or a placebo, and doctors chec…

This study looks at how two different types of bladder medication affect thinking skills in women aged 60 and older who have sudden, strong urges to urinate. Participants will be randomly assigned to take one of two drugs or a placebo for 6 months. The goal is to see which option…

This Phase 1 trial tests IDOV-Immune, a genetically engineered virus designed to infect and destroy cancer cells while boosting the immune system. It is for adults with advanced solid tumors (like colorectal, pancreatic, or lung cancer) that have not responded to standard treatme…

This study looks at whether a thorough health check (comprehensive geriatric assessment) before bladder cancer surgery can help older, frail patients recover faster. About 140 people aged 65 and older will be enrolled. The goal is to see if personalized care plans reduce complica…

This study tests a combination of two chemotherapy drugs (gemcitabine and docetaxel) given directly into the bladder for people with non-muscle invasive bladder cancer. The goal is to see if this treatment can control or eliminate tumors, especially for those who cannot get stand…

This phase 2 trial tests two drugs, enfortumab vedotin and pembrolizumab, in 47 people with muscle-invasive bladder cancer. The goal is to see if the combination can eliminate the cancer so patients can keep their bladder instead of having it surgically removed. After three cycle…

This trial tests a procedure called fetal cystoscopy for unborn male babies with a severe blockage in the urinary tract (LUTO). Doctors insert a tiny telescope through the mother's belly into the baby's bladder to diagnose and treat the blockage with a laser. The study will enrol…

This study tests a new treatment called EBNK-001, made from donor immune cells (natural killer cells), in people with advanced solid tumors that have not responded to standard therapies. Participants receive the cells after chemotherapy to prepare the body, along with low-dose in…

This study tests a new treatment for muscle-invasive bladder cancer that aims to save the bladder. It combines two drugs (enfortumab vedotin and pembrolizumab) with targeted radiation. About 47 adults with this cancer will receive the therapy to see if it can shrink tumors and av…

This study tests whether a maintenance drug (pembrolizumab) can help control advanced bladder cancer after an initial 18-week combination treatment. About 97 people who have not had prior therapy for metastatic disease will participate. The goal is to see if this approach improve…

This trial tests an experimental drug called CP-383 in people with advanced solid tumors (like lung, colon, or pancreatic cancer) that have not responded to standard treatments. The drug is taken daily by mouth and works by blocking a process cancer cells need to grow. The study …

This study tests whether giving a targeted drug (enfortumab vedotin) plus an immunotherapy (pembrolizumab) before surgery to remove part or all of the bladder can improve outcomes for people with advanced bladder or urinary tract cancer. About 75 adults with cancer that has sprea…

This early-phase trial is testing a new drug called CLSP-1025 in about 90 adults with advanced solid tumors (like lung, colon, or breast cancer) that have a specific p53 mutation (R175H). The drug works by directing the body's immune cells to attack cancer cells carrying this mut…

This study tests whether a new type of radiation machine that uses MRI to guide treatment is safe and practical for people with gastric, breast, or other cancers. About 70 adults will receive radiation guided by real-time MRI, sometimes with chemotherapy. The goal is to see if th…

This early-phase trial tests MGC026, a biologic drug given by IV, in 250 adults with advanced solid tumors that have not responded to standard treatments. The study has two parts: first, finding a safe dose, then expanding to see if the drug shrinks tumors. Participants receive u…

This early-stage trial tests a new combination treatment for people with advanced HER2-positive solid tumors (like breast, lung, or stomach cancer). Participants receive an injection of a special virus directly into one tumor to help the immune system attack cancer, followed by a…

This early study tests a single treatment of EG110A injections into the bladder muscle for adults with spinal cord injury who still have bladder leaks despite standard care. The goal is to see if the treatment is safe and can reduce incontinence. Sixteen participants will be foll…

This study tests a gene therapy called Neovasculgen for people with painful bladder syndrome/interstitial cystitis, a condition causing pelvic pain and frequent urination. The treatment is injected into the bladder wall during a procedure. The goal is to reduce pain and prevent t…

This study tests whether growing a patient's tumor cells in the lab (organoids) can help doctors choose the most effective chemotherapy after bladder cancer surgery. Researchers will compare survival rates of patients whose chemo was guided by organoid tests versus standard care.…

This study uses lab-grown mini-tumors (organoids) from bladder cancer patients to see which anti-HER-2 drug works best. It compares survival rates of patients whose treatment is guided by these organoids versus standard protein testing. The goal is to improve one-, two-, and thre…

This study is testing a small device called eCoin that is implanted under the skin to stimulate a nerve in the leg. The goal is to reduce sudden, strong urges to urinate that lead to leaks. Researchers will track 200 adults with overactive bladder to see if the device safely cuts…

This study tests a new drug called WEF-001 in people with advanced solid tumors that have a KRAS mutation, including pancreatic, colorectal, and lung cancers. The goal is to check the drug's safety and how well it shrinks tumors. About 110 adults who have already tried standard t…

This study looks at two common choices during bladder cancer removal surgery: using a ureteral stent (a tube to drain urine) and giving the drug alvimopan to help the bowels work sooner. The goal is to see if these choices affect how long patients stay in the hospital and how man…

This study compares two types of lasers used to break up kidney stones during a minimally invasive procedure called ureteroscopy. One laser uses a superpulse thulium fiber (sTFL), the other is a standard holmium laser. Researchers will enroll 136 adults aged 18–70 with kidney sto…

This early-stage trial tests a modified virus called KD01, given directly into the bladder, to see if it is safe and can fight bladder cancer. The study includes 29 patients with either high-risk non-muscle-invasive bladder cancer or muscle-invasive bladder cancer. Some patients …

This study compares two surgical procedures for stress urinary incontinence in women aged 60 and older: a synthetic mesh sling (TVT) and a sling made from the patient's own tissue (autologous fascia). Researchers will track new pelvic pain at 6 months and cure rates at 5 years, a…

This phase II trial tests two drugs—enfortumab vedotin and pembrolizumab—in 20 people with high-grade upper tract urothelial cancer who cannot or choose not to have surgery to remove the kidney and ureter. The goal is to see if the combination can control the cancer and preserve …

This study is testing a new way to deliver radiation for prostate and bladder cancers. The approach uses an MRI-guided machine to adapt the radiation dose in real time, giving a higher boost to the tumor while sparing nearby organs. Researchers want to see if this reduces side ef…

This study tests a new tablet called ABP1011T in people with advanced solid tumors, including small cell lung cancer and others like esophageal or bladder cancer. Participants take one pill daily in 21-day cycles. The goal is to see if the drug can shrink tumors and how safe it i…

This study compares two approaches for treating non-muscle invasive bladder cancer. The standard approach uses two surgeries: one to remove the tumor and a second to check for leftover cancer. The new approach uses a single, enhanced surgery with a special dye and light to better…

This study tests a drug called trastuzumab rezetecan in people with advanced solid tumors that have stopped responding to standard therapies. The drug is given every three weeks to 90 participants divided into three groups based on their cancer type. Researchers will measure how …

This study tests whether adding an immunotherapy drug (toripalimab) to standard BCG therapy can help people with high-risk bladder cancer avoid bladder removal. About 31 participants will receive the combination after surgery. The main goal is to see if the cancer disappears with…

This early-stage trial tests a new drug called ONM-501, which is injected directly into tumors, either alone or with the immunotherapy cemiplimab (Libtayo). The study includes 168 adults with advanced solid tumors or lymphomas that have not responded to standard treatments. The m…

This study tests whether a combination of two targeted drugs (zanidatamab and tislelizumab) plus chemotherapy can shrink HER2-positive muscle-invasive bladder cancer enough to avoid bladder removal. About 25 adults with stage T2-T4a bladder cancer will receive the treatment befor…

This study tests whether using MRI scans to guide brachytherapy (a type of internal radiation) can better target tumors in gynecologic cancers like cervical, uterine, vaginal, vulvar, and bladder cancers. The goal is to see if MRI guidance reduces radiation exposure to nearby hea…

This study tests a new treatment called GO306, a modified virus designed to infect and destroy cancer cells. It is for adults with advanced solid tumors (like breast, colon, or kidney cancer) that have not responded to standard therapies. The main goal is to check the safety of t…

This study tests whether adding the drug bicalutamide to standard BCG therapy can help prevent bladder tumors from returning in men with non-muscle invasive bladder cancer. About 160 participants will be randomly assigned to receive either BCG alone or BCG plus bicalutamide. The …

This phase 2 trial tests erdafitinib alone or with cetrelimab before surgery in 90 people with muscle-invasive bladder cancer that has specific gene changes (FGFR). Participants cannot take standard cisplatin chemotherapy. The goal is to see if the drugs can eliminate or shrink t…

This study tests two drugs, futibatinib and durvalumab, given before surgery to remove the bladder in people with muscle-invasive bladder cancer who cannot take standard chemotherapy. The goal is to see if this combination can eliminate or shrink the cancer enough to improve outc…

This study tests if rinsing the new bladder or urine pouch with a chlorhexidine antiseptic during and after bladder cancer surgery can prevent urinary tract infections. About 23 adults having bladder removal and reconstruction will participate. The main goal is to see if urine is…

This study tests whether giving patients a special nutritional drink (immunonutrition) before bladder removal surgery can reduce complications like infections. About 232 adults having open cystectomy for various bladder conditions will be randomly assigned to receive the drink or…

This study tests whether giving a combination of adebrelimab (an immunotherapy) plus chemotherapy before bladder removal surgery can completely eliminate neuroendocrine bladder cancer in 22 adults. Participants will receive up to 4 cycles of the drug combo before surgery. The mai…

This trial tests two drugs, trastuzumab and pertuzumab, already approved for breast cancer, in people with rare cancers that have a specific genetic change called HER2 amplification or mutation. About 30 adults and children with various rare or hard-to-treat cancers will receive …

This study tests a new drug called Ruvidar, given directly into the bladder, for people with a type of bladder cancer that did not respond to or could not tolerate standard BCG therapy. About 90 adults will receive up to three treatment sessions. The main goal is to see if the dr…

This study looks at whether giving patients IV fluids at home for four weeks after bladder cancer surgery can lower the chance of needing to go back to the hospital. About 130 adults having this surgery will be randomly assigned to either get the usual care or the usual care plus…

This study tests whether adding focused radiation to standard treatment helps people with metastatic bladder cancer live longer. It includes patients whose cancer has not worsened after initial therapy and who have three or fewer remaining tumors. About 130 participants will be r…

This study tests whether using blue light during bladder tumor removal surgery helps surgeons see and remove more cancer than standard white light. About 200 adults with high-risk non-muscle invasive bladder cancer will be randomly assigned to one of the two methods. The goal is …

This study looks at whether it is safe to skip preventive antibiotics after bladder removal surgery for muscle-invasive bladder cancer. Half of the 120 participants will take nitrofurantoin daily for 10–21 days after surgery, while the other half will receive no antibiotics. The …

This study is for people with metastatic urothelial cancer (a type of bladder cancer that has spread). It tests two or three drugs together: sacituzumab govitecan, enfortumab vedotin, and pembrolizumab. The goal is to find the safest doses and see how well the combination shrinks…

This study is testing whether a urine test can accurately detect urothelial carcinoma, a type of cancer that includes bladder cancer. Researchers are comparing the test results to standard tissue biopsies in 800 adults with blood in their urine and suspicious imaging findings. If…

This study is testing whether a new blood test can screen for many types of cancer at once. Researchers will enroll 24,000 adults aged 45-75 who do not have cancer. Participants will be randomly assigned to one of two blood test groups or a control group. The goal is to see how w…

This study is testing a new urine test called UroAmp to see if it can accurately detect bladder cancer and monitor for its return. Researchers will collect urine and tumor samples from 2,500 people being evaluated or treated for bladder cancer or related conditions. The goal is t…

This study is testing whether an ultrasound-guided core needle biopsy can accurately determine the stage of bladder cancer. Researchers will compare the biopsy results with the final stage found during standard surgery. The goal is to see if this less invasive method can be a rel…

This study collects video recordings and data from 500 patients undergoing blue light cystoscopy, a procedure where a drug makes cancer cells glow. The goal is to train an artificial intelligence (AI) algorithm to detect bladder lesions in real time, helping doctors make more acc…

This study compares three imaging methods—FAPI PET/MRI, FDG PET/MRI, and MRI—to see which best detects muscle-invasive bladder cancer and tracks how well pre-surgery treatment works. Researchers will enroll 80 participants with suspected or confirmed bladder cancer. The goal is t…

This study is testing a new type of PET scan that uses special radioactive tracers to find and map solid tumors in the body. The tracers target a protein called Trop2, which is often found on cancer cells. Researchers will enroll 400 people with various cancers (including bladder…

This study compares CT and MRI scans to see which more accurately determines if bladder cancer has spread into the muscle layer. About 150 adults with newly diagnosed bladder cancer will receive both scans before standard surgery. The results will be checked against tissue sample…

This study tests whether a new imaging agent called [18F]FAPI-74 can find certain cancers as well as or better than the standard PET tracer. About 320 adults with one of 11 cancer types (including pancreatic, liver, ovarian, and lung cancers) will receive both tracers and have th…

This study is testing the NXT Urodynamics System, a device used to measure how well the bladder stores and releases urine. Researchers want to confirm it is safe and works correctly in people with bladder problems like incontinence or overactive bladder. About 180 adults who need…

This study looks at whether a simple urine test for tumor DNA can tell which bladder cancer patients truly need a second surgery after their first tumor removal. About 196 adults with non-muscle-invasive bladder cancer will be randomly assigned to have their repeat surgery decisi…

This study is testing whether a simple urine test that looks for cancer DNA can help decide when patients with high-risk bladder cancer need a cystoscopy (a camera exam of the bladder). Cystoscopy is effective but uncomfortable and can cause infections. The goal is to safely redu…

This study tests a new type of ultrasound called Super-Resolution Ultrasound Localization Microscopy to see if it can better detect bladder cancer before surgery. Thirty patients scheduled for bladder removal will receive this ultrasound while under anesthesia. The results will b…

This study tests whether a simple urine test (Bladder EpiCheck) can safely replace some of the invasive cystoscopy procedures used to monitor non-muscle invasive bladder cancer. About 240 adults with low-grade intermediate-risk bladder cancer will be followed to compare quality o…

This study is testing whether a special MRI scan (mpMRI) can accurately diagnose muscle-invasive bladder cancer without needing an invasive biopsy (TURBT). Researchers will compare the MRI results to the biopsy results in 30 adults with suspected muscle-invasive bladder cancer. I…

This study is testing whether regular urine tests every 6 months can find bladder cancer earlier in people at high risk, such as smokers over 50 and those with long-term workplace chemical exposure. Researchers will enroll 1,000 participants and track how many cancers are detecte…

This pilot study is testing whether a special PET/CT scan using 68Gallium PSMA can find cancer that has spread in people with metastatic bladder cancer or melanoma. Twenty participants will receive both the standard FDG-PET/CT scan and the new 68Ga PSMA-PET/CT scan within 10 days…

This study is testing BCDx, a urine-based test designed to detect the return of non-muscle invasive bladder cancer (NMIBC) earlier and without a scope. Researchers will enroll 500 people with a history of NMIBC and compare the test's accuracy to standard cystoscopy. If it works, …

This study tests a new device called the Glean Urodynamics System, which uses sensors and an app to monitor bladder function both in the clinic and at home. It includes 101 adults with bladder issues like overactive bladder or incontinence. The goal is to see if the device is saf…

This study is testing a new, non-invasive urine test that looks for a protein called CREPT in cells shed from the bladder. The goal is to see if this test can accurately detect bladder cancer and monitor if it comes back after treatment, potentially replacing uncomfortable and in…

This study tests a new ultrasound method to measure bladder function without invasive procedures. Researchers at Mayo Clinic will compare the new technique to standard tests in adults with bladder issues or enlarged prostate. The goal is to see if this painless approach can accur…

This study looks at whether the things people buy at stores—like pain relievers or digestive aids—could be early warning signs of cancer. Researchers will compare the shopping habits of 2900 people, some diagnosed with cancer and some not, to see if certain purchases happen more …

This study looks at whether a simple urine test can detect leftover cancer after initial surgery for high-risk bladder cancer. The goal is to help doctors decide who truly needs a second surgery, avoiding unnecessary procedures and their risks. About 60 adults with high-risk non-…

This study is testing a new liquid biopsy that uses blood and urine samples to help diagnose, monitor treatment, and predict recurrence in people with urothelial carcinoma (a type of bladder cancer). Researchers will enroll 300 participants and compare the liquid biopsy results w…

This study is developing a new DNA test that looks for key genetic changes in bladder cancer tumors. Researchers will collect tumor samples from 400 patients to build and validate the test. The goal is to create a cost-effective tool that helps doctors predict which patients are …

This study is testing a new platform that uses advanced testing to get a complete picture of a person's tumor. The goal is to see if this detailed information can help doctors choose better treatments for patients with high-risk cancers like leukemia, multiple myeloma, and pancre…

This study is testing a new urine test that aims to predict whether bladder cancer patients will respond well to a standard treatment called BCG. Currently, about half of patients do not respond to BCG, leading to extra treatments or bladder removal. The test looks for specific m…

This study is testing a new urine test that looks for specific proteins to detect bladder cancer in people who have microscopic blood in their urine (not visible to the naked eye). The goal is to see if this simple, non-invasive test can accurately identify cancer, potentially re…

This study is testing a new urine test that might find returning bladder cancer earlier and more accurately than current urine tests. The goal is to see if this test can reduce the need for cystoscopy, a procedure where a tiny camera is inserted into the bladder. About 300 adults…

This study tests an online screening tool (website or app) to help people with frequent urination get diagnosed with overactive bladder earlier. About 1,000 adults who often need to urinate more than 7 times a day will use the tool and then see a specialist to confirm the diagnos…

This study is testing a new urine test called Bladder EpiCheck to see how well it can detect bladder cancer in people aged 45 and older who have blood in their urine. Researchers will compare the test results to standard cystoscopy (a camera exam of the bladder). The goal is to f…

This study is testing a blood test that looks for DNA signals from 20 different cancers, including lung, breast, and colon cancer. Researchers will see if the test can find cancer early, detect any cancer left after treatment, and catch a relapse before it shows up on scans. The …

This study is testing whether specially trained dogs can detect bladder cancer by smelling urine samples. Researchers will collect urine from 340 adults scheduled for bladder surgery and see how often the dogs correctly identify cancer. If it works, this could lead to a simple, n…

This study compares a new diagnostic approach—using an MRI plus a same-day biopsy—against the standard procedure (TURBT) for diagnosing muscle-invasive bladder cancer. Researchers will enroll 360 adults suspected of having this aggressive cancer. The goal is to see if the new met…

This registry study is gathering information on how well blue light cystoscopy with Cysview detects bladder cancer compared to standard white light cystoscopy. About 4400 adults with suspected or known non-muscle invasive bladder cancer will take part. The goal is to see if the b…

This early-phase study tests a new MRI technique that uses two contrast agents (gadobutrol and ferumoxytol) placed directly into the bladder to improve staging of bladder cancer. Researchers will compare MRI images to actual tumor samples from surgery to see if the scan can accur…

This study is looking at whether analyzing DNA and proteins in urine can help detect cancers of the bladder and kidney without invasive procedures. Researchers will collect urine samples from 500 adults, including those with known or suspected cancer and healthy volunteers. The g…

This study looks at whether taking PET scans later (2.5 hours after injection) finds lymph node spread in muscle-invasive bladder cancer more accurately than standard scans (1 hour after). About 66 adults with this cancer will get both scans, and results will be compared to surgi…

This study is testing a simple urine test called CxBladder to see if it can accurately detect when bladder cancer comes back. Currently, patients need a camera inserted into the bladder (cystoscopy) for monitoring, which is uncomfortable and costly. The study will collect urine s…

This study is testing whether a combined blood and urine DNA test can accurately detect muscle-invasive bladder cancer in patients scheduled for bladder removal surgery. Researchers will compare the test results with the actual findings from surgery. The goal is to see if this no…

This study looks at whether adding a human amniotic membrane graft to standard mesh surgery can lower the risk of mesh exposure, a common complication. About 330 women with pelvic organ prolapse or stress urinary incontinence will take part. The goal is to see if the membrane hel…

This study is testing whether dutasteride, a pill already used for prostate issues, can stop low-grade bladder cancer from coming back. About 95 adults with this type of bladder cancer will take the drug daily. The goal is to see if it reduces the need for repeated surgeries and …

This study tests whether moxibustion, a traditional therapy that burns herbs near the skin, can prevent hemorrhagic cystitis (painful bladder inflammation) in 266 patients receiving stem cell transplants. Participants are randomly assigned to receive either standard care or stand…

This study tests whether gentle electrical stimulation of nerves in the leg or lower back can prevent the bladder from becoming overactive after a spinal cord injury. Researchers will compare two types of nerve stimulation against standard care in 45 adults who had a spinal injur…

This study tests whether cancer patients can complete a supervised exercise program from home using video calls. The program includes resistance training with dumbbells and aerobic exercise. Researchers want to see if this approach is practical and helps patients maintain functio…

This study tests whether taking zinc supplements before a Botox injection can improve results for women with overactive bladder. 72 women will receive either zinc or a placebo pill for five days before their Botox treatment. Researchers will track how many need another injection …

This study tests a medical device (a perineal probe connected to a mobile app) for women with stress urinary incontinence. Participants use the device at home for 15 minutes, three times a week, plus two sessions with a physiotherapist. The goal is to see if this approach works a…

This study tests whether a once-daily pill called orforglipron can reduce stress urinary incontinence (leaking urine during movement) in women with obesity or overweight. About 1000 adult women will receive either the drug or a placebo for about 58 weeks. The main goal is to see …

This study is testing a new external device (Axonics ETS-02) to see if it is safe and works for people with overactive bladder or fecal incontinence. About 75 adults will wear the device for a short trial period. The goal is to check if the device stays attached and works properl…

This study tests a device called the Axonics SNM System, which uses mild electrical pulses to calm the nerves that control the bladder. It is for men with overactive bladder, including those with urgency incontinence or frequent urination. The trial will enroll 150 men and track …

This study looks at whether adding a small drainage tube in the belly during surgery for large bladder stones (over 2 cm) can make the operation faster and easier. About 140 adults will be randomly assigned to get the standard procedure alone or with the extra tube. The main goal…

This study tests a navigation program for cancer patients starting immunotherapy. The program helps with essential needs like food, transportation, and housing, and tracks side effects. Researchers want to see if this support helps patients continue their treatment and improves t…

This study tests whether a shared decision-making tool can help pharmacists and patients better understand when antibiotics are truly needed for uncomplicated cystitis (bladder infection). About 506 women with symptoms will be enrolled. The goal is to reduce unnecessary antibioti…

This study tests whether adding hip abductor exercises to standard pelvic floor training can reduce urine leaks in women with stress urinary incontinence. About 78 women will be split into two groups: one does only pelvic floor exercises, the other adds hip exercises at home. The…

This study tests two medications, mirabegron and tamsulosin, to see which works best for helping people pass ureteral stones and reducing pain. 500 adults with stones between 4-10 mm will be randomly assigned to one of four groups: mirabegron alone, tamsulosin alone, both drugs t…

This study compares two types of core exercises—hypopressive training and transversus abdominis focused training—to see which better reduces urinary incontinence and improves pelvic floor function and quality of life in women after childbirth. Sixty women who had a normal vaginal…

This study looks at whether a combination of two drugs (solifenacin and mirabegron) at low doses works better than a high dose of either drug alone for children aged 5 to 14 with daytime wetting. About 236 children who did not fully respond to low-dose single drugs will be random…

This study compares giving the cancer drug nivolumab (Opdivo) as a shot at home versus in a clinic for people with various advanced cancers. The goal is to see if home treatment improves patients' overall care experience and quality of life. About 50 adults will receive the drug …

This study tests two different ways of positioning patients during surgery for stones in the upper part of the ureter. One position uses a slight head-down tilt to keep stones from moving back into the kidney, while the other tilts the patient to help clear stones from the kidney…

This study compares two types of exercises—hypopressive exercises and the Paula method—to see which better helps postpartum women with urinary incontinence. Sixty women who had a vaginal delivery and leak urine at least once a week will do one of the two exercises twice a week fo…

This study compares three different surgical techniques for men with very large prostates (over 100 mL) who have severe urinary symptoms. Ninety men will be randomly assigned to receive either thulium fiber laser, holmium laser, or bipolar electrosurgery. Researchers will measure…

This study tests whether injecting Botox into the bladder wall during a standard prostate surgery (HoLEP) can better control overactive bladder symptoms like sudden urges to urinate and leakage. About 66 men aged 18-89 with these symptoms will be randomly assigned to get Botox or…

This study compares a new type of ureteral stent (ComfiJ) with a standard Double-J stent in 150 adults who need a short-term stent after kidney stone surgery. The goal is to see if the ComfiJ stent causes fewer urinary symptoms, like pain or urgency, two weeks after surgery. Part…

This study compares two surgical techniques for removing bladder stones in children aged 2 to 14 years. One method uses a small cut in the belly area with a vacuum to remove stone fragments, while the other uses a scope through the urethra. The goal is to see which approach is fa…

This study compares two procedures—a sling or a bulkamide injection—to treat stress urinary incontinence in women who are also having vaginal prolapse repair. About 476 participants will be randomly assigned to one of the two treatments and followed for 24 months. The goal is to …

This study tests whether putting a drug called aminophylline into the bladder before placing a ureteral stent helps doctors get the stent past a blocking stone more easily. The trial involves 72 adults with sudden kidney failure from stones in a single working kidney. Half get th…

This study compares L-citrulline, an amino acid, to tamsulosin, a standard drug, for helping adults pass kidney stones. 120 people with a single stone in the lower ureter will take one of the two treatments for up to 4 weeks. The main goal is to see which treatment leads to faste…

This study tests if a drug called aminophylline, placed directly into the bladder, can help doctors insert a small scope to remove kidney stones in children. About 60 children aged 2 to 17 with a stone in the lower ureter will take part. If the first gentle attempt to pass the sc…

This study tests whether a simple breathing exercise called the 4-7-8 technique can help people sleep better, feel less pain, and recover faster after bladder surgery. About 68 adults having this surgery will be randomly assigned to either learn the breathing exercise or receive …

This study compares two ways to use a laser to break up bladder stones in children: dusting (turning stones into fine dust) and fragmentation (breaking them into small pieces for removal). About 110 children with a single stone smaller than 3 cm will be randomly assigned to one m…

This study compares melatonin, solifenacin, and their combination to reduce bothersome urinary symptoms and pain caused by a temporary ureteral stent placed after kidney stone surgery. About 189 adults will take one of the two drugs or both for 14 days. The goal is to see which a…

This study compares a nasal spray form of ketorolac (Sprix) to oral diclofenac pills for managing pain from ureteral stents placed after kidney stone surgery. Researchers will enroll 80 adults to see if the nasal spray provides faster pain relief and reduces unplanned doctor visi…

This study compares a mobile app-guided pelvic floor exercise program to standard in-person rehabilitation for women with stress or mixed urinary incontinence. Thirty-two adult women will follow either the app or in-person sessions for 3 months. Researchers will measure changes i…

This study tests whether a high-protein nutrition plan combined with resistance exercises, started weeks before surgery and continued for 24 weeks after, can help older adults with cancer preserve their physical function. The trial enrolls Veterans aged 55 and older with certain …

This study compares giving cancer treatment at home versus in a clinic for 27 adults with various cancers in the Florida Panhandle. The goal is to see if home treatment is preferred and improves satisfaction, while also checking safety. Participants will receive their usual cance…

This early study tests a new implantable device that senses bladder nerve signals and delivers stimulation to reduce sudden urges to urinate. Ten women with overactive bladder that hasn't improved with standard treatments will receive the device. The goal is to see if the device …

This study tests whether a non-invasive nerve stimulation device placed on the ankle can reduce bladder symptoms like urgency and frequent urination in people with multiple sclerosis. 72 participants will be randomly assigned to receive either real or sham stimulation over severa…

This study tests whether a small electrical device (TENS) can reduce pain for women undergoing an in-office procedure for stress urinary incontinence. About 100 women will be randomly assigned to receive either real TENS or a placebo device during the procedure. The goal is to se…

This study tests two types of gentle stimulation—magnetic or electrical—applied over the lower back to help control bladder overactivity in people with spinal cord injury. Forty adults aged 18-65 who still have bladder leaks despite medication will receive 20 sessions over four w…

This study tests a 12-week pelvic floor exercise program for women aged 65 and older living in nursing homes who have stress urinary incontinence (leakage with coughing, sneezing, or movement). One group will do standard exercises while watching and imagining themed videos to imp…

This study is testing whether a low-frequency pulsed electromagnetic field (PEMF) device can safely reduce pelvic pain and urinary symptoms in women with Interstitial Cystitis/Bladder Pain Syndrome. About 75 female adults will use the device at home, and researchers will track th…

This study looks at whether combining Paula exercises (a type of pelvic floor training) with tibial nerve stimulation (a non-invasive nerve treatment) can help women with stress urinary incontinence. The goal is to reduce leakage, strengthen pelvic muscles, improve sexual functio…

This study tests a special sock called the ZIDA Control Sock that gives mild electrical pulses near the ankle to help people with overactive bladder who still have leaks despite taking medicine. About 20 adults will use the sock at home once a week for 12 weeks while staying on t…

This study tests whether low-energy shock wave therapy, a non-invasive treatment, can improve overactive bladder symptoms in women who also have metabolic syndrome. Sixty women will receive either the real therapy or a sham procedure. Researchers will track symptom changes using …

This study tests whether combining tamsulosin with either a standard or half dose of tadalafil can better relieve symptoms caused by ureteric stents, such as pain, urgency, and discomfort. Researchers will enroll 140 adults who have a stent placed after kidney stone removal. The …

This study tests whether delivering tiny electrical bursts to a nerve bundle in the lower back can reduce pain in women with bladder pain syndrome. Five women will receive the procedure once and be followed for six months. Researchers will measure pain, bladder symptoms, mood, an…

This study looks at whether walking 8,000 to 10,000 steps each day for four weeks before bladder cancer removal surgery can lower the chance of problems after the operation. About 146 adults with bladder cancer who are scheduled for surgery will take part. Half will be asked to i…

This study is testing whether taking pumpkin seed oil extract can improve bladder function in people with overactive bladder. Researchers will ask 40 participants to take the supplement for 12 weeks and track their symptoms using surveys. The goal is to see if this natural option…

This study compares giving cancer treatment at home versus in the clinic for people with advanced cancers. The goal is to see if home treatment reduces stress, financial burden, and improves overall experience. About 220 participants will be randomly assigned to receive their reg…

This study tests a device that sends mild electrical pulses to the pelvic floor muscles to help men who have bladder leakage after prostate cancer treatment. About 41 men with moderate leakage for at least 6 months will use the device at home for 20 minutes a day, 5 days a week, …

This study tests whether combining Swiss ball exercises with diaphragmatic breathing can reduce stress urinary incontinence (leaking urine when coughing, sneezing, or exercising) in pregnant women. Forty-two pregnant women with mild to moderate incontinence will be split into two…

This study tests whether giving chemotherapy directly into the bladder at home is safe and acceptable for people with non-muscle invasive bladder cancer. About 40 participants will receive their usual medications—such as BCG, gemcitabine, docetaxel, or mitomycin—at home instead o…

This study tests a new hormone-free gel for women with genitourinary syndrome of menopause (GSM), which causes vaginal dryness, pain, and other symptoms. About 80 postmenopausal women will use the gel for 8 weeks. Researchers will measure changes in quality of life using a questi…

This study compares a new radiation technique called lattice radiation therapy (LRT) to standard stereotactic body radiation therapy (SBRT) for people with solid tumors that have spread to soft tissues. The goal is to see if LRT shrinks tumors better and helps the immune system f…

This study looks at 56 adults with non-muscle-invasive bladder cancer who receive BCG therapy, a standard treatment that often causes painful bladder symptoms. Researchers want to see if giving Blad-Care (a gel that restores the bladder's protective lining) early during BCG treat…

This study tests whether adding breathing training to standard pelvic floor therapy helps new moms with stress urinary incontinence (leaking urine when coughing, sneezing, or exercising). About 58 women who are 6 weeks to 6 months postpartum will either get standard care or stand…

This study compares two home exercise programs for women with stress urinary incontinence (leakage during coughing, sneezing, or exercise). One program focuses on pelvic floor muscles, the other on core stabilization. Fifty-one women will participate in a 12-week program, and res…

This study tests a non-invasive brain stimulation technique called rTMS to improve bladder symptoms in women with multiple sclerosis. Participants receive either real or sham treatment over 10 sessions. The goal is to see if targeting specific brain areas can reduce urinary urgen…

This study tests a program of exercise, protein drinks, and mind-body activities like yoga for people aged 65 and older with advanced ovarian or pancreatic cancer. The goal is to see if patients can stick with the program while on chemotherapy before surgery. The study is small, …

This study tests whether letting a bladder catheter fall out on its own (passive removal) is better than having a nurse pull it out (active removal) after urological surgery. 160 men will be randomly assigned to one method. Researchers will measure satisfaction, pain, and anxiety…

This study compares a home-based physical activity program delivered through the ExerciseRx app to health education alone in 100 adults with non-muscle invasive bladder cancer. Participants will use a Fitbit to track steps, and the app will set personalized goals and provide enco…

This study tests a new flexible suction sheath (FANS) against the traditional sheath for kidney stone removal surgery. About 80 adults with small-to-medium kidney stones will be randomly assigned to one of the two tools. The main goal is to see which tool leaves fewer stone fragm…

This study looks at whether a single injection of the antibiotic amikacin can effectively treat uncomplicated bladder infections in women visiting the emergency department. Instead of taking pills for several days, participants receive one shot into a muscle or vein. The goal is …

This study tests a small implanted device that stimulates a nerve in the lower back to help control sudden, urgent urination. Thirty adults who have not been helped by standard medications will use the device for 30 minutes each day. Researchers will check if it reduces leaking e…

This study tests a telehealth program for cancer survivors with an ostomy (a surgical opening in the belly to pass waste). The program includes group sessions led by nurses and peer ostomates to teach self-management skills. Researchers will enroll 150 patients with colorectal or…

This study compares two X-ray settings during a procedure to treat overactive bladder. The goal is to see if a new setting reduces radiation exposure while still placing the device correctly. About 44 adults with overactive bladder will take part. The results could make this comm…

This study looks at whether doing simple exercises at home before bladder or upper tract cancer surgery can help patients feel stronger and recover faster. About 128 adults scheduled for surgery will either receive a personalized home exercise plan via a smartphone app or standar…

This study tests a new device designed to help women with stress urinary incontinence—leaking urine when coughing, sneezing, or exercising. The trial will compare the real device to a sham (fake) device in 96 women over 12 weeks. The main goal is to see if the device reduces urin…

This study compares two ways of doing a common surgery for pelvic organ prolapse and stress incontinence. Doctors want to know if placing a small mesh sling before or after lifting the vagina leads to better bladder control and happier patients. About 110 women having robotic sur…

This study compares a newer exercise method called Dynamic Neuromuscular Stabilization (DNS) to standard pelvic floor muscle training for women with stress urinary incontinence (leaking urine when coughing, sneezing, or exercising). About 62 women will be randomly assigned to one…

This early study tests a device called UCon, which is placed on the skin to send mild electrical pulses to nerves that control the bladder and bowel. The goal is to reduce symptoms like sudden urges, leaks, and frequent bathroom trips in women with overactive bladder or bowel dys…

This study compares two medicines—tadalafil (a drug often used for erectile dysfunction) and solifenacin (a standard OAB treatment)—to see which works better for women with overactive bladder. About 480 women in Egypt will take one pill daily for 12 weeks. Researchers will track …

This study looks at whether placing a small tube (stent) in the urinary tract after bladder removal surgery affects recovery. About 70 adults with bladder or pelvic cancers will be randomly assigned to get a stent or not. The main goal is to see if avoiding stents lowers the risk…

This study looks at whether a 3-day trial of a nerve-stimulating device for bladder control works as well as the standard 7-day trial. About 193 women with urgent or frequent urination will be randomly assigned to either a 3-day or 7-day test. The goal is to see if the shorter tr…

This Phase 3 trial tests whether a single spinal injection of morphine and bupivacaine before robotic kidney or ureter surgery leads to better recovery than an intravenous lidocaine drip during surgery. About 220 adults scheduled for robotic upper urinary tract surgery will be ra…

This study tests whether adding Hydeal Cyst® instillations can reduce lower urinary tract symptoms in people receiving standard chemotherapy or immunotherapy for non-muscle invasive bladder cancer. About 200 participants will receive either BCG or MMC, and half will also get Hyde…

This study tests a newer type of radiation therapy that adjusts to daily changes in a patient's body shape. The goal is to safely use smaller treatment areas to reduce side effects like bladder and bowel problems. About 280 adults with pelvic cancers (prostate, bladder, rectal, a…

This study tests a non-implanted electrical stimulation device for women with overactive bladder (OAB). About 151 participants will use the device or take medication to see if the device safely reduces daily bathroom trips. The goal is to offer a non-surgical option for symptom r…

This study tests a program called CARES that provides nurse navigators and counselors to rural cancer patients. The goal is to see if this support helps patients start and finish treatment more quickly and improves their quality of care. About 320 adults with solid tumors like lu…

This study tests whether taking the steroid prednisone after ureteroscopy (a surgery for kidney stones) can help reduce pain and the need for other pain medications. Researchers will enroll 90 adults who are having this surgery with a stent placed. The goal is to see if adding a …

This study looks at whether yoga can improve overactive bladder symptoms in children aged 8 to 18. Participants attend a weekly yoga session for 6 weeks. Researchers will track symptom changes using questionnaires and urine tests. The goal is to find a gentle, non-drug option for…

This study tests a device that uses radiofrequency energy inside the vagina to treat overactive bladder in women. It includes 202 women aged 22 to 80 who have had symptoms for at least 6 months. Half will get the real treatment and half a sham (fake) treatment to see if the devic…

This study tests whether a skin patch that delivers oxybutynin works better than oral pills to reduce bladder pain and urgency in children after bladder surgery. About 100 children aged 4 to 8 will be enrolled. The goal is to see if the patch provides better relief and reduces th…

This trial tests a special education and navigation program for people with advanced bladder cancer and their caregivers. The program provides guidance, nutritional advice, and distress screening to help them better manage treatment decisions and care coordination. Researchers ho…

This study tests a brief, 4-session cognitive behavioral therapy (CBT) program for people with urologic chronic pelvic pain syndrome (UCPPS), including interstitial cystitis and chronic prostatitis. The treatment is mostly home-based with minimal therapist contact, teaching skill…

This study tests if electrical stimulation applied to the vaginal area or the perineum (the area between the vagina and anus) can help women with overactive bladder. 63 women will be split into three groups: one gets vaginal stimulation plus bladder training, another gets perinea…

This study looks at whether women with overactive bladder can remove a temporary nerve testing lead at home instead of coming back to the doctor's office. The lead is placed during a short procedure to see if a permanent nerve stimulator might help. Researchers want to know if wo…

This study looks at whether people with different types of bladder pain respond better to different treatments. About 220 adults with interstitial cystitis/bladder pain syndrome will receive either pelvic floor physical therapy or cognitive-behavioral therapy. The goal is to see …

This study tests a single dose of VNX001, a mix of lidocaine and heparin, to quickly reduce moderate to severe bladder pain in people with interstitial cystitis/bladder pain syndrome. About 120 adults with a history of IC/BPS for at least 9 months will receive either VNX001, plac…

This study tests a drug called VNX001 for people with Interstitial Cystitis (a painful bladder condition) who have sudden, moderate-to-severe bladder pain. About 50 adults will receive up to 6 doses of the drug directly into the bladder over 14 days. The goal is to see if the dru…

This study tests whether adding acupuncture to standard behavioral changes can better relieve bladder pain in women with interstitial cystitis. Thirty-four women who have not had prior treatments will receive either behavioral management alone or behavioral management plus weekly…

This study tests the ApricityCare program, which helps people with metastatic cancer and their doctors spot treatment side effects early. The goal is to manage these side effects quickly so patients can stay on their cancer therapy longer. About 425 adults starting systemic cance…

This study tests whether light therapy and occupational therapy can reduce fatigue in people with genitourinary cancers (like prostate, kidney, or bladder cancer). About 224 adults on active cancer treatment will be assigned to receive light therapy, occupational therapy, both, o…

This study looks at whether leaving a stent out after kidney stone surgery can reduce pain and the need for extra medical visits. About 184 adults with kidney or ureteral stones will be randomly assigned to either get a stent or not after their procedure. Researchers will track p…

This study compares two surgeries for stress urinary incontinence (leaking urine when coughing or sneezing) in women. One method uses a synthetic mesh sling, while the other repairs natural tissues without mesh. Researchers will track symptom improvement, recovery time, pain, and…

This study looks at whether it is safe and less painful to skip placing a temporary tube (stent) after routine kidney stone removal. About 792 adults with small stones will either get a stent or not, and researchers will track pain and any unplanned doctor visits. The goal is to …

This study tests whether a chair that uses electromagnetic pulses to strengthen pelvic floor muscles can help people with overactive bladder. About 166 adults who have not gotten relief from lifestyle changes or medications will sit in the chair twice a week for four weeks. Half …

This study tests a chair called Emsella that uses electromagnetic energy to treat stress urinary incontinence—leaking urine when coughing, sneezing, or exercising. About 110 adults aged 18 to 80 will sit in either the real chair or a fake (sham) chair to see if it reduces leaks b…

This study tests a personalized 6-month program for older adults being treated for bladder or kidney cancer. The program includes exercise sessions and educational workshops before and after surgery. The goal is to see if it can reduce frailty, measured by how far patients can wa…

This study tests a short self-help booklet designed for people recently diagnosed with certain cancers (breast, colorectal, gynecological, melanoma, or bladder) who still smoke. The goal is to see if the booklet is easy to use and helps increase their motivation to quit. About 10…

This study compares two minimally invasive procedures—semi-rigid and flexible ureteroscopy—for removing upper ureter stones smaller than 2 cm. Researchers will measure which method clears stones more effectively, how long the surgery takes, and overall costs. The trial enrolls 10…

This study tests whether a Chinese herbal medicine formula called S-2196 can safely reduce urine leakage in women aged 55 and older with stress urinary incontinence. Fifteen participants will take the herbal formula for 2 weeks, and researchers will measure changes in leakage amo…

This study compares two surgical approaches for removing the bladder in men with bladder cancer: prostate capsule-sparing and nerve-sparing. The goal is to see which technique better preserves erectile function and urinary control. Seventy men will be randomly assigned to one of …

This study compares two treatments for children with overactive bladder (OAB) of unknown cause: the standard medication oxybutynin and a nerve stimulation therapy (PTNS). About 124 children aged 6 to 16 will be randomly assigned to one treatment for three months. The goal is to s…

This study looks at whether daily text message reminders to do pelvic floor exercises can help men recover bladder control faster after prostate surgery. About 132 men who are planning to have prostate surgery will be split into two groups: one gets the text reminders, the other …

This study collects blood and tissue samples from 2000 people—some with cancer and some without—to create a blinded reference set. Researchers will use these samples to evaluate how well new blood tests can detect many types of cancer early. The goal is to improve the accuracy of…

This study collects blood, urine, saliva, and tissue samples from nearly 6,000 people who have or may have cancer, including rare inherited forms. The samples are stored and used for research to understand the genetic and molecular basis of cancer. No new treatment is being teste…

This study is building a huge registry of information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. Researchers will use this resource to study what causes cancer and how to better prevent, detect, and treat it. The re…

This study is collecting live tumor samples from 2,000 cancer patients undergoing standard biopsies. Researchers will analyze these samples to understand how tumors respond to immunotherapy drugs outside the body. The goal is to develop a method to predict which patients will res…

This study looks at two common treatments for a type of bladder cancer that keeps coming back: treatments that keep the bladder (like medicine placed directly into the bladder) versus surgery to remove the bladder. The goal is to see which option is better for patients' wallets, …

This study is observing how bladder cancer is treated in Russia and how common certain markers (HER2 and PD-L1) are in different stages. Researchers will look at medical records of 600 people with bladder cancer to see what treatments they receive and how the disease progresses. …

This study is a long-term registry that will follow 1,000 women who receive pelvic mesh products for stress urinary incontinence or pelvic organ prolapse. Researchers will track how well the mesh works and any complications over 5 to 10 years. The goal is to gather real-world dat…

This study tests a redesigned surgical tool for removing bladder tumors. Researchers will use the device on bladder specimens from 25 patients who need their bladder removed. The goal is to see if the modified device provides better tissue samples for pathology, helping doctors a…

This study tracks 770 adults with advanced solid cancers (like lung, head and neck, melanoma, or bladder cancer) who are receiving immunotherapy. Researchers collect tumor and blood samples over time to find biological markers that predict how well the treatment works or causes s…

This study looks at how other medical conditions (comorbidities) affect recovery and survival in 500 bladder cancer patients after bladder removal surgery. Researchers will use artificial intelligence to analyze patient data and find patterns that could help doctors make better t…

This study aims to find out if chronic pelvic pain conditions like prostatitis and interstitial cystitis can be inherited. Researchers will collect DNA and urine from 500 participants, including family members, to look for genetic links. The goal is to better understand the cause…

This study screens adults with certain cancers (like melanoma, lung, or colorectal cancer) to see if they qualify for experimental treatments being tested by the NCI Surgery Branch. These treatments involve taking a patient's own immune cells, growing them in a lab, and giving th…

This study is looking for factors that might predict inflammatory polyps in the ureter (the tube from kidney to bladder) in people with kidney stones. Researchers will review past patient data and then test their predictions on new patients. The goal is to create a simple tool th…

This study follows 1,100 adults with rare urinary tract cancers, such as unusual bladder, kidney, testicular, or penile cancers. Researchers will collect medical records, blood and tumor samples, and imaging over many years to understand how these cancers grow and respond to trea…

This early-stage trial is testing whether bicalutamide, a drug typically used for prostate cancer, can change a protein linked to bladder cancer growth. Researchers will compare men with non-muscle invasive bladder cancer who take the drug to those who don't. The goal is to see i…

This study follows 1,000 adults who have long-term bladder or bowel problems from past cancer radiation and are receiving hyperbaric oxygen therapy (HBOT). Researchers want to learn which patients improve most and when treatment works best. The goal is to better understand how to…

This large observational study will follow 4,000 adults undergoing percutaneous nephrolithotomy (PCNL) for kidney stones across many international centers. Researchers will track which surgical techniques are used, how well they clear stones, and what complications occur. The goa…

This study looks at how the drug enfortumab vedotin affects nerves in people with advanced or muscle-invasive bladder cancer. Researchers will use nerve tests and patient surveys to track changes over 9-15 weeks. The goal is to better understand and potentially reduce nerve damag…

This study looks at whether certain bacteria or viruses in the bladder might be linked to bladder cancer. Researchers will compare the germs found in cancerous bladder tissue with those in healthy tissue from the same person. The goal is to see if there are differences that could…

This study looks at men with urinary retention who need a catheter before having prostate laser surgery (HoLEP, ThuLEP, or ThuFLEP). Researchers want to see if the length of time with a catheter affects how well the surgery works. They will measure changes in urinary symptoms, fl…

This study looks at why some women develop stress urinary incontinence (leaking urine when coughing or sneezing) after surgery for pelvic organ prolapse. Researchers will follow 382 women who have no incontinence before surgery, using phone calls and questionnaires at 3, 6, and 1…

This study is looking at whether tiny bits of tumor DNA (ctDNA) found in blood or urine can help doctors better understand and predict the course of a high-risk type of bladder cancer called T1G3. About 35 adults with this cancer will provide samples before, during, and after tre…

This study explores whether giving BCG therapy for non-muscle invasive bladder cancer at home is feasible and effective. It includes two groups: one to understand barriers to treatment compliance, and another to test a home BCG program with a chatbot that tracks symptoms and qual…

This study is for 150 adults having surgery for bladder cancer. Researchers want to see if the amount of fluid absorbed during surgery and changes in DNA in the blood can help predict if the cancer will return or get worse. The goal is to improve how doctors assess risk and plan …

This study aims to validate a gene test that identifies oxygen-starved (hypoxic) tumours in bladder and prostate cancer patients. About 30 participants will provide tumour samples and blood, and some will have MRI scans. The goal is to see if this test can help doctors choose mor…

This study looks at 30 women who have had surgery for stress urinary incontinence before but still have symptoms. Researchers want to see if using a special test (urodynamics or video-urodynamics) before another surgery helps improve results. The goal is to find out which test is…

This study is testing a software tool that uses DNA from a blood sample to predict the risk of blood clots returning in people with cancer who have finished 3-12 months of blood thinner treatment. The goal is to see if a low-risk result means it's safe to stop blood thinners with…

This study aims to understand how sacral neuromodulation (a nerve-stimulating device) changes the autonomic nervous system in people with overactive bladder. Researchers will measure heart rate variability in 40 adults during the device implantation procedure. The goal is to find…

This study looks at how long a person has been on dialysis and how much urine they still make affects bladder size and flexibility. Researchers will measure bladder function in 87 adults with kidney failure who are waiting for a transplant. The goal is to find bladder problems ea…

This study is a registry that collects information on how doctors treat and monitor patients with non-muscle-invasive bladder cancer in France. Researchers will track up to 8,000 adults to see how often cancer returns or worsens, and to test the accuracy of urine biomarker tests.…

This study looks at how certain drugs that affect the body's endocannabinoid system (similar to cannabis) change the way bladder muscle contracts. Researchers will take a small piece of healthy-looking bladder tissue from 65 adults having bladder cancer surgery. They will test th…

This study looks at brain activity in children with overactive bladder and daytime wetting compared to healthy children. Researchers use MRI scans to see if brain areas that control the bladder work differently. They also test if a gentle nerve stimulation treatment (TENS) change…

This study looks at whether the position a person is in during a urodynamic exam (a test that measures bladder function) affects the diagnosis of an overactive bladder in people with multiple sclerosis or Parkinson's disease. Researchers will compare results from tests done while…

This study looks at the bacteria found in urine, the genital area, and stool of children with overactive bladder and daytime wetting, comparing them to healthy children. Researchers want to see if these bacteria differ between the groups and if they change with treatment or as ki…

This study is creating a large database of how patients recover after bladder cancer surgery (radical cystectomy). Researchers at MD Anderson and other centers will collect information from patients and doctors about symptoms and recovery. The goal is to understand what helps peo…

This study looks at gut bacteria diversity in children aged 1 to 3 who take long-term antibiotics for a condition called vesicoureteral reflux (urine flowing backward into the kidneys). Researchers will compare their gut bacteria to two other groups: children with the same condit…

This study looks at whether limiting food intake to an 8-hour window each day can improve sleep, physical activity, and reduce sitting time in college-aged women. Thirty-six female students at the University of Georgia will either follow this eating pattern or receive basic nutri…

This study looks at whether repeated sessions of hyperbaric oxygen therapy (HBOT) can damage DNA in people who have had radiation for cancer. HBOT is used to help heal tissues damaged by radiation, but it also creates reactive oxygen molecules that might harm DNA. Researchers wil…

This study collects urine samples from 1000 adults who may have bladder cancer or are being monitored for it. Researchers will use the samples to improve a test called Bladder EpiCheck. Participants provide one urine sample and share basic health information. The goal is to make …

This study collects blood, urine, saliva, and tumor tissue from 500 adults with urothelial cancer (bladder, ureter, or urethra) and healthy volunteers. Researchers will analyze the samples to find genetic differences between normal and cancer cells. The goal is to better understa…

This study from the University of Zurich is looking at how tiny organisms (microbes) and the immune system interact in the bladder. Researchers will collect samples from 800 adults with various urinary conditions, including infections, bladder pain, and overactive bladder, as wel…

This study tracks how bladder cancer treatment affects patients' energy needs and muscle function. Researchers will measure resting energy use and collect blood samples from 30 patients before and after chemotherapy and surgery. The goal is to learn more about these changes so fu…

This study collects tumor, blood, urine, and stool samples from 1000 adults with suspected or confirmed bladder cancer. The samples are stored securely for future biological and genetic research. The goal is to build a resource that can help scientists better understand the disea…

This study from Mayo Clinic is collecting blood and urine samples from 1,500 people with bladder cancer. The goal is to use these samples to develop simple, non-invasive tests that could detect bladder cancer earlier. Participants provide samples once, and no experimental treatme…

This study is testing whether a simple rectal mucus sample can detect DNA changes linked to lung, pancreatic, bladder, and colorectal cancers. Researchers will collect samples from 450 adults using a special device and analyze them for genetic and epigenetic markers. The goal is …

This study tests whether a patient's position (lying down, sitting up, or moving freely) affects how long the BCG medicine stays in the bladder during treatment for non-muscle invasive bladder cancer. Researchers will measure dwell time in 40 patients under three different positi…

This study collects tissue samples from people with various advanced or early-stage cancers to train a diagnostic platform called Elephas. The goal is to see how accurately it can predict whether a patient will respond to immunotherapy or chemoimmunotherapy. About 324 participant…

This study is creating a large registry and biorepository of information and samples from 1,000 people with bladder cancer. Researchers will collect blood, urine, and tissue samples over two years to study how they relate to tumor development, recurrence, and survival. The goal i…

This study looks at how bladder cancer surgery affects quality of life and urinary function. Researchers will compare patients who had partial bladder removal with those who had full bladder removal. The goal is to understand which approach leads to better daily living and urinar…

This study is a large registry that will follow about 8,000 cancer patients who receive radiation therapy using a special machine called an MR-Linac, which combines an MRI scanner with a radiation beam. The goal is to learn how well this technology works for different cancers, in…

This study looks at how bladder sensations during filling are linked to overactive bladder severity in people with multiple sclerosis. Researchers will perform repeated cystometries, including a test with a distracting task, to assess sensation reliability. The goal is to better …

This study explores whether wearable bladder devices can help monitor and treat bladder problems in postpartum women and men after prostate surgery. Researchers will test a wearable ultrasound and an intravaginal exerciser to see if they provide useful data for patients and thera…

This study aims to collect electrical signals from the body in people with overactive bladder, fecal incontinence, or urinary retention who are receiving sacral neuromodulation therapy. Researchers will gather data at several time points during the evaluation period to better und…

This study looks at how urological diseases and their treatments impact patients' work life. Researchers will survey 2,000 adults admitted to a hospital in Poland, focusing on those having major cancer surgeries or stone procedures. Participants will be followed for 6 months to t…

This study looks at nerve damage (peripheral neuropathy) in people with advanced bladder cancer who are getting a combination of two drugs, pembrolizumab and enfortumab vedotin, as their first treatment. About 80 participants will be followed for a year to see how often nerve pro…

This study looks at whether a short survey called the Geriatric-8 can help doctors choose the best treatment for older patients with advanced bladder cancer who cannot take the strong chemotherapy drug cisplatin. Researchers will compare quality of life and side effects between t…

This study compares a new orally disintegrating form of Trimedat (trimebutine) to the standard tablet in 36 healthy adults. The goal is to see if the new version is absorbed similarly and is safe. This trial does not treat any disease; it only gathers data on how the drug behaves…

This study compares two approaches after ureteroscopy for ureteral stones: placing a temporary stent (a small tube) or leaving it out. Researchers want to see if skipping the stent reduces pain and complications. Sixty adults with ureteral stones will be randomly assigned to one …

This study watches how hospitals handle patients admitted with blood in their urine (hematuria). It will track things like how long people stay in the hospital and how quickly they get a diagnosis. The goal is to find the best ways to manage this condition and create guidelines f…

This study tests a new method to help patients understand complex spine or prostate surgeries before they agree to them. Instead of just reading a form, patients watch multimedia content and answer questions to check their understanding. The goal is to see if this approach makes …

This study looks at how well three AI models—ChatGPT, Gemini, and Deepseek—can diagnose and suggest treatments for urology diseases. Researchers will use 800 past patient records from four hospitals to check the AI's accuracy and usefulness. The goal is to understand if AI can he…

This study is testing a new way to choose chemotherapy for muscle-invasive bladder cancer. Doctors will grow a miniature version of a patient's tumor in the lab (called an organoid) and test different drugs on it to see which works best. Then, the patient receives the drug that k…

This study looks at how hyperbaric oxygen therapy (HBOT) affects symptoms and urine markers in people with chronic radiation cystitis, a bladder condition caused by past radiation treatment. Researchers will collect urine, blood, and tissue samples from 100 participants before, d…

This study looks at how adults with bladder problems decide which Coloplast catheter (SpeediCath or Luja) works best for them when they start self-catheterization. Researchers will track satisfaction and challenges over six months. The goal is to help healthcare providers recomme…

This study aims to understand the sexual health challenges faced by bladder cancer patients and develop a support program tailored to their needs. Researchers will interview 30 patients to learn about their experiences and preferences for professional help. The goal is to create …

This study collects tissue and blood samples from 1,500 people with prostate or bladder cancer that has come back or spread. Researchers will analyze the samples to find genetic changes and other markers that may explain why some cancers stop responding to treatment. The goal is …

This study follows 400 patients who have had urologic cancer surgery with lymph node removal to see how often they develop lymphedema (leg swelling). Researchers will use questionnaires and special devices to measure swelling and tissue fluid over two years. The goal is to better…

This study collects blood and leftover tissue samples from 9,600 people with various cancers, including breast, lung, and pancreatic cancer. Researchers will use these samples to improve tests that look for cancer DNA in the blood. The goal is to better detect if cancer returns o…

This study looks at the best times to send messages that encourage physical activity to older cancer survivors (65+) who have chronic pain. About 50 participants will wear an activity tracker and rate their pain four times a day using a smartphone app. The goal is to see if certa…

This early-phase trial is testing two new antibody fragments that are designed to attach to a sugar molecule found on many solid tumors. The fragments are labeled with a radioactive tracer so they can be seen on PET/CT scans. The study aims to see where these fragments go in the …

This study aims to understand how electrical stimulation of the sacral nerve helps people with overactive bladder. Researchers will test two different ways to set the stimulation and see which one works better. Fifteen adults who already qualify for a sacral nerve implant will pa…

This study aims to find genetic factors that may cause interstitial cystitis (also called bladder pain syndrome). Researchers are collecting blood or saliva samples and medical information from 1,000 people with the condition and their family members across North America. No trea…

This early study tests a new approach for stress urinary incontinence (leaking urine when coughing, sneezing, or exercising). Researchers will stimulate nerves near the urethra in 20 women to see if it increases urethral pressure, which could help prevent leaks. The goal is to un…

This study tests a personalized mobile tool to help women with overactive bladder (OAB) start and stick with treatment. About 30 women will use the app to learn about their condition, track symptoms, and get support. The goal is to see if the tool improves bladder health knowledg…

This study tracks 100 cancer survivors aged 18–74 to see how common muscle loss (sarcopenia) and cognitive problems ('chemo brain') are after treatment. Participants undergo physical and mental assessments. The goal is to better understand these long-term side effects and guide p…

This study looks at women aged 50 and older who have visible blood in their urine along with a bladder infection. Researchers want to find out if these women really need to undergo invasive tests like cystoscopy and CT scans to check for bladder or kidney cancer. By following 300…

This study looks at whether using ultrasound imaging and muscle activity sensors together can help women with weak pelvic floor muscles stick with their exercises and get better results. About 70 women will try different feedback methods during training. The goal is to find the b…

This study looks at how the standard BCG treatment for non-muscle invasive bladder cancer may affect patients' mood. Researchers will collect urine and blood samples to measure immune responses, and participants will fill out mood questionnaires and daily diaries. The goal is to …