Can a simple blood test predict chemo success in rare cancer?

NCT ID NCT05653388

Recruiting now Knowledge-focused Sponsor: University of Michigan Rogel Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is collecting blood and tumor samples from 200 people with metastatic leiomyosarcoma who are starting chemotherapy. Researchers will analyze circulating tumor DNA (ctDNA) and genetic changes to see if they can predict how well the chemotherapy works. Participants also fill out a questionnaire about genetics. The goal is to find early biomarkers that could guide treatment decisions.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could identify early markers in the blood that show whether chemotherapy is working, helping doctors tailor treatment sooner.
What could go wrong: This is an observational study, not a treatment trial. It may not find reliable biomarkers, and results may not change current care for years.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

leiomyosarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LEIOMYOSARCOMA

Contacts and locations

Locations

Chris O'Brien Lifehouse
RECRUITING

Camperdown, New South Wales, 2050, Australia
Dana- Farber
RECRUITING

Boston, Massachusetts, 02215, United States
MD Anderson
RECRUITING

Houston, Texas, 77030, United States
Mayo Clinic
RECRUITING

Rochester, Minnesota, 55901, United States
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
Ohio State University
RECRUITING

Columbus, Ohio, 43210, United States
Peter MacCallum Cancer Centre
RECRUITING

Melbourne, Victoria, 3000, Australia
Sarcoma Oncology Research Center
RECRUITING

Santa Monica, California, 90403, United States
University of Miami
RECRUITING

Miami, Florida, 33136, United States
University of Michigan Cancer Center
RECRUITING

Ann Arbor, Michigan, 48109, United States
Vanderbilt University Medical Center
RECRUITING

Nashville, Tennessee, 37232, United States

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