New drug combo shows promise in Tough-to-Treat breast cancer

NCT ID NCT05383196

First seen Nov 13, 2025 · Last updated May 01, 2026 · Updated 22 times

Summary

This study tests whether adding the experimental drug onvansertib to standard chemotherapy (paclitaxel) is safe and effective for people with triple-negative breast cancer that has spread or cannot be removed by surgery. About 50 adults with this aggressive cancer type will receive the combination. The goal is to see if the drugs shrink tumors and to monitor side effects.

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Contacts and locations

Locations

  • Beth Israel Deaconness Medical Center

    Boston, Massachusetts, 02215, United States

  • Dana-Farber Cancer Institute

    Boston, Massachusetts, 02215, United States

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

Conditions

Explore the condition pages connected to this study.