New combo therapy targets hard-to-treat breast cancers

NCT ID NCT06827236

Recruiting now Disease control Sponsor: BioNTech SE Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 22, 2026 · Updated 2 times

Summary

This study tests two experimental drugs, BNT323 and BNT327, together in people with advanced breast cancer that has spread or cannot be removed. The goal is to see if the combination can shrink tumors and control the disease. About 380 adults with various types of breast cancer (including HER2-positive, HER2-low, and triple-negative) will take part. The study is in early phases (1 and 2) to find the best dose and check safety.

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Conditions

The condition(s) this trial relates to.

breast cancer breast carcinoma breast neoplasm HER2 positive breast carcinoma Her2-receptor negative breast cancer hormone receptor-positive breast cancer triple-negative breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LOCALLY ADVANCED BREAST CANCER METASTATIC BREAST CANCER UNRESECTABLE BREAST CARCINOMA

Contacts and locations

Locations

Adana City Hospital
RECRUITING

Adana, 01230, Turkey (Türkiye)
Addenbrooke s Hospital
RECRUITING

Cambridge, CB2 0QQ, United Kingdom
Ankara City Hospital
RECRUITING

Ankara, 06800, Turkey (Türkiye)
Azienda Ospedaliera Universitaria Policlinico Sant Orsola Malpighi IRCCS
RECRUITING

Bologna, 40138, Italy
Baylor Scott & White Research Institute -Texas Oncology
RECRUITING

Dallas, Texas, 75246, United States
Beth Israel Comprehensive Cancer Center
RECRUITING

New York, New York, 10011, United States
Beverly Hills Cancer Center
RECRUITING

Beverly Hills, California, 90211, United States
Brigitte Harris Cancer Pavilion BHCP
RECRUITING

Detroit, Michigan, 48202, United States
Cancer Research SA
RECRUITING

Adelaide, 5000, Australia
Centro Integral Oncologico Clara Campal
RECRUITING

Madrid, 28050, Spain
Clinique Victor Hugo - Centre Jean Bernard
RECRUITING

Le Mans, 72000, France
Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
RECRUITING

Ankara, 06200, Turkey (Türkiye)
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
RECRUITING

Roma, 00168, Italy
Fudan University Shanghai Cancer
RECRUITING

Shanghai, 201315, China
Guangxi Medical University Affiliated Tumor Hospital
RECRUITING

Nanning, 530021, China
Hacettepe University Medical Faculty
RECRUITING

Ankara, 06100, Turkey (Türkiye)
Hematology - Oncology Associates of the Treasure Coast
RECRUITING

Port Saint Lucie, Florida, 34952, United States
Hoag Memorial Hospital Presbyterian
RECRUITING

Newport Beach, California, 92663, United States
Hospital Clinic de Barcelona
RECRUITING

Barcelona, 08036, Spain
Hospital HM Nou Delfos
RECRUITING

Barcelona, 08023, Spain
Huizhou First Hospital
RECRUITING

Huizhou, 516003, China
IAU Medical Park Florya Hospital
RECRUITING

Istanbul, 34295, Turkey (Türkiye)
ICO - Site René Gauducheau
RECRUITING

Saint-Herblain, 44800, France
IEO Istituto Europeo di Oncologia
RECRUITING

Milan, 20141, Italy
Icahn School of Medicine at Mount Sinai PRIME
RECRUITING

New York, New York, 10029-6503, United States
Institut Claudius Regaud
RECRUITING

Toulouse, 31059, France
Institute of Oncology Arensia Exploratory Medicine
RECRUITING

Chisinau, 2025, Moldova
Istituto Nazionale Tumori Fondazione G. Pascale
RECRUITING

Naples, 80131, Italy
Jilin Cancer Hospital
RECRUITING

Changchun, 130000, China
Koc University Hospital
RECRUITING

Istanbul, 34010, Turkey (Türkiye)
Konya Necmettin Erbakan University Meram Medical Faculty
RECRUITING

Konya, 42080, Turkey (Türkiye)
LLC Arensia Exploratory Medicine
RECRUITING

Tbilisi, 0112, Georgia
MD Anderson Cancer Centre
RECRUITING

Madrid, 28033, Spain
Medical Park Seyhan Hospital
RECRUITING

Adana, 01140, Turkey (Türkiye)
Memorial Sloan Kettering Cancer Center Basking Ridge
RECRUITING

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Cancer Center Bergen
RECRUITING

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center Monmouth
RECRUITING

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Cancer Center Nassau
RECRUITING

Uniondale, New York, 11553, United States
Memorial Sloan Kettering Cancer Center Westchester
RECRUITING

Harrison, New York, 10604, United States
Memorial Sloan Kettering Commack
RECRUITING

New York, New York, 11725, United States
Memorial Sloan Kettering Hospital
RECRUITING

New York, New York, 10065, United States
Mersin City Education and Research Hospital
RECRUITING

Mersin, 33240, Turkey (Türkiye)
Mount Sinai Medical Center
RECRUITING

New York, New York, 10019, United States
NEXT Barcelona
RECRUITING

Barcelona, 08023, Spain
NEXT Madrid
RECRUITING

Pozuelo de Alarcón, 28223, Spain
Royal Free Hospital
RECRUITING

London, NW3 2QG, United Kingdom
Royal Marsden Hospital
RECRUITING

London, SW36JJ, United Kingdom
Royal Marsden Hospital-Sutton
RECRUITING

Sutton, SM2 5PT, United Kingdom
SCRI Oncology Partners
RECRUITING

Nashville, Tennessee, 37203, United States
START Midwest, LLC
RECRUITING

Grand Rapids, Michigan, 49546, United States
Saint Luke's Hospital of Kansas City
RECRUITING

Kansas City, Missouri, 64111, United States
Sichuan Cancer Hospital
RECRUITING

Chengdu, 610041, China
Sichuan Provincial People's Hospital
RECRUITING

Chengdu, 610072, China
South Texas Accelerated Research Therapeutics (START), LLC
RECRUITING

San Antonio, Texas, 78229, United States
St James's University Hospital
RECRUITING

Leeds, LS9 7TF, United Kingdom
Stony Brook University Hospital
RECRUITING

Stony Brook, New York, 11794, United States
Summit Medical Group
RECRUITING

Florham Park, New Jersey, 07932, United States
Sunnybrook Health Sciences Centre
RECRUITING

Toronto, M4N 3M5, Canada
The Christie Hospital
RECRUITING

Manchester, M20 4BX, United Kingdom
The First Affiliated Hospital of Bengbu Medical College
RECRUITING

Bengbu, 233004, China
The First Affiliated Hospital of Chongqing Medical University
RECRUITING

Chongqing, 400016, China
The Second Affiliated Hospital of Xi an Jiaotong University
RECRUITING

Xi'an, 710004, China
University Cancer & Blood Center, LLC
RECRUITING

Athens, Georgia, 30607, United States
University of Illinois Hospital & Health Sciences System
RECRUITING

Chicago, Illinois, 60612, United States
Velindre Cancer Centre
RECRUITING

Cardiff, CF14 2TL, United Kingdom
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States
Winship Cancer Institute of Emory University
RECRUITING

Atlanta, Georgia, 30322, United States
Yeditepe Universitesi Kosuyolu Hastanesi
RECRUITING

Istanbul, 31755, Turkey (Türkiye)

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