INVASIVE BREAST CANCER

This study is testing whether a combination of two drugs, trastuzumab deruxtecan and durvalumab, can shrink tumors before surgery in people with stage III inflammatory breast cancer that expresses the HER2 protein. The goal is to see if this treatment can eliminate all detectable…

This study is testing whether giving radiation therapy before mastectomy surgery allows for immediate breast reconstruction using the patient's own tissue. Currently, patients with advanced breast cancer typically wait months after surgery for reconstruction. Researchers want to …

This study is testing whether using MRI scans during radiation treatment can help doctors target cancer more precisely while patients receive chemotherapy. Researchers want to see if this approach is safe and practical for treating gastric and breast cancers. The study involves 7…

This study is testing a new drug combination for premenopausal women with a common type of breast cancer (ER+/HER2-) before they have surgery. The goal is to see if taking the drug (Z)-endoxifen with a monthly injection (goserelin) can slow or stop tumor growth, potentially shrin…

This study is testing whether giving vitamin D supplements to patients with triple-negative breast cancer who are also vitamin D deficient can help their chemotherapy work better. Researchers want to see if the supplements help more patients achieve a 'pathologic complete respons…

This study is testing a newer targeted drug called trastuzumab deruxtecan, given alone or with a hormone-blocking pill (anastrozole), before surgery for early-stage breast cancer. The goal is to see which approach is better at shrinking or eliminating the tumor. It is for people …

This study is testing whether the drug sacituzumab govitecan, alone or combined with pembrolizumab, can shrink tumors before surgery in people with localized triple-negative breast cancer. About 260 participants will receive the study treatment for up to 12 weeks, followed by sta…

This study is testing whether a special full-body MRI scan can find breast cancer that has returned or spread to other parts of the body earlier than current methods. It will enroll 145 women with high-risk forms of breast cancer (HER2-positive or Triple Negative) who have finish…

This study is testing whether drinking tart cherry juice can prevent nerve pain (neuropathy) caused by a common chemotherapy drug called paclitaxel. It will enroll 86 people with breast or ovarian cancer who are starting this type of chemo. Participants will be randomly assigned …

This study aims to collect breast cancer tissue and blood samples from patients to build a research repository. The goal is to analyze these samples to better understand the disease, identify biomarkers, and study its genetic makeup. Participants will provide samples during their…

This study aims to collect tumor samples from 240 breast cancer patients before they start chemotherapy. Researchers will use these samples to grow miniature 3D tumor models called organoids in the lab. By studying these organoids and tiny particles they release, the study hopes …