University Of Michigan Rogel Cancer Center

This early-stage trial tests gilteritinib, a drug already approved for leukemia, in 30 people with stage IV ALK-positive non-small cell lung cancer that has stopped responding to other treatments. The main goal is to find the safest dose and check for side effects. Researchers ho…

This phase II trial is testing whether the drug ivonescimab, given before surgery, can shrink tumors in people with stage II-IV head and neck cancer that can be removed. Ivonescimab is a type of antibody that helps the immune system fight cancer. The study will enroll 28 adults w…

This study compares two drugs, leuprolide and goserelin, to see how well they lower estrogen levels in premenopausal women with breast cancer. Both drugs work by temporarily stopping the ovaries from making estrogen, which can fuel cancer growth. The trial will enroll 75 women an…

This trial tests whether giving two drugs—enfortumab vedotin and pembrolizumab—before surgery can improve outcomes for people with upper tract urothelial cancer (a type of bladder cancer in the kidney or ureter). Participants receive the drugs intravenously, then undergo surgery …

This early-stage trial tests a new combination treatment for children and young adults (ages 3-39) with recurrent malignant brain tumors that can be surgically removed. The treatment uses two genetically modified viruses injected into the tumor site, plus an oral anti-herpes drug…

This early-phase trial tests whether the drug pomalidomide can improve the effects of CAR T-cell therapy in people with B-cell leukemias or lymphomas that have returned or not responded to treatment. The study will enroll 12 adults who have already received CAR T-cell therapy. Re…

This early-phase trial is testing whether adding ruxolitinib to the standard drug enzalutamide can help men with advanced prostate cancer that has spread and stopped responding to hormone therapy. The study will enroll 20 participants to find the safest dose and check for early s…

This study tests whether combining two drugs, pembrolizumab and mogamulizumab, can shrink or control advanced cutaneous T-cell lymphoma (a type of skin cancer) that has returned or not responded to prior therapy. About 23 adults with stage IIB to IVB disease will receive the drug…

This study tests whether taking prednisone, a steroid, before and during radiation therapy can protect the liver in people with liver cancer. About 20 participants will take prednisone for a short time around their radiation sessions. The goal is to see if it reduces liver inflam…

This study tests whether the immunotherapy drug pembrolizumab can shrink or control advanced or recurrent skin cancer near the eye. About 22 adults with this condition will receive the drug. The goal is to see if the cancer responds and if the eye can be saved from surgery.

This study tests whether giving patients with a specific type of throat cancer (p16+ oropharyngeal cancer) a personalized, less intense treatment can keep cancer from coming back while reducing side effects. About 150 adults with early-stage disease will either have surgery follo…

This early-phase study is testing whether the drug ribociclib (Kisqali) can be safely given alongside standard radiation therapy after surgery for women with a high-risk type of breast cancer (HR+/HER2-). About 30 participants will take ribociclib daily for up to 6 weeks while re…

This study tests a drug called pacritinib in 100 people with T-cell lymphoma that has returned or not responded to prior therapy. The main goal is to see how many patients have their tumors shrink or disappear. Participants take the drug and are monitored with scans and skin asse…

This study is for adults with blood disorders who are getting a stem cell transplant from a matched donor. Researchers want to see if giving a special potato starch along with a drug that lowers iron (deferasirox) can help prevent serious complications like graft-versus-host dise…

This study tests whether adding inulin gel, a fiber supplement, to standard immunotherapy drugs (ipilimumab and nivolumab) can help control advanced kidney cancer. About 55 adults with metastatic or locally advanced clear cell or sarcomatoid kidney cancer will take part. Research…

Colon cancer is common but preventable if caught early. While colonoscopy is the best screening tool, many people can't get one due to cost or time. This study collects stool and blood samples from 1,200 adults to find proteins that signal colon polyps or cancer. The goal is to d…

This early-phase trial is testing a radioactive tracer called FAPI-04 to see how well it lights up high-grade neuroendocrine tumors on PET/CT scans. The study will enroll 30 adults with these aggressive tumors to measure where the tracer goes in the body and how much it accumulat…

This study tests different amounts of exercise to see if it can prevent colorectal polyps from returning in people with Familial Adenomatous Polyposis (FAP). About 32 participants will follow a personalized treadmill program at home for 26 weeks. Researchers will check how well p…

This study tests whether a diet low in added sugar, high in fiber, and rich in omega-3s (called LASO-3) can help reduce nerve pain, numbness, and tingling caused by chemotherapy. Fifty cancer survivors who finished chemo at least three months ago will receive virtual nutrition co…

This study tests whether a dietary supplement called resistant potato starch can help prevent joint pain and stiffness caused by aromatase inhibitors, a common breast cancer treatment. About 20 people with stage 0-III breast cancer or at high risk for it will take the supplement …

This study tests a decision aid for breast cancer patients experiencing nerve damage (numbness or tingling) from chemotherapy. The tool provides information about long-term nerve symptoms and helps patients discuss treatment priorities with their doctor. Researchers will enroll 2…

This study tests a 12-week exercise program for Black women who have finished breast cancer treatment. The goal is to see if the program is easy to follow and helps improve well-being. About 75 women will take part, with some starting the program right away and others waiting. Re…

This study tests whether a short, hope-based therapy called solution-focused brief therapy (SFBT) can reduce psychological distress in adolescents and young adults who have had cancer. About 60 survivors aged 15-39 with mild to moderate distress will receive either SFBT or enhanc…

This study tests whether a shorter, more intense radiation course (SBRT, about 2 weeks) is gentler on quality of life than the standard 4-week course for men with prostate cancer who have had their prostate removed. About 136 men will be randomly assigned to one of the two schedu…

This study tests whether a diet rich in whole grains, vegetables, fruit, and fatty fish can reduce persistent fatigue in lymphoma survivors. One hundred participants will receive either the special diet counseling or general health advice over 3 months. The goal is to see if the …

This study is collecting blood and tumor samples from 200 people with metastatic leiomyosarcoma who are starting chemotherapy. Researchers will analyze circulating tumor DNA (ctDNA) and genetic changes to see if they can predict how well the chemotherapy works. Participants also …

This study tests whether web-based tools can help people with hereditary cancer syndromes share risk information with their relatives and encourage them to get genetic testing. Researchers will enroll 625 participants (patients and their relatives) and track how many use the tool…

This study is looking for better ways to detect prostate cancer early in men who have a high genetic risk. Researchers will test urine samples and PSA levels in 200 men aged 35-70 with certain gene mutations. The goal is to see if these tests can predict aggressive prostate cance…

This study tests whether an 8-week, at-home exercise program can improve heart and lung fitness in patients at high risk for heart problems who are about to receive a stem cell transplant. Ten adults will follow a personalized workout plan using a heart rate app. The main goal is…

This study looks at whether giving the chemotherapy drug paclitaxel over a longer period (2-3 hours instead of 1 hour) can help cancer patients with low muscle mass achieve safer drug levels. Researchers will compare drug concentrations in 22 women with breast, stomach, or esopha…

This study looks at whether a blood test for tumor DNA (ctDNA) and detailed scans can help predict how well chemotherapy works in people with a rare soft tissue cancer called leiomyosarcoma. About 40 participants will give blood samples and have scans before, during, and after tr…

This study tests whether an online self-monitoring platform helps patients with lung, colorectal, breast, or prostate cancer track medication safety events and concerns while taking oral anticancer drugs at home. Eighty adult patients currently on active cancer treatment will use…

This study is testing a new fine needle probe that uses light and sound (photoacoustic technology) to measure prostate tissue during a standard biopsy. The probe is inserted like a regular biopsy needle but does not remove tissue. Researchers want to see if it can reliably tell t…

This study looks at whether a special CT scan analysis called parametric response mapping (PRM) can detect early signs of chronic lung disease in people who have had a stem cell transplant. Researchers will follow 375 patients for one year to see if PRM patterns predict lung func…