Radiation-Free option for Low-Risk breast cancer?

NCT ID NCT02400190

Ongoing Knowledge-focused Sponsor: University of Michigan Rogel Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study follows 202 postmenopausal women with early-stage, hormone-sensitive breast cancer who choose to skip radiation after lumpectomy and take only hormone therapy. Researchers track cancer recurrence over 10 years to see if this approach is safe for this low-risk group. The goal is to gather evidence that might spare future patients from unnecessary radiation.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: endocrine therapy alone without radiotherapy
What this could lead to: If successful, this could show that carefully selected patients can avoid radiation and its side effects without increasing cancer recurrence risk.
What could go wrong: This is an observational study, not a treatment trial. It only tracks outcomes in a very specific, low-risk group, so results may not apply to most breast cancer patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast neoplasm invasive breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST NEOPLASMS

Contacts and locations

Locations

East Carolina University

Greenville, North Carolina, 27853, United States
Harvard University

Cambridge, Massachusetts, 02138, United States
Johns Hopkins University

Baltimore, Maryland, United States
Loyola University Medical Center

Maywood, Illinois, 60153, United States
Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Northwell Health

Lake Success, New York, 11042, United States
Rutgers Cancer Institute of New Jersey

New Brunswick, New Jersey, 08901, United States
Stanford University

Stanford, California, 94305, United States
University of Michigan

Ann Arbor, Michigan, 48109, United States
University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States
University of Texas Southwestern Medical Center

Dallas, Texas, 75390, United States
Yale University

New Haven, Connecticut, 06520, United States

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