University Of Michigan Rogel Cancer Center

This early-stage trial tests a new treatment for children and young adults (ages 3-39) with recurrent malignant brain tumors that can be surgically removed. The therapy uses two modified viruses injected into the tumor to kill cancer cells and train the immune system to attack th…

This study tests whether combining two drugs, pembrolizumab and mogamulizumab, can shrink or eliminate advanced cutaneous T-cell lymphoma that has come back or not responded to prior treatment. About 23 adults with stage IIB-IVB disease will receive the drugs in 6-week cycles for…

This study tests whether the immunotherapy drug pembrolizumab can shrink or control advanced or recurrent skin cancer near the eye. About 22 adults with this condition will receive the drug and be monitored for tumor response and whether the eye can be saved. The goal is to see i…

This study tests a drug called ivonescimab given before surgery for people with stage II to IV head and neck cancer that can be removed. The drug helps the immune system attack cancer cells. About 28 adults will take part to see if the drug shrinks tumors and is safe.

This study tests the drug pacritinib in people with T-cell lymphoma that has returned or not responded to prior treatments. The goal is to see how well the drug shrinks or controls the cancer. About 100 adults will take part, and their response will be measured using scans and sk…

This study tests an experimental drug called ESK981 in people with advanced pancreatic cancer, certain neuroendocrine tumors, or neuroendocrine prostate cancer. Participants take ESK981 capsules in a 5-days-on, 2-days-off cycle. The main goal is to see if the drug can keep the ca…

This study tests whether adding a special potato starch and an iron-lowering drug to standard care can help people who receive a stem cell transplant for blood diseases. About 50 adults will take the combination to see if it reduces serious side effects like graft-versus-host dis…

This study tests whether taking prednisone before and during radiation therapy can reduce liver inflammation in people with liver cancer. About 20 participants will take prednisone for a short time around their radiation sessions. The goal is to see if this approach lowers the ri…

This study compares two drugs, leuprolide and goserelin, to see how well they lower estrogen in premenopausal women with breast cancer. Both drugs stop the ovaries from making estrogen, which can fuel cancer growth. The trial will test if leuprolide works as well as goserelin. Ab…

This early-phase study tests gilteritinib, a drug already approved for leukemia, in 30 people with stage IV ALK-positive non-small cell lung cancer whose tumors stopped responding to standard treatments. The main goals are to find the safest dose and check for side effects. Resea…

This study tests a combination of two drugs, ruxolitinib and enzalutamide, in men with advanced prostate cancer that has spread and no longer responds to hormone therapy. The goal is to find the safest dose and see if the combo can shrink tumors or lower PSA levels. About 20 part…

This study tests whether giving a personalized, less intense treatment plan to people with early-stage HPV-related throat cancer can keep the cancer from coming back while reducing side effects. About 150 participants will either have surgery followed by observation or limited ra…

This study looks at whether simply monitoring low-risk basal cell skin cancer (a slow-growing, rarely spreading cancer) is a safe and comfortable choice for people aged 65 and older, instead of standard treatments like scraping or surgery. Standard treatments can cause bleeding o…

This study looks for proteins in stool or blood that might signal colon cancer or pre-cancerous polyps. Researchers hope to create a simpler, more affordable screening option. About 1,200 adults will provide samples and compare results with colonoscopy findings.

This early-phase study is testing a new imaging agent called [68Ga]Ga-FAPI-04 to see where it collects in the bodies of 30 people with high-grade neuroendocrine tumors. The goal is to learn if this tracer can help detect these cancers better on PET/CT scans. Participants will rec…

This study looks at whether different amounts of exercise can help prevent colorectal polyps from coming back in people with Familial Adenomatous Polyposis (FAP). About 32 participants will follow a personalized treadmill program at home for 26 weeks. Researchers will take small …

This study tests whether personalized diet advice from a registered dietitian can reduce fatigue and improve sleep and quality of life in lymphoma survivors. About 100 adults with persistent tiredness will receive 8 counseling sessions over 3 months by phone or video. The goal is…

This study is testing whether an 8-week exercise program, called prehabilitation, can improve heart fitness and reduce heart complications in people at high risk who are about to have a stem cell transplant. About 10 adults with at least one heart risk factor will take part. The …

This pilot study is testing a 12-week exercise program designed for Black women who have finished treatment for early-stage breast cancer. The goal is to see if the program is practical and enjoyable, and whether it helps improve physical and emotional well-being. About 75 women …

This study compares two radiation schedules for men whose prostate cancer has returned after surgery. One schedule uses fewer, higher-dose sessions (ultra-hypofractionated), while the other uses a standard moderate approach. The goal is to see which one leads to better quality of…

This study tests a simple decision aid for breast cancer patients experiencing nerve damage (numbness or tingling) from chemotherapy. The tool provides information about long-term nerve symptoms, helps clarify treatment priorities, and prepares patients to discuss options with th…

This study tests a short, virtual therapy called solution-focused brief therapy (SFBT-C) to see if it reduces anxiety and depression in teens and young adults who have had cancer. About 60 participants aged 15-39 who are distressed will either get SFBT-C or standard care. The goa…

This study tests whether a virtual diet program (low added sugar, high fiber, and omega-3s) can help cancer survivors manage nerve pain, numbness, and tingling caused by chemotherapy. About 50 adults who finished chemo at least three months ago and still have moderate nerve sympt…

This study tests whether a dietary supplement called resistant potato starch can help prevent joint pain and stiffness caused by aromatase inhibitors, a common breast cancer treatment. About 20 people with early-stage breast cancer or at high risk for it will take the starch whil…

This study is for women with a high-risk type of breast cancer (HR+/HER2-). It tests whether adding the drug ribociclib to standard radiation therapy after surgery is safe and tolerable. About 30 participants will take ribociclib daily for up to 6 weeks while receiving radiation.…

This study looks at whether giving a longer infusion of the chemotherapy drug paclitaxel to cancer patients with low muscle mass can make drug levels in their blood more like those in patients with normal muscle mass. About 22 women with breast, stomach, or esophageal cancer will…

This study tests a special needle that uses light and sound to check prostate tissue during a standard biopsy. The goal is to see if it can reliably tell the difference between healthy and cancerous areas without taking extra samples. About 50 men scheduled for a prostate biopsy …

This study looks at 200 people with metastatic leiomyosarcoma who are starting chemotherapy. Researchers collect blood samples before and during treatment to measure circulating tumor DNA (ctDNA) and see if changes in ctDNA can predict tumor shrinkage or longer survival. The goal…

This study looks at whether a special lung scan (called PRM) can help detect chronic lung injury in people who have had a blood stem cell transplant. Researchers will follow 375 patients for one year to see if the scan can predict who will develop lung problems or get worse. The …

This study looks at whether a blood test (ctDNA) and special scans can help predict how well chemotherapy works in people with a rare cancer called leiomyosarcoma. About 40 participants will give blood samples and have scans before, during, and after treatment. The goal is to fin…

This study tests an online platform for people with lung, colorectal, breast, or prostate cancer to track medication side effects and concerns at home. About 80 participants will use the tool and report on its ease of use and how it affects their health. The goal is to see if sel…

This study tests whether web-based tools can help people with hereditary cancer syndromes share risk information with their relatives and encourage them to get genetic testing. About 500 participants (patients and their family members) will use an online platform to invite relati…

This study is testing whether a new type of CT scan can provide clearer pictures of tumors during radiation therapy. Researchers will enroll 30 adults with pelvic or genitourinary cancers who are receiving standard radiation treatment. The goal is to compare image quality between…