INVASIVE BREAST CANCER

This early-phase study is testing a personalized vaccine for people with HER2-positive breast cancer. The vaccine is made from the patient's own immune cells and is designed to teach the body's immune system to attack the cancer. Researchers are giving the vaccine alongside stand…

This study is testing whether adding an immunotherapy drug (pembrolizumab) to a targeted cancer drug (sacituzumab govitecan) works better than the targeted drug alone for people with a specific type of advanced breast cancer that has stopped responding to hormone therapy. About 1…

This study is testing whether adding a new, experimental drug called onvansertib to a standard chemotherapy (paclitaxel) is safe and effective for people with triple-negative breast cancer that has spread. The first part finds the safest dose, and the second part checks if the co…

This study is testing if adding an immunotherapy drug called cemiplimab to standard chemotherapy before surgery works better for certain high-risk breast cancers. It will involve 36 women with locally advanced breast cancer that tests positive for specific markers. The main goal …

This study is testing whether a pill called olaparib can help control metastatic breast cancer that has spread in the body. It is for patients whose cancer has a specific weakness—a mutation in certain genes that help repair damaged DNA. The goal is to see if targeting this weakn…

This study aims to see if doctors can reliably measure the amount of a common chemotherapy drug (paclitaxel) in a patient's blood. The goal is to learn if tracking these levels can help find the right dose to fight cancer while reducing a severe side effect: nerve damage that cau…

This study aims to grow 3D models called 'organoids' from the tumors of 50 breast cancer patients. Researchers will use these mini-tumors to collect tiny particles that cells naturally release, which can seek out cancer tissue. The goal is to learn if these particles can be used …