New MRI-Guided radiation trial aims to sharpen cancer treatment

NCT ID NCT04368702

Recruiting now Disease control Sponsor: Brigham and Women's Hospital Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a new type of radiation machine that uses MRI to guide treatment is safe and practical for people with gastric, breast, or other cancers. About 70 adults will receive radiation guided by real-time MRI, sometimes with chemotherapy. The goal is to see if this approach can better target tumors and track changes during treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: MR-image guided radiation therapy (MRIdian Linear Accelerator)
What this could lead to: If successful, this could show that MRI-guided radiation is safe and feasible for several cancers, potentially improving tumor control and reducing side effects.
What could go wrong: This is an early feasibility study with only 70 participants across multiple cancer types. Results may not apply to all patients, and side effects from radiation plus chemotherapy are possible.

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Conditions

The condition(s) this trial relates to.

breast cancer breast carcinoma in situ gastric cancer gastric neoplasm invasive breast carcinoma laryngeal disorder laryngeal neoplasm larynx cancer lymphoma mantle cell lymphoma urinary bladder carcinoma Urinary Bladder Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BLADDER CANCER GASTRIC CANCER IN SITU BREAST CANCER INVASIVE BREAST CANCER LARYNX CANCER MANTLE CELL LYMPHOMA

Contacts and locations

Locations

Brigham & Women's Hospital
RECRUITING

Boston, Massachusetts, 02115, United States
Dana Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02115, United States

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