Could a probiotic plus smart antibiotic use end the cycle of recurrent UTIs in children?
NCT ID NCT06149676
First seen Jul 01, 2026 · Last updated Jul 02, 2026 · Updated 1 time
Summary
This early-phase trial tests whether taking a daily probiotic (Saccharomyces boulardii) and using a targeted antibiotic (ciprofloxacin) only when a UTI occurs can reduce the number of repeat infections in children aged 2 to 17. Participants have had at least three UTIs in the past year or two in the last six months. The study compares this approach to standard care to see if it lowers future UTI episodes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Saccharomyces boulardii (probiotic) and ciprofloxacin (antibiotic)
- What this could lead to
- If it works, this could offer a new way to prevent frequent UTIs in children without long-term daily antibiotics.
- What could go wrong
- This is a very early, small trial (35 participants) so results may not apply broadly. The approach depends on the infection being sensitive to ciprofloxacin, which may not always be the case.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Lurie Children's Hospital
Chicago, Illinois, 60611, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- New symptom diaries aim to improve daily tracking of recurrent UTIs, especially for seniors
- Could fewer antibiotics be better for older women with urinary symptoms?
- Scientists create first tools to measure recurrent UTI burden
- Simple sugar may shield catheter users from painful infections
- Can good bacteria beat bladder infections? new study investigates
- Hiprex trial for recurrent UTIs halted early – little data to go on