Could a common blood pressure drug prevent radiation scarring in breast cancer patients?

NCT ID NCT05637216

Ongoing Disease control Sponsor: Shaw Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether losartan, a drug already used for high blood pressure, can reduce scarring (fibrosis) caused by radiation therapy in breast cancer patients. 43 women who had breast surgery and need radiation will receive either losartan or a placebo. Researchers will measure breast and lung scarring using exams and CT scans, along with blood markers of inflammation and aging cells.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Losartan (a blood pressure drug)
What this could lead to: If it works, this could point toward a way to prevent or reduce scarring and stiffness in breast tissue and lungs after radiation therapy.
What could go wrong: This is a small, early-phase pilot study with only 43 participants. The drug is already approved for blood pressure, but its effect on radiation fibrosis is unproven, and results may not apply to all patients.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm Camurati-Engelmann Syndrome ductal breast carcinoma in situ Fibrosis Inflammation invasive breast carcinoma Radiation Fibrosis Syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RADIATION INDUCED FIBROSIS

Contacts and locations

Locations

Vail Health Shaw Cancer Center

Edwards, Colorado, 81632, United States

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