Could a probiotic plus smart antibiotic use end the cycle of recurrent UTIs in children?
NCT ID NCT06149676
First seen Jul 01, 2026 · Last updated Jul 01, 2026
Summary
This early-phase trial tests whether taking a daily probiotic (Saccharomyces boulardii) and using a targeted antibiotic (ciprofloxacin) only when a UTI occurs can reduce the number of repeat infections in children aged 2 to 17. Participants have had at least three UTIs in the past year or two in the last six months. The study compares this approach to standard care to see if it lowers future UTI episodes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Saccharomyces boulardii (probiotic) and ciprofloxacin (antibiotic)
What this could lead to
If it works, this could offer a new way to prevent frequent UTIs in children without long-term daily antibiotics.
What could go wrong
This is a very early, small trial (35 participants) so results may not apply broadly. The approach depends on the infection being sensitive to ciprofloxacin, which may not always be the case.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Lurie Children's Hospital
Chicago, Illinois, 60611, United States