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New drug combo aims to shrink bladder tumors before surgery

NCT ID NCT06511648

Recruiting now Disease control Sponsor: Spanish Oncology Genito-Urinary Group Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 trial tests erdafitinib alone or with cetrelimab before surgery in 90 people with muscle-invasive bladder cancer that has specific gene changes (FGFR). Participants cannot take standard cisplatin chemotherapy. The goal is to see if the drugs can eliminate or shrink the tumor before removal, improving outcomes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

erdafitinib and cetrelimab

What this could lead to

If successful, this could offer a new treatment option before surgery for people with a specific type of bladder cancer who cannot take standard chemotherapy.

What could go wrong

This is an early phase 2 trial with only 90 participants, so results are not yet proven. The drugs may cause side effects or not work as hoped.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

infiltrating bladder urothelial carcinoma transitional cell carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MUSCLE-INVASIVE BLADDER CANCER

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • A.O. Ordine Mauriziano, Ospedale Umberto I

    WITHDRAWN

    Turi, 10128, Italy

  • Barts Health NHS Trust

    RECRUITING

    London, W6 8JA, United Kingdom

    Contact Email: •••••@•••••

  • CLCC Jean Perrin

    RECRUITING

    Clermont-Ferrand, 63011, France

    Contact Email: •••••@•••••

  • CLCC Léon Bérard

    WITHDRAWN

    Lyon, 69008, France

  • Charing Cross Hospital

    RECRUITING

    London, United Kingdom

    Contact Email: •••••@•••••

  • Complexo Hospitalario Universitario A Coruña

    RECRUITING

    A Coruña, Galicia, 15006, Spain

    Contact Email: •••••@•••••

    Contact

  • Fundación Instituto Valenciano De Oncología

    RECRUITING

    Valencia, 46009, Spain

    Contact Email: •••••@•••••

  • Hospital Clínic De Barcelona

    RECRUITING

    Barcelona, Catalonia, 08036, Spain

    Contact

    Contact

  • Hospital Clínico Universitario De Valladolid

    RECRUITING

    Valladolid, 47003, Spain

    Contact Email: •••••@•••••

  • Hospital De Sabadell (Parc Taulí)

    RECRUITING

    Barcelona, Catalonia, 08208, Spain

    Contact Email: •••••@•••••

  • Hospital Universitario 12 de Octubre

    RECRUITING

    Madrid, 28041, Spain

    Contact Email: •••••@•••••

  • Hospital Universitario Lucus Augusti

    RECRUITING

    Lugo, Galicia, 27003, Spain

    Contact Email: •••••@•••••

    Contact

  • Hospital Universitario Miguel Servet

    RECRUITING

    Zaragoza, 50009, Spain

    Contact Email: •••••@•••••

  • Hospital Universitario de Toledo

    RECRUITING

    Toledo, 45007, Spain

    Contact Email: •••••@•••••

  • ICO l' Hospitalet

    NOT_YET_RECRUITING

    Barcelona, 08908, Spain

    Contact Email: •••••@•••••

  • IRCCS San Raffaele Hospital and Scientific Institute

    RECRUITING

    Milan, 20132, Italy

    Contact Email: •••••@•••••

  • IUCT

    RECRUITING

    Toulouse, 31059, France

    Contact Email: •••••@•••••

  • Institut Gustave Roussy

    RECRUITING

    Villejuif, 94805, France

    Contact Email: •••••@•••••

  • Institut Mutualiste Montsouris

    RECRUITING

    Paris, 75014, France

    Contact Email: •••••@•••••

  • Ospedale Molinette

    RECRUITING

    Turin, 10126, Italy

    Contact Email: •••••@•••••

  • Sheffield Teaching Hospitals NHS Foundation Trust

    RECRUITING

    Sheffield, S10 2SJ, United Kingdom

    Contact Email: •••••@•••••

  • The Royal Marsden NHS Foundation Trust

    RECRUITING

    London, SW3 6JJ, United Kingdom

    Contact Email: •••••@•••••

  • University Hospitals of Morecambe Bay NHS Foundation Trust

    WITHDRAWN

    Lancaster, LA1 4RP, United Kingdom