INVASIVE BREAST CANCER

This study compares a one-week ultra-hypofractionated radiation regimen (26 Gy in 5 fractions) to the standard three-week moderate hypofractionated regimen (40 Gy in 15 fractions) for treating lymph nodes after breast cancer surgery. The goal is to see if the shorter course is ju…

This study is for people with breast cancer who need a mastectomy (breast removal) followed by immediate breast reconstruction using their own tissue. It compares two ways of giving radiation before surgery: the standard longer course versus a shorter course with fewer, higher do…

This study tests a new drug called ASP546C in people with advanced stomach, gastroesophageal junction, pancreatic, or certain other solid tumors. The drug is given as an infusion every 3 weeks. The study has two parts: Part 1 finds the best dose in stomach/GEJ cancer patients, an…

This phase 2 study is testing a drug called sacituzumab govitecan, alone or with pembrolizumab, given before surgery to people with localized triple-negative breast cancer. The goal is to see if these drugs can eliminate all cancer cells in the breast and lymph nodes before surge…

This study is testing whether shorter courses of radiation therapy can work as well as standard treatment for people with breast cancer that has spread to lymph nodes. About 768 participants who have had surgery will receive either a very short (ultrahypofractionated) or moderate…

This study looks at whether taking vitamin D supplements during standard chemotherapy can help more tumors disappear in people with triple-negative breast cancer who are low in vitamin D. About 50 participants will receive vitamin D plus chemotherapy, and researchers will compare…

This study tests whether freezing early-stage breast cancer tumors (cryoablation) can safely and effectively destroy them in postmenopausal women. Participants will have the frozen tumor removed afterward to check for any remaining cancer cells. The goal is to see if this less in…

This study compares two surgical approaches for breast cancer: one that removes extra tissue around the tumor (routine cavity shave margins) and one that uses a special device (Savi Scout®) to guide removal of only suspicious margins. About 204 women with early-stage breast cance…

This early study tests a device called Muse MRgFUS that uses focused ultrasound waves to heat and destroy a portion of a breast tumor without any cuts. Thirty-four women with breast cancer will have part of their tumor ablated before their standard surgery. The goal is to see if …

This study is testing whether personalizing the dose and schedule of radiation therapy after breast cancer surgery can reduce long-term side effects like scarring (fibrosis) and radiation-induced cancers, while still preventing the cancer from coming back. The trial will enroll 8…

This phase 3 trial is testing whether giving radiation only to the lower armpit lymph nodes works as well as giving radiation to a larger area of lymph nodes in breast cancer patients who have 1-2 positive sentinel nodes. The study plans to enroll 1608 women with early-stage brea…

This study is for people with advanced breast cancer (T3 or T4) who have responded well to chemotherapy. Usually, radiation is given after mastectomy, which delays reconstruction. Here, radiation is given before surgery, so reconstruction can happen immediately using the patient'…

This study tests whether a new type of radiation machine that uses MRI to guide treatment is safe and practical for people with gastric, breast, or other cancers. About 70 adults will receive radiation guided by real-time MRI, sometimes with chemotherapy. The goal is to see if th…

This study tests a new 3D-printed biodegradable mesh used with a silicone implant for immediate breast reconstruction after mastectomy in women with breast cancer. The goal is to see if the mesh improves cosmetic results, patient satisfaction, and safety. The trial will enroll 25…

This phase II trial is testing whether a targeted drug called trastuzumab deruxtecan (Enhertu), given alone or with anastrozole (Arimidex), can eliminate HER2-low, hormone receptor positive breast cancer before surgery. The study will enroll 88 people with early-stage breast canc…

This study tests whether a daily pill (Z-endoxifen) plus a monthly shot (goserelin) can slow or stop estrogen-driven breast cancer growth in premenopausal women. About 87 participants will take the drugs for up to 24 weeks before surgery. The main goal is to see if the treatment …

This registry study is following 500 women with early-stage breast cancer who receive a single dose of radiation directly to the tumor site during surgery (IORT). The goal is to see how well this approach controls cancer locally and what side effects occur. Participants are women…

This study is testing whether a genetic test called RecurIndex can identify breast cancer patients with cancer in their lymph nodes who can safely skip radiation to the lymph nodes. The goal is to reduce side effects like arm swelling and pain without increasing the risk of cance…

This phase II trial is testing whether combining two drugs—trastuzumab deruxtecan (Enhertu) and durvalumab—given before surgery can eliminate cancer in people with stage III inflammatory breast cancer that has HER2 protein. The study will enroll 63 participants and measure how ma…

This study tests whether giving a single dose of radiation during breast-conserving surgery works as well as standard weeks-long radiation for early-stage, HER2-negative breast cancer. About 620 women aged 55 and older will take part. The goal is to see if this approach lowers th…

This study is testing whether a special whole-body MRI scan can find breast cancer that has come back or spread to other parts of the body earlier than standard methods. Researchers will follow 145 women with aggressive breast cancer types (HER2+ or triple-negative) for five year…

This study tests whether a green dye called indocyanine green (ICG) can accurately find cancer that has spread to lymph nodes in breast cancer patients who have already had chemotherapy. About 100 adults will receive the dye along with standard methods during surgery. The goal is…

This phase 2 trial tests whether drinking tart cherry juice can prevent nerve damage (neuropathy) caused by the chemotherapy drug paclitaxel in breast and ovarian cancer patients. About 86 participants will be randomly assigned to receive either a high or low dose of the juice du…

This study compares a newer, less invasive mastectomy technique (endoscopic skin-sparing) with the standard approach in 258 women with breast cancer. The goal is to see if the endoscopic method leads to fewer wound complications and higher patient satisfaction. Participants are r…

This early-stage trial is testing whether cannabidiol (CBD), a compound from cannabis, can affect breast cancer cell growth. Up to 84 women with invasive breast cancer will take either a low or high dose of CBD or a placebo for 5 to 56 days before their surgery. Researchers will …

This study tests whether a questionnaire can help doctors spot side effects early in people who have finished treatment for breast or prostate cancer. About 200 survivors will either use the questionnaire or receive standard care. The goal is to see if active monitoring improves …

This study tests whether a decision aid and training for surgeons can help women aged 70 and older with low-risk stage I breast cancer make better treatment choices. About 402 participants will be split into two groups: one where surgeons get shared decision-making training and p…

This study reviews data from 250 women who had a special type of breast-conserving surgery for early-stage breast cancer. The surgery uses nearby skin and fat flaps to fill the area where the tumor was removed, aiming to avoid visible scars and keep the breast looking natural. Re…

This pilot study looks at how social determinants of health—like housing, food, and transportation—relate to inflammation in women newly diagnosed with breast cancer. Participants fill out surveys and give a blood sample at a single visit. The goal is to understand these connecti…

This study is developing and testing artificial intelligence (AI) tools to help doctors make personalized decisions for patients with heart disease, breast cancer, or sepsis. The AI will be designed to explain its recommendations clearly and ensure safety. Researchers will use da…

This study is testing a device called GILUPI CellCollector® that captures circulating tumor cells (CTCs) from a vein in breast cancer patients who have already completed surgery and chemotherapy. The goal is to see if the presence of these cells can help predict whether the cance…

This study tests a new way to mark the area where a breast tumor was removed, so radiation therapy can be more accurately aimed afterward. About 50 adults with early-stage breast cancer or a precancerous condition called DCIS will take part. The goal is to see if this marking hel…

This study collects tissue, blood, and optional rectal swabs from 200 adults with breast cancer or carcinoma in situ. Samples are taken during standard procedures like surgery. Researchers will analyze them to identify tumor biomarkers and genetic profiles, aiming to better under…

This study takes small tumor samples from 240 women with invasive breast cancer who are scheduled for chemotherapy before surgery. Researchers will grow these samples into mini-tumors (organoids) in the lab to study each cancer's unique features. The goal is to see if these lab m…

This study enrolls 3,300 women with invasive breast cancer living in 59 North Carolina counties. It aims to understand how tumor biology, healthcare access, and patient behavior together affect outcomes. All participants receive a structured program to improve communication with …

This study is looking at whether tracking tiny bits of tumor DNA in the blood can help predict if breast cancer will come back after chemotherapy and surgery. Researchers will take blood samples from 180 people every 6 months for 5 years. The goal is to see if these DNA clues can…

This study follows 310 women who had surgery for breast cancer to see how access to supportive care (like counseling or nutrition advice) affects their quality of life. Participants fill out several questionnaires about their physical, emotional, and social well-being over time. …