University Of Michigan Rogel Cancer Center

This study is testing an experimental oral medication called ESK981 for people with advanced pancreatic cancer and certain neuroendocrine cancers that have stopped responding to standard treatments. The trial will enroll 66 patients across three groups to see if taking ESK981 on …

This study compares two different hormone-blocking treatments (leuprolide and goserelin) for premenopausal women with breast cancer. Both drugs work by reducing estrogen production, which can help slow or stop cancer growth. Researchers will measure how well each treatment lowers…

This early-stage study is testing a new combination therapy for children and young adults whose primary brain tumors have returned. The treatment involves injecting two modified viruses directly into the tumor during surgery to kill cancer cells and alert the immune system, follo…

This study is testing if the immunotherapy drug pembrolizumab can help treat a specific type of skin cancer that is advanced or has come back around the eye. The goal is to see if the drug can shrink these difficult-to-treat tumors and help patients keep their eye. About 22 adult…

This study is testing two personalized approaches to treat early-stage throat cancer caused by HPV. The goal is to control the cancer effectively while using less intense treatments to reduce side effects. One approach starts with surgery, and the other uses tailored radiation an…

This early-stage study is testing whether adding the drug ruxolitinib to the standard treatment enzalutamide is safe and effective for men with advanced prostate cancer that has stopped responding to hormone-blocking therapy. The goal is to find the best dose and see if this comb…

This study is testing if a new drug called ivonescimab can help shrink tumors before surgery for head and neck cancer. The drug is designed to help the body's immune system fight the cancer cells. Researchers will give the drug to about 28 patients and then measure how much the t…

This study is testing if a common steroid called prednisone can protect the liver from damage during radiation treatment for liver cancer. Twenty patients at high risk for liver inflammation will take prednisone for a few days before and during their radiation therapy. Researcher…

This study compares two radiation therapy schedules for men who have had prostate cancer surgery. It tests whether a shorter 2-week treatment (5 sessions) affects quality of life differently than the standard 4-8 week treatment. The main goal is to see if the shorter schedule mai…

This study is testing if giving a standard cancer drug (paclitaxel) over a longer time to patients with low muscle mass results in drug levels similar to those seen in patients with normal muscle mass. The goal is to see if this personalized timing approach could make the treatme…

This study is testing whether combining two existing cancer drugs (pembrolizumab and mogamulizumab) can help control advanced cutaneous T-cell lymphoma that has returned or stopped responding to previous treatments. The trial will enroll about 23 adults with this rare type of ski…

This early-stage study is testing a drug called gilteritinib in patients with advanced, ALK-positive non-small cell lung cancer that has stopped responding to other targeted treatments. The main goals are to find the safest dose and understand the side effects. Researchers are st…

This study is testing whether adding a drug called ribociclib to standard radiation therapy is safe for women with high-risk, hormone-positive breast cancer. The goal is to see if this combination can better control the cancer and prevent it from coming back after surgery. Resear…

This study is testing whether taking a resistant potato starch supplement along with the drug deferasirox can help reduce serious complications after a stem cell transplant. The researchers think this combination might protect the gut and lower the risk of graft-versus-host disea…

This study is testing an oral drug called pacritinib for people with specific types of T-cell lymphomas that have come back or stopped responding to other treatments. The main goal is to see how well the drug shrinks the cancer and controls the disease. About 100 participants wil…

This study is testing whether adding a gel made from inulin, a common dietary fiber, makes standard immunotherapy drugs more effective for people with advanced kidney cancer. Researchers think improving gut bacteria health might help the immune system fight cancer better. The tri…

This study is testing a special needle that uses light and sound waves to examine prostate tissue during a standard biopsy procedure. The goal is to see if this tool can reliably detect differences between healthy tissue and cancer without having to remove tissue samples first. T…

This early-stage study is testing whether personalized exercise programs using home treadmills can help prevent colorectal polyps from returning in people with Familial Adenomatous Polyposis (FAP). Researchers will place treadmills in participants' homes and monitor their exercis…

This study is testing whether a short virtual therapy program can better reduce depression and anxiety in young cancer survivors compared to usual care. The therapy focuses on building hope and strengths rather than just discussing problems. Researchers will enroll 60 survivors a…

This study is testing if a virtual diet coaching program can help reduce nerve pain and numbness caused by chemotherapy. Researchers want to see if a diet low in sugar and high in fiber and healthy fats is practical and acceptable for cancer survivors. The main goal is to check i…

This study is testing whether personalized diet counseling from a nutritionist can help lymphoma survivors who have persistent fatigue. Over 100 participants will receive either the special diet plan or general health advice over three months. Researchers will check if the diet i…

This study is testing a 12-week exercise program designed to help Black women who have finished their main breast cancer treatment. Researchers want to see if the program is practical and enjoyable for participants, and if it helps improve their outlook and quality of life. The s…

This study is testing whether adding a genetic test score to standard risk information helps men with newly diagnosed, favorable-risk prostate cancer make better treatment decisions. 900 men will be randomly assigned to either receive their standard risk score alone or their stan…

This study is testing whether a new type of CT scan can provide clearer pictures of tumors during radiation therapy. Researchers will enroll 30 adults with pelvic or genitourinary cancers who are receiving standard radiation treatment. The goal is to compare image quality between…

This study aims to find blood markers that can predict how well chemotherapy works for people with advanced leiomyosarcoma, a rare and aggressive cancer. Researchers will collect blood samples from 200 patients before and during their first chemotherapy treatment to look for canc…

This study is testing whether special web-based tools can help families communicate better about inherited cancer risks. It aims to make it easier for relatives of someone with a hereditary cancer syndrome to learn about and get genetic testing themselves. Researchers want to see…

This study is testing a special type of CT scan, called Parametric Response Mapping (PRM), to see if it can predict which patients will develop serious lung disease after a stem cell transplant. It will follow 375 children and adults who have either just been diagnosed with a tra…

This study aims to find better ways to predict if chemotherapy is working for patients with a type of cancer called leiomyosarcoma. Researchers will test blood samples for tiny pieces of cancer DNA and analyze detailed scans to see if these can tell doctors early on which patient…

This early study is testing a new imaging tracer called [68Ga]Ga-FAPI-04 to see where and how much of it collects in the bodies of patients with high-grade neuroendocrine tumors. Researchers will use PET and CT scans to compare the tracer's uptake in tumors versus normal tissues …

This study is testing whether an online self-monitoring platform is a useful tool for cancer patients. It aims to help patients track side effects and concerns about their oral cancer medications while they are at home. The research will see if using the app improves how patients…