Drug combo shows promise in slowing rare sarcomas
NCT ID NCT03114527
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 trial tests two oral drugs, ribociclib and everolimus, in people with advanced dedifferentiated liposarcoma or leiomyosarcoma who have had at least one prior treatment. The goal is to see if the combination can stop or slow tumor growth. About 48 participants will take the drugs daily in cycles, and their tumors will be scanned regularly to measure response.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Ribociclib and everolimus (two oral cancer drugs)
- What this could lead to
- If successful, this combination could offer a new treatment option to slow tumor growth in people with advanced soft tissue sarcomas who have already tried other therapies.
- What could go wrong
- This is a small, early-phase trial (48 participants) with no placebo group. The drugs may cause side effects like mouth sores, fatigue, or lung inflammation, and may not work for all sarcoma types.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Dana-Farber Cancer Institute
Boston, Massachusetts, 02215, United States
-
Fox Chase Cancer Center
Philadelphia, Pennsylvania, 19111, United States
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