New combo therapy aims to fight bladder cancer without surgery

NCT ID NCT04106115

Recruiting now Disease control Sponsor: University College, London Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study investigates whether combining the immunotherapy drug durvalumab with a cancer vaccine (S-488210/S-488211) can help people with a type of bladder cancer that has not responded to standard treatment. The trial includes adults with high-risk non-muscle invasive bladder cancer who cannot or choose not to have their bladder removed. Participants receive the drug intravenously and the vaccine as injections under the skin, and researchers monitor for side effects and how long the cancer stays away.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: durvalumab and S-488210/S-488211 vaccine
What this could lead to: If successful, this combination could offer a new treatment option for people with high-risk bladder cancer who have not responded to standard therapy, potentially avoiding the need for bladder removal.
What could go wrong: This is an early-phase trial with a small number of participants, so the results may not apply to everyone. The combination may cause side effects, and it is not yet known if it will be more effective than existing treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for BLADDER CANCER are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

non-invasive bladder urothelial carcinoma Non-Muscle Invasive Bladder Neoplasms urinary bladder carcinoma Urinary Bladder Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BLADDER CANCER

Contacts and locations

Locations

Cambridge University NHS FT
RECRUITING

Cambridge, United Kingdom
Guy's and St Thomas' NHS Foundation Trust
RECRUITING

London, United Kingdom
Royal Free London NHS FT
RECRUITING

London, United Kingdom
The Christie NHS Foundation Trust
RECRUITING

Manchester, United Kingdom
The Royal Marsden NHS Foundation Trust
RECRUITING

London, United Kingdom
University College London Hospital NHS Foundation Trust
RECRUITING

London, United Kingdom
University Hospital Southampton NHS Foundation Trust
RECRUITING

Southampton, United Kingdom

More trials for these conditions

Other studies related to the condition(s) this trial covers.