Could a vaginal probiotic replace antibiotics for recurrent UTIs?
NCT ID NCT07186465
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study compares two ways to prevent repeat urinary tract infections (UTIs) in women after menopause. One group takes a nightly antibiotic pill for 6 months, while the other uses a vaginal tablet containing a probiotic (Lactobacillus) and a tiny amount of estrogen. The goal is to see which approach better prevents infections and how they affect the urinary microbiome. About 100 women will participate for 6 months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Nitrofurantoin (antibiotic) and Gynoflor (vaginal tablet containing Lactobacillus with ultra-low-dose estriol)
- What this could lead to
- If it works, this could point toward a non-antibiotic option to prevent recurrent UTIs in postmenopausal women, reducing antibiotic use and resistance.
- What could go wrong
- This is a small pilot study (100 participants) and may not provide definitive answers. The probiotic approach may be less effective than antibiotics, and individual results may vary.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Faculty of Medicine Ramathibodi Hospital Mahidol University
RECRUITINGBangkok, Phayatai Ratchathewi, 10400, Thailand
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- New symptom diaries aim to improve daily tracking of recurrent UTIs, especially for seniors
- Could fewer antibiotics be better for older women with urinary symptoms?
- Could a probiotic plus smart antibiotic use end the cycle of recurrent UTIs in children?
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- Can antibiotic wash and suction stop Post-Surgery infections?