LOCALLY ADVANCED BREAST CANCER

This study is observing how well the drug inavolisib works for people with advanced breast cancer that has a specific genetic mutation and has stopped responding to hormone therapy. Researchers will follow 500 patients in China who are already receiving this treatment as part of …

This large international study is testing whether a new drug called palazestrant works better than the current standard treatment when combined with another cancer drug called ribociclib. The trial will involve about 1,000 adults with advanced breast cancer that hasn't been treat…

This study is testing a new combination of two drugs, called BNT323 and BNT327, for people with advanced breast cancer that has spread or cannot be removed by surgery. The first part of the study aims to find the safest and most effective dose. The second part will compare how we…

This early-stage study aims to find safe and effective doses for a new breast cancer drug, palazestrant, when combined with four different existing cancer drugs. It will enroll about 190 adults with advanced or metastatic ER-positive, HER2-negative breast cancer who have had limi…

This study is testing whether a new drug called HRS-8080 works better than treatments doctors normally choose for women with advanced breast cancer that has stopped responding to hormone therapy. It will involve 240 women whose cancer has spread or is locally advanced. The main g…

This study is testing a new oral drug called FWD1802 for women with a specific type of advanced breast cancer (ER+/HER2-) that has spread or cannot be surgically removed. The first part of the trial aims to find a safe and effective dose. The second part will see how well the dru…

This study is testing whether adding a drug called pyrotinib to the standard one-year treatment (trastuzumab) helps prevent breast cancer from returning in women who still have cancer cells after initial chemotherapy and targeted therapy. It involves about 316 women with a specif…

This trial aims to find the best drug combinations for different types of breast cancer before surgery. It tests new drugs alongside standard chemotherapy in 5,000 women with early-stage or locally advanced breast cancer. The study uses tumor analysis and MRI scans to match treat…

This study is testing whether a 6-month exercise program can help prevent breast cancer from returning in survivors. It will involve over 2,100 women who have completed surgery and other treatments. Participants will either follow a supervised exercise plan or be observed, to see…

This early-stage study is testing the safety and effectiveness of combining two drugs, palbociclib and avelumab, for patients with advanced breast cancer. It focuses on a specific, hard-to-treat type called AR-positive triple-negative breast cancer. The goal is to see if this new…

This study is testing if a special type of mammogram that uses a contrast dye can work as well as a breast MRI to see if chemotherapy successfully shrank a breast tumor before surgery. It involves about 30 people with locally advanced breast cancer who are getting chemotherapy be…

This study is testing if a drug called memantine, combined with a supervised exercise program, can help reduce memory and thinking problems ('chemo brain') during breast cancer chemotherapy. It will involve 90 women with early-stage breast cancer who are already reporting mild co…